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• W2144971186 startingPage "L361" @default.
• W2144971186 abstract "Exhaled NO (eNO) is a potential noninvasive biomarker of inflammation in asthma. The significant intersubject variability of eNO within clinically similar patients has contributed to its limited clinical application. Arginase and NO synthase (NOS) utilize the same substrate (l-arginine) and contribute to the fibrotic and inflammatory features of asthma, respectively. Interestingly, TGF-β 2 can increase the expression of arginase, stimulates fibrosis, and is overexpressed in asthma. We hypothesized that TGF-β 2 -enhanced arginase activity would decrease gas phase NO release from lung epithelial cells by limiting l-arginine availability for NOS. Our results show that TGF-β 2 (5 ng/ml) significantly enhances total arginase activity up to two- to threefold in both primary small airway epithelial cells (SAECs) and the A549 cell line. Preincubation with TGF-β 2 prior to cytokine (IL-1β, TNF-α, and IFN-γ, 10 ng/ml each) stimulation decreases gas phase NO release to baseline levels (from 1.66 ± 0.52 to 0.30 ± 0.12 pl·s −1 ·cm −2 and from 0.27 ± 0.03 pl·s −1 ·cm −2 to near zero in SAEC and A549 cells, respectively). Addition of arginase inhibitor ( N ω -hydroxy-nor-l-arginine) or small interfering RNA only partly reverses the reduction. In contrast, Rho-kinase (ROCK) pathway inhibitor (Y-27632) completely recovers the cytokine-induced NO flux in the present of TGF-β 2 . Inducible NO synthase (iNOS) mRNA and protein levels change in a similar trend as NO release from the cells. We conclude that TGF-β 2 impacts cytokine-induced NO production in airway epithelial cells by reducing iNOS mRNA and protein levels through a ROCK-dependent pathway." @default.
• W2144971186 created "2016-06-24" @default.
• W2144971186 creator A5033666255 @default.
• W2144971186 creator A5040731013 @default.
• W2144971186 date "2011-09-01" @default.
• W2144971186 modified "2023-10-18" @default.
• W2144971186 title "TGF-β₂ reduces nitric oxide synthase mRNA through a ROCK-dependent pathway in airway epithelial cells" @default.
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• W2144971186 doi "https://doi.org/10.1152/ajplung.00464.2010" @default.
• W2144971186 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3174748" @default.
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• W2144971186 hasPublicationYear "2011" @default.
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