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- W2144975326 abstract "Summary Clostridia belong to those bacteria which are considered as obligate anaerobe, e.g. oxygen is harmful or lethal to these bacteria. Nevertheless, it is known that they can survive limited exposure to air, and often eliminate oxygen or reactive derivatives via NAD(P)H‐dependent reduction. This system does apparently contribute to survival after oxidative stress, but is insufficient to establish long‐term tolerance of aerobic conditions. Here we show that manipulation of the regulatory mechanism of this defence mechanism can trigger aerotolerance in the obligate anaerobe Clostridium acetobutylicum . Deletion of a peroxide repressor (PerR)‐homologous protein resulted in prolonged aerotolerance, limited growth under aerobic conditions and rapid consumption of oxygen from an aerobic environment. The mutant strain also revealed higher resistance to H 2 O 2 and activities of NADH‐dependent scavenging of H 2 O 2 and organic peroxides in cell‐free extracts increased by at least one order of magnitude. Several genes encoding the putative enzymes were upregulated and identified as members of the clostridial PerR regulon, including the heat shock protein Hsp21, a reverse rubrerythrin which was massively produced and became the most abundant protein in the absence of PerR. This multifunctional protein is proposed to play the crucial role in the oxidative stress defence." @default.
- W2144975326 created "2016-06-24" @default.
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- W2144975326 date "2008-03-25" @default.
- W2144975326 modified "2023-10-10" @default.
- W2144975326 title "PerR acts as a switch for oxygen tolerance in the strict anaerobe Clostridium acetobutylicum" @default.
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- W2144975326 doi "https://doi.org/10.1111/j.1365-2958.2008.06192.x" @default.
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