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- W2144992020 abstract "There is an ongoing discussion whether ALS is primarily a disease of upper motor neurons or lower motor neurons. We undertook a review to assess how new insights have contributed to solve this controversy. For this purpose we selected relevant publications from 1995 onwards focussing on (1) primary targets and disease progression in ALS and variants of ALS, (2) brain imaging markers for upper motor neuron lesion, and (3) evidence for ALS being a multisystem disorder. Clinically, upper motor and lower motor neuron symptoms can occur in any order over time. Brain imaging markers show upper motor neuron involvement in early disease. Overlap syndromes of ALS and dementia, and involvement of autonomic and sensory nerves occur frequently. PET/SPECT scans, functional MRI and voxel based morphometry studies clearly show abnormalities in extra-motor areas of the brain. Pathologically, the 43 kDa TAR DNA-binding protein (TDP-43) provides a clue to these overlapping disorders. In conclusion, evidence accumulates that ALS is a multisystem disorder rather than a pure lower and/or upper motor neuron disorder." @default.
- W2144992020 created "2016-06-24" @default.
- W2144992020 creator A5019621549 @default.
- W2144992020 creator A5032625076 @default.
- W2144992020 creator A5045032467 @default.
- W2144992020 creator A5072736652 @default.
- W2144992020 date "2009-01-01" @default.
- W2144992020 modified "2023-09-23" @default.
- W2144992020 title "Upper motor neuron and extra-motor neuron involvement in amyotrophic lateral sclerosis: A clinical and brain imaging review" @default.
- W2144992020 cites W1515582500 @default.
- W2144992020 cites W1576684777 @default.
- W2144992020 cites W1619082318 @default.
- W2144992020 cites W1792205889 @default.
- W2144992020 cites W1964177214 @default.
- W2144992020 cites W1970428457 @default.
- W2144992020 cites W1972539656 @default.
- W2144992020 cites W1976832883 @default.
- W2144992020 cites W1977977177 @default.
- W2144992020 cites W1978456065 @default.
- W2144992020 cites W1985788233 @default.
- W2144992020 cites W1987173022 @default.
- W2144992020 cites W1989240097 @default.
- W2144992020 cites W1991192713 @default.
- W2144992020 cites W1993060243 @default.
- W2144992020 cites W1993184479 @default.
- W2144992020 cites W1999387079 @default.
- W2144992020 cites W2003127673 @default.
- W2144992020 cites W2003618511 @default.
- W2144992020 cites W2009024978 @default.
- W2144992020 cites W2017372277 @default.
- W2144992020 cites W2018110972 @default.
- W2144992020 cites W2022256832 @default.
- W2144992020 cites W2024647833 @default.
- W2144992020 cites W2024716339 @default.
- W2144992020 cites W2026282890 @default.
- W2144992020 cites W2028190721 @default.
- W2144992020 cites W2030403819 @default.
- W2144992020 cites W2031105254 @default.
- W2144992020 cites W2031964319 @default.
- W2144992020 cites W2033158384 @default.
- W2144992020 cites W2034031504 @default.
- W2144992020 cites W2042450904 @default.
- W2144992020 cites W2042615359 @default.
- W2144992020 cites W2042930414 @default.
- W2144992020 cites W2047061352 @default.
- W2144992020 cites W2050860956 @default.
- W2144992020 cites W2053362200 @default.
- W2144992020 cites W2053745540 @default.
- W2144992020 cites W2053848550 @default.
- W2144992020 cites W2056308966 @default.
- W2144992020 cites W2063442285 @default.
- W2144992020 cites W2065140753 @default.
- W2144992020 cites W2065488153 @default.
- W2144992020 cites W2068147651 @default.
- W2144992020 cites W2068208779 @default.
- W2144992020 cites W2074658666 @default.
- W2144992020 cites W2086607859 @default.
- W2144992020 cites W2091391462 @default.
- W2144992020 cites W2092283398 @default.
- W2144992020 cites W2092646825 @default.
- W2144992020 cites W2093276554 @default.
- W2144992020 cites W2094221606 @default.
- W2144992020 cites W2094469765 @default.
- W2144992020 cites W2097494128 @default.
- W2144992020 cites W2100641977 @default.
- W2144992020 cites W2100765938 @default.
- W2144992020 cites W2101146082 @default.
- W2144992020 cites W2101748834 @default.
- W2144992020 cites W2109432431 @default.
- W2144992020 cites W2115672510 @default.
- W2144992020 cites W2116638854 @default.
- W2144992020 cites W2125299413 @default.
- W2144992020 cites W2127151031 @default.
- W2144992020 cites W2127621677 @default.
- W2144992020 cites W2127861463 @default.
- W2144992020 cites W2130202191 @default.
- W2144992020 cites W2134051267 @default.
- W2144992020 cites W2134140648 @default.
- W2144992020 cites W2134551134 @default.
- W2144992020 cites W2137893253 @default.
- W2144992020 cites W2138167729 @default.
- W2144992020 cites W2139419933 @default.
- W2144992020 cites W2140668076 @default.
- W2144992020 cites W2145132952 @default.
- W2144992020 cites W2146300304 @default.
- W2144992020 cites W2148407847 @default.
- W2144992020 cites W2152868092 @default.
- W2144992020 cites W2152930788 @default.
- W2144992020 cites W2154446698 @default.
- W2144992020 cites W2155895917 @default.
- W2144992020 cites W2161938104 @default.
- W2144992020 cites W2164647869 @default.
- W2144992020 cites W2166130753 @default.
- W2144992020 cites W2169288901 @default.
- W2144992020 cites W2170463782 @default.
- W2144992020 doi "https://doi.org/10.1016/j.nmd.2008.10.002" @default.
- W2144992020 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19070491" @default.
- W2144992020 hasPublicationYear "2009" @default.