FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2144993485> ?p ?o ?g. }

• W2144993485 endingPage "2529" @default.
• W2144993485 startingPage "2524" @default.
• W2144993485 abstract "The coordinated activation of extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase (p38MAPK) is critical for the induction of vascular and visceral smooth muscle cell (SMC) dedifferentiation. We previously reported that on the forced activation of both MAPKs, visceral SMCs secrete a non-heparin-binding protein factor(s) that is involved in the dedifferentiation of neighboring SMCs. In this study, we sought to identify the dedifferentiation factor(s) derived from vascular SMCs (VSMCs).We fractionated the VSMC dedifferentiation factor(s) in the conditioned medium obtained from differentiated VSMCs in which both ERK and p38MAPK were forcedly activated and identified epiregulin as a major autocrine/paracrine factor for VSMC dedifferentiation. The epiregulin-induced VSMC dedifferentiation was mediated through the coordinated activation of ERK and p38MAPK. Unsaturated lysophosphatidic acid and platelet-derived growth factor-BB, which are potent VSMC dedifferentiation factors, rapidly upregulated epiregulin mRNA expression in an ERK- and p38MAPK-dependent manner. Reverse transcriptase-polymerase chain reaction and/or immunohistological analyses revealed the restricted expression of epiregulin in human atherosclerotic and balloon-injured rat arteries, in which the phenotypic modulation of medial VSMCs occurred in vivo.Epiregulin is released from VSMCs primed by atherogenic factors and acts as a major autocrine/paracrine factor for VSMC dedifferentiation. It may be involved in the progression of vascular remodeling such as atherosclerosis." @default.
• W2144993485 created "2016-06-24" @default.
• W2144993485 creator A5002605322 @default.
• W2144993485 creator A5003506675 @default.
• W2144993485 creator A5009691281 @default.
• W2144993485 creator A5015130954 @default.
• W2144993485 creator A5026631659 @default.
• W2144993485 creator A5036244962 @default.
• W2144993485 creator A5037320870 @default.
• W2144993485 creator A5059316181 @default.
• W2144993485 creator A5063649274 @default.
• W2144993485 creator A5071406482 @default.
• W2144993485 creator A5086338873 @default.
• W2144993485 date "2003-11-18" @default.
• W2144993485 modified "2023-10-10" @default.
• W2144993485 title "Epiregulin as a Major Autocrine/Paracrine Factor Released From ERK- and p38MAPK-Activated Vascular Smooth Muscle Cells" @default.
• W2144993485 cites W1534692597 @default.
• W2144993485 cites W1607351680 @default.
• W2144993485 cites W1981930770 @default.
• W2144993485 cites W2005312651 @default.
• W2144993485 cites W2012527427 @default.
• W2144993485 cites W2049099038 @default.
• W2144993485 cites W2119465831 @default.
• W2144993485 cites W2132475459 @default.
• W2144993485 cites W2134665522 @default.
• W2144993485 cites W2137570167 @default.
• W2144993485 cites W2160761045 @default.
• W2144993485 cites W2340830559 @default.
• W2144993485 doi "https://doi.org/10.1161/01.cir.0000096482.02567.8c" @default.
• W2144993485 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14581411" @default.
• W2144993485 hasPublicationYear "2003" @default.
• W2144993485 type Work @default.
• W2144993485 sameAs 2144993485 @default.
• W2144993485 citedByCount "66" @default.
• W2144993485 countsByYear W21449934852012 @default.
• W2144993485 countsByYear W21449934852013 @default.
• W2144993485 countsByYear W21449934852014 @default.
• W2144993485 countsByYear W21449934852015 @default.
• W2144993485 countsByYear W21449934852016 @default.
• W2144993485 countsByYear W21449934852017 @default.
• W2144993485 countsByYear W21449934852018 @default.
• W2144993485 countsByYear W21449934852019 @default.
• W2144993485 countsByYear W21449934852020 @default.
• W2144993485 countsByYear W21449934852021 @default.
• W2144993485 countsByYear W21449934852022 @default.
• W2144993485 countsByYear W21449934852023 @default.
• W2144993485 crossrefType "journal-article" @default.
• W2144993485 hasAuthorship W2144993485A5002605322 @default.
• W2144993485 hasAuthorship W2144993485A5003506675 @default.
• W2144993485 hasAuthorship W2144993485A5009691281 @default.
• W2144993485 hasAuthorship W2144993485A5015130954 @default.
• W2144993485 hasAuthorship W2144993485A5026631659 @default.
• W2144993485 hasAuthorship W2144993485A5036244962 @default.
• W2144993485 hasAuthorship W2144993485A5037320870 @default.
• W2144993485 hasAuthorship W2144993485A5059316181 @default.
• W2144993485 hasAuthorship W2144993485A5063649274 @default.
• W2144993485 hasAuthorship W2144993485A5071406482 @default.
• W2144993485 hasAuthorship W2144993485A5086338873 @default.
• W2144993485 hasBestOaLocation W21449934851 @default.
• W2144993485 hasConcept C126322002 @default.
• W2144993485 hasConcept C128240485 @default.
• W2144993485 hasConcept C134018914 @default.
• W2144993485 hasConcept C170493617 @default.
• W2144993485 hasConcept C2775960820 @default.
• W2144993485 hasConcept C2777968868 @default.
• W2144993485 hasConcept C2779395532 @default.
• W2144993485 hasConcept C2780806702 @default.
• W2144993485 hasConcept C2992686903 @default.
• W2144993485 hasConcept C57074206 @default.
• W2144993485 hasConcept C62478195 @default.
• W2144993485 hasConcept C71924100 @default.
• W2144993485 hasConcept C7876069 @default.
• W2144993485 hasConcept C86803240 @default.
• W2144993485 hasConcept C95444343 @default.
• W2144993485 hasConceptScore W2144993485C126322002 @default.
• W2144993485 hasConceptScore W2144993485C128240485 @default.
• W2144993485 hasConceptScore W2144993485C134018914 @default.
• W2144993485 hasConceptScore W2144993485C170493617 @default.
• W2144993485 hasConceptScore W2144993485C2775960820 @default.
• W2144993485 hasConceptScore W2144993485C2777968868 @default.
• W2144993485 hasConceptScore W2144993485C2779395532 @default.
• W2144993485 hasConceptScore W2144993485C2780806702 @default.
• W2144993485 hasConceptScore W2144993485C2992686903 @default.
• W2144993485 hasConceptScore W2144993485C57074206 @default.
• W2144993485 hasConceptScore W2144993485C62478195 @default.
• W2144993485 hasConceptScore W2144993485C71924100 @default.
• W2144993485 hasConceptScore W2144993485C7876069 @default.
• W2144993485 hasConceptScore W2144993485C86803240 @default.
• W2144993485 hasConceptScore W2144993485C95444343 @default.
• W2144993485 hasIssue "20" @default.
• W2144993485 hasLocation W21449934851 @default.
• W2144993485 hasLocation W21449934852 @default.
• W2144993485 hasOpenAccess W2144993485 @default.
• W2144993485 hasPrimaryLocation W21449934851 @default.
• W2144993485 hasRelatedWork W1963652002 @default.
• W2144993485 hasRelatedWork W1969354036 @default.
• W2144993485 hasRelatedWork W1996832816 @default.
• W2144993485 hasRelatedWork W2015867957 @default.

• next