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- W2144996971 abstract "Summary Many studies on the role of merozoite surface protein 3 (MSP3) in immunity against malaria have focused on a conserved section of MSP3. New evidence suggests that polymorphic sequences within MSP3 are under immune selection. We report a detailed analysis of naturally‐acquired antibodies to allele‐specific and conserved parts of MSP3 in a Kenyan cohort. Indirect and competition ELISA to heterologous recombinant MSP3 proteins were used for antibody assays, and parasites were genotyped for msp3 alleles. Antibody reactivity to allele‐specific and conserved epitopes of MSP3 was heterogenous between individuals. Overall, the prevalence of allele‐specific antibody reactivity was significantly higher (3D7‐specific 54%, K1‐specific 41%) than that to a recombinant protein representing a conserved portion of C‐terminal MSP3 (24%, P < 0·01). The most abundant IgG subclass was IgG3, followed by IgG1. Allele‐specific reactivity to the K1‐type of MSP3 was associated with a lower risk of clinical malaria episodes during a 6‐month follow‐up in individuals who were parasitized at the start of the malaria transmission season (Relative risk 0·41 with 95% confidence interval 0·20–0·81, P = 0·011). The potential importance of allele‐specific immunity to MSP3 should be considered in addition to immunity to conserved epitopes, in the development of an MSP3 malaria vaccine." @default.
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- W2144996971 date "2007-07-23" @default.
- W2144996971 modified "2023-10-10" @default.
- W2144996971 title "Naturally acquired antibodies to polymorphic and conserved epitopes of Plasmodium falciparum merozoite surface protein 3" @default.
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- W2144996971 doi "https://doi.org/10.1111/j.1365-3024.2007.00951.x" @default.
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