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• W2145049655 abstract "<h3>Objective</h3> To evaluate whether time to pregnancy (TTP) is associated with neurological condition of 2-year-old children born to subfertile parents. <h3>Design</h3> Data collected in a prospective, assessor-blinded follow-up study were used for cross-sectional analyses. <h3>Patients</h3> Participants were the singletons of the Groningen assisted reproductive technique cohort study: all children were born to subfertile couples (n=209). The active waiting TTP of the couples obtained from fertility charts was recorded in years and months, and was converted to decimal years. <h3>Main outcome measure</h3> The presence of minor neurological dysfunction (MND), assessed with the Hempel examination. <h3>Results</h3> MND was present in 16 (7.7%) children. TTP of children with MND (median 4.1, range 1.6–13.2) was significantly longer than that of children without MND (median 2.8, range 0.1–13.3; Mann-Whitney U test p=0.014). Logistic regression analysis on the contribution of TTP to MND resulted in a crude OR of 1.27 (95% CI 1.06 to 1.54). After correction for gestational age, parental age and parental level of education, the association remained statistically significant: OR=1.30 (95% CI 1.05 to 1.61). <h3>Conclusions</h3> Increased TTP was associated with suboptimal neurological development in 2-year-old children. This suggests that subfertility and its determinants are involved in the genesis of neurodevelopmental problems." @default.
• W2145049655 created "2016-06-24" @default.
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• W2145049655 date "2013-03-25" @default.
• W2145049655 modified "2023-10-18" @default.
• W2145049655 title "Increased time to pregnancy is associated with suboptimal neurological condition of 2-year-olds" @default.
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• W2145049655 doi "https://doi.org/10.1136/archdischild-2012-303366" @default.
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