Matches in SemOpenAlex for { <https://semopenalex.org/work/W2145072010> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2145072010 endingPage "235" @default.
- W2145072010 startingPage "230" @default.
- W2145072010 abstract "Bromobenzene으로 간독성을 유발한 흰쥐에 생열귀나무 뿌리를 투여하여 bromobenzene 대사계에 미치는 효소활성을 관찰하였다. Bromobenzene은 bromobenzene 2,3-oxide와 bromobenzene-3, 4-oxide로 전환되며, 3,4-oxide는 독성물질로서 epoxide hydrolase에 의해 무독성 bromobenzene-3,4-dihyrodiol로 대사 또는 glutathione S-transferase에 의하여 배설되기도 한다. 중국 민간에서 강장제로 사용하는 생열귀나무는 한방에서 소화불량, 위통 등의 치료에 사용되는 약용식물이다. 생열귀나무의 뿌리 추출물은 흰쥐의 간 epoxide 생성계에 관여하는 aminopyrine N-demethylase, aniline hydroxylase 활성과 epoxide를 대사시키는 glutathione S-transferase 활성에는 변화를 주지 않았다. 그러나 생열귀추출물 500 mg/kg 경구투여군은 eporide를 무독화시키는 epoxide hydrolase 활성에서 bromobenzene 투여로 효소활성이 저하된 대조군보다 33% 활성을 회복시켰다. 따라서 생열귀나무 뿌리는 간독성물질인 bromobenzene 대사에 관여하는 epoxide hydrolase 활성 증가로 인해 간보호작용이 일어나는 것으로 판단된다. To investigate hepatoprotective activities of the root extract of Rosa davurica, the activities of hepatic enzymes, aminopyrine N-demethylase, aniline hydroxylase, glutathione S-transferase and epoxide hydrolase in rats intoxicated with bromobenzene were studied. Pretreatment with the methanol extract from the roots of Rosa davurica did not show any significant effects on the increases of the activities of aminopyrine N-demethylase and aniline hydroxylase, enzymes forming toxic epoxide by bromobenzene. There was no change in glutathione S-transferase activity by Rosa davurica. However, the activity of epoxide hydrolase, and epoxide-removing enzyme, was increased 33% by the administration of 500 mg/kg of the methanol extract. From the results, the protection of Rosa davurica against bromobenzene-induced hepatotoxicity is thought to be via enhancing the activity of epoxide hydrolase, an enzyme removing toxic epoxide rather than through epoxide-producing system." @default.
- W2145072010 created "2016-06-24" @default.
- W2145072010 creator A5009658289 @default.
- W2145072010 creator A5017005854 @default.
- W2145072010 creator A5020934720 @default.
- W2145072010 creator A5037625746 @default.
- W2145072010 creator A5037659157 @default.
- W2145072010 creator A5044836337 @default.
- W2145072010 date "2003-04-01" @default.
- W2145072010 modified "2023-09-26" @default.
- W2145072010 title "Hepatoprotective Activities of Rosa davurica Root Extract in Rats Intoxicated with Bromobenzene" @default.
- W2145072010 cites W1581414347 @default.
- W2145072010 cites W1775749144 @default.
- W2145072010 cites W1976435755 @default.
- W2145072010 cites W2024851280 @default.
- W2145072010 cites W2043580861 @default.
- W2145072010 cites W2064143702 @default.
- W2145072010 cites W2068404621 @default.
- W2145072010 cites W2073092594 @default.
- W2145072010 cites W2266397338 @default.
- W2145072010 cites W2317154051 @default.
- W2145072010 doi "https://doi.org/10.5352/jls.2003.13.2.230" @default.
- W2145072010 hasPublicationYear "2003" @default.
- W2145072010 type Work @default.
- W2145072010 sameAs 2145072010 @default.
- W2145072010 citedByCount "2" @default.
- W2145072010 countsByYear W21450720102015 @default.
- W2145072010 crossrefType "journal-article" @default.
- W2145072010 hasAuthorship W2145072010A5009658289 @default.
- W2145072010 hasAuthorship W2145072010A5017005854 @default.
- W2145072010 hasAuthorship W2145072010A5020934720 @default.
- W2145072010 hasAuthorship W2145072010A5037625746 @default.
- W2145072010 hasAuthorship W2145072010A5037659157 @default.
- W2145072010 hasAuthorship W2145072010A5044836337 @default.
- W2145072010 hasBestOaLocation W21450720101 @default.
- W2145072010 hasConcept C101819947 @default.
- W2145072010 hasConcept C161790260 @default.
- W2145072010 hasConcept C181199279 @default.
- W2145072010 hasConcept C185592680 @default.
- W2145072010 hasConcept C2776920199 @default.
- W2145072010 hasConcept C2776946247 @default.
- W2145072010 hasConcept C538909803 @default.
- W2145072010 hasConcept C55493867 @default.
- W2145072010 hasConcept C87644729 @default.
- W2145072010 hasConceptScore W2145072010C101819947 @default.
- W2145072010 hasConceptScore W2145072010C161790260 @default.
- W2145072010 hasConceptScore W2145072010C181199279 @default.
- W2145072010 hasConceptScore W2145072010C185592680 @default.
- W2145072010 hasConceptScore W2145072010C2776920199 @default.
- W2145072010 hasConceptScore W2145072010C2776946247 @default.
- W2145072010 hasConceptScore W2145072010C538909803 @default.
- W2145072010 hasConceptScore W2145072010C55493867 @default.
- W2145072010 hasConceptScore W2145072010C87644729 @default.
- W2145072010 hasIssue "2" @default.
- W2145072010 hasLocation W21450720101 @default.
- W2145072010 hasOpenAccess W2145072010 @default.
- W2145072010 hasPrimaryLocation W21450720101 @default.
- W2145072010 hasRelatedWork W1848642262 @default.
- W2145072010 hasRelatedWork W2068382706 @default.
- W2145072010 hasRelatedWork W2068858913 @default.
- W2145072010 hasRelatedWork W2083367091 @default.
- W2145072010 hasRelatedWork W2145072010 @default.
- W2145072010 hasRelatedWork W2219348253 @default.
- W2145072010 hasRelatedWork W2261739482 @default.
- W2145072010 hasRelatedWork W2439563409 @default.
- W2145072010 hasRelatedWork W329767867 @default.
- W2145072010 hasRelatedWork W1893381948 @default.
- W2145072010 hasVolume "13" @default.
- W2145072010 isParatext "false" @default.
- W2145072010 isRetracted "false" @default.
- W2145072010 magId "2145072010" @default.
- W2145072010 workType "article" @default.