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• W2145074844 endingPage "765" @default.
• W2145074844 startingPage "765" @default.
• W2145074844 abstract "Many studies have shown that in vitro culture can negatively impact preimplantation development. This necessitates some selection criteria for identifying the best-suited embryos for transfer. That said, embryo selection after in vitro culture remains a subjective process in most mammalian species, including cows, mice and humans. General consensus in the field is that embryos that develop in a timely manner have the highest developmental competence and viability after transfer. Herein lies the key question: what is a timely manner? With emerging data in bovine and mouse supporting increased developmental competency in embryos with moderate rates of development, it is time to question whether the fastest developing embryos are the best embryos for transfer in the human clinic. This is especially relevant to epigenetic gene regulation, including genomic imprinting, where faster developing embryos exhibit loss of imprinted methylation, as well as to sex selection bias, where faster developmental rates of male embryos may lead to biased embryo transfer and, in turn, biased sex ratios. In this review, we explore evidence surrounding the question of developmental timing as it relates to bovine embryo quality, mouse embryo quality and genomic imprint maintenance, and embryo sex." @default.
• W2145074844 created "2016-06-24" @default.
• W2145074844 creator A5048311187 @default.
• W2145074844 creator A5048685893 @default.
• W2145074844 creator A5082938916 @default.
• W2145074844 creator A5083222784 @default.
• W2145074844 date "2015-01-01" @default.
• W2145074844 modified "2023-10-03" @default.
• W2145074844 title "Why we should not select the faster embryo: lessons from mice and cattle" @default.
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