Matches in SemOpenAlex for { <https://semopenalex.org/work/W2145089422> ?p ?o ?g. }
- W2145089422 abstract "Diabetes mellitus is a complex disorder of energy metabolism of human body. In last WHO/ADA classification, main forms of this disease are Type 1 (T1DM) and Type 2 (T2DM) diabetes mellitus. According to same classification, pathogenesis of T2DM is considered to include a progressive insulin secretory defect on background of insulin resistance. Recently, controversies surround concept of peripheral insulin resistance emerging in 70's as an attempt to explain differences from T1DM phenotype whose autoimmune nature was as that time revealed. The insulin resistance hypothesis was based on supposition that high plasma insulin levels are result of a primary molecular defect against which normal beta cells will react with an increased insulin secretion. This hypothesis has been used to explain both pathogenesis of T2DM and metabolic syndrome, named also for a short period of time the insulin resistance syndrome. We will try to argue that what it is attributed to peripheral insulin resistance belongs in fact to obesity. Special emphasis is put on role of adipocytes, including secretion of different adipokines with secondary lipotoxicity, oxidative stress and pro-inflammatory reaction, explaining complex relationship between obesity and diabetes." @default.
- W2145089422 created "2016-06-24" @default.
- W2145089422 creator A5027089813 @default.
- W2145089422 date "2011-01-01" @default.
- W2145089422 modified "2023-10-15" @default.
- W2145089422 title "Insulin Resistance - What is Myth and What is Reality?" @default.
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