FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2145103418> ?p ?o ?g. }

• W2145103418 endingPage "1683" @default.
• W2145103418 startingPage "1674" @default.
• W2145103418 abstract "Dendritic cells (DCs) can initiate immune responses or confer immune tolerance depending on functional status. LPS-induced DC maturation is defined by enhanced surface expression of CD80 and CD86. MicroRNAs are critical for the regulation of DC function and immunity, and the microRNA let-7i was upregulated during LPS-induced DC maturation. Downregulation of let-7i significantly impeded DC maturation as evidenced by reduced CD80 and CD86 expression. DCs stimulated by LPS promoted T cell proliferation in coculture, whereas LPS-stimulated DCs with downregulated let-7i were not effective at stimulating T cell proliferation but promoted expansion of the regulatory T cell (Treg) population. There were two subpopulations of LPS-stimulated DCs with downregulated let-7i, CD86(-) and CD86(+), and it was the CD86(-) DCs that were more effective in inducing T cell hyporesponsiveness and enhancing Treg numbers, indicating that this DC population had tolerogenic properties. Furthermore, Tregs with upregulated IL-10 underscored the tolerogenic effect of CD86(-) DCs. Suppressor of cytokine signaling 1 (SOCS1), a crucial mediator of DC maturation, was confirmed as a let-7i target gene by luciferase construct assay. Suppression or overexpression of let-7i caused reciprocal alterations in SOCS1 protein expression, but had no significant effects on SOCS1 mRNA levels, indicating that let-7i regulated SOCS1 expression by translational suppression. The modulation of SOCS1 protein by let-7i was mainly restricted to CD86(-) DCs. Our study demonstrates that let-7i regulation of SOCS1 is critical for LPS-induced DC maturation and immune function. Dynamic regulation of let-7i may fine-tune immune responses by inducing Ag-specific immune tolerance." @default.
• W2145103418 created "2016-06-24" @default.
• W2145103418 creator A5006601393 @default.
• W2145103418 creator A5008074653 @default.
• W2145103418 creator A5016796082 @default.
• W2145103418 creator A5018728349 @default.
• W2145103418 creator A5026984704 @default.
• W2145103418 creator A5032733489 @default.
• W2145103418 creator A5080723807 @default.
• W2145103418 creator A5083532124 @default.
• W2145103418 creator A5085025467 @default.
• W2145103418 date "2011-07-08" @default.
• W2145103418 modified "2023-10-11" @default.
• W2145103418 title "Inhibition of MicroRNA <i>let-7i</i> Depresses Maturation and Functional State of Dendritic Cells in Response to Lipopolysaccharide Stimulation via Targeting Suppressor of Cytokine Signaling 1" @default.
• W2145103418 cites W109149726 @default.
• W2145103418 cites W144423133 @default.
• W2145103418 cites W1504695357 @default.
• W2145103418 cites W1562744397 @default.
• W2145103418 cites W1920303762 @default.
• W2145103418 cites W1975579793 @default.
• W2145103418 cites W1978337436 @default.
• W2145103418 cites W1991443279 @default.
• W2145103418 cites W1993247953 @default.
• W2145103418 cites W2011438792 @default.
• W2145103418 cites W2011786245 @default.
• W2145103418 cites W2013892065 @default.
• W2145103418 cites W2015861720 @default.
• W2145103418 cites W2016231119 @default.
• W2145103418 cites W2023495875 @default.
• W2145103418 cites W2024716296 @default.
• W2145103418 cites W2034763496 @default.
• W2145103418 cites W2036812884 @default.
• W2145103418 cites W2071760372 @default.
• W2145103418 cites W2085441977 @default.
• W2145103418 cites W2091798323 @default.
• W2145103418 cites W2092806584 @default.
• W2145103418 cites W2092921155 @default.
• W2145103418 cites W2093442991 @default.
• W2145103418 cites W2094426046 @default.
• W2145103418 cites W2111220263 @default.
• W2145103418 cites W2116603615 @default.
• W2145103418 cites W2119013116 @default.
• W2145103418 cites W2119715606 @default.
• W2145103418 cites W2123580197 @default.
• W2145103418 cites W2124717009 @default.
• W2145103418 cites W2125929767 @default.
• W2145103418 cites W2127629254 @default.
• W2145103418 cites W2131118100 @default.
• W2145103418 cites W2144038313 @default.
• W2145103418 cites W2151394849 @default.
• W2145103418 cites W2167875873 @default.
• W2145103418 cites W2170647698 @default.
• W2145103418 cites W3187389363 @default.
• W2145103418 doi "https://doi.org/10.4049/jimmunol.1001937" @default.
• W2145103418 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21742974" @default.
• W2145103418 hasPublicationYear "2011" @default.
• W2145103418 type Work @default.
• W2145103418 sameAs 2145103418 @default.
• W2145103418 citedByCount "69" @default.
• W2145103418 countsByYear W21451034182012 @default.
• W2145103418 countsByYear W21451034182013 @default.
• W2145103418 countsByYear W21451034182014 @default.
• W2145103418 countsByYear W21451034182015 @default.
• W2145103418 countsByYear W21451034182016 @default.
• W2145103418 countsByYear W21451034182017 @default.
• W2145103418 countsByYear W21451034182018 @default.
• W2145103418 countsByYear W21451034182019 @default.
• W2145103418 countsByYear W21451034182020 @default.
• W2145103418 countsByYear W21451034182021 @default.
• W2145103418 countsByYear W21451034182022 @default.
• W2145103418 crossrefType "journal-article" @default.
• W2145103418 hasAuthorship W2145103418A5006601393 @default.
• W2145103418 hasAuthorship W2145103418A5008074653 @default.
• W2145103418 hasAuthorship W2145103418A5016796082 @default.
• W2145103418 hasAuthorship W2145103418A5018728349 @default.
• W2145103418 hasAuthorship W2145103418A5026984704 @default.
• W2145103418 hasAuthorship W2145103418A5032733489 @default.
• W2145103418 hasAuthorship W2145103418A5080723807 @default.
• W2145103418 hasAuthorship W2145103418A5083532124 @default.
• W2145103418 hasAuthorship W2145103418A5085025467 @default.
• W2145103418 hasBestOaLocation W21451034181 @default.
• W2145103418 hasConcept C104317684 @default.
• W2145103418 hasConcept C126042315 @default.
• W2145103418 hasConcept C127561419 @default.
• W2145103418 hasConcept C14077384 @default.
• W2145103418 hasConcept C154317977 @default.
• W2145103418 hasConcept C179185449 @default.
• W2145103418 hasConcept C185592680 @default.
• W2145103418 hasConcept C187316574 @default.
• W2145103418 hasConcept C202751555 @default.
• W2145103418 hasConcept C203014093 @default.
• W2145103418 hasConcept C2776090121 @default.
• W2145103418 hasConcept C2778170410 @default.
• W2145103418 hasConcept C2778297628 @default.
• W2145103418 hasConcept C2778690821 @default.
• W2145103418 hasConcept C2778923194 @default.
• W2145103418 hasConcept C2781101188 @default.
• W2145103418 hasConcept C2908647359 @default.

• next