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• W2145133103 startingPage "204173141350335" @default.
• W2145133103 abstract "Drug molecules with lack of specificity and solubility lead patients to take high doses of the drug to achieve sufficient therapeutic effects. This is a leading cause of adverse drug reactions, particularly for drugs with narrow therapeutic window or cytotoxic chemotherapeutics. To address these problems, there are various functional biocompatible drug carriers available in the market, which can deliver therapeutic agents to the target site in a controlled manner. Among the carriers developed thus far, mesoporous materials emerged as a promising candidate that can deliver a variety of drug molecules in a controllable and sustainable manner. In particular, mesoporous silica nanoparticles are widely used as a delivery reagent because silica possesses favourable chemical properties, thermal stability and biocompatibility. Currently, sol-gel-derived mesoporous silica nanoparticles in soft conditions are of main interest due to simplicity in production and modification and the capacity to maintain function of bioactive agents. The unique mesoporous structure of silica facilitates effective loading of drugs and their subsequent controlled release. The properties of mesopores, including pore size and porosity as well as the surface properties, can be altered depending on additives used to fabricate mesoporous silica nanoparticles. Active surface enables functionalisation to modify surface properties and link therapeutic molecules. The tuneable mesopore structure and modifiable surface of mesoporous silica nanoparticle allow incorporation of various classes of drug molecules and controlled delivery to the target sites. This review aims to present the state of knowledge of currently available drug delivery system and identify properties of an ideal drug carrier for specific application, focusing on mesoporous silica nanoparticles." @default.
• W2145133103 created "2016-06-24" @default.
• W2145133103 creator A5000341662 @default.
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• W2145133103 creator A5025351605 @default.
• W2145133103 creator A5041064140 @default.
• W2145133103 creator A5056308156 @default.
• W2145133103 date "2013-01-01" @default.
• W2145133103 modified "2023-10-18" @default.
• W2145133103 title "Silica-based mesoporous nanoparticles for controlled drug delivery" @default.
• W2145133103 cites W1545939652 @default.
• W2145133103 cites W1577854799 @default.
• W2145133103 cites W1921196362 @default.
• W2145133103 cites W1935186084 @default.
• W2145133103 cites W1964107229 @default.
• W2145133103 cites W1965048019 @default.
• W2145133103 cites W1967113110 @default.
• W2145133103 cites W1968226449 @default.
• W2145133103 cites W1969040530 @default.
• W2145133103 cites W1969064599 @default.
• W2145133103 cites W1969703255 @default.
• W2145133103 cites W1971858499 @default.
• W2145133103 cites W1972017052 @default.
• W2145133103 cites W1975145454 @default.
• W2145133103 cites W1976677427 @default.
• W2145133103 cites W1976904757 @default.
• W2145133103 cites W1978913481 @default.
• W2145133103 cites W1981729675 @default.
• W2145133103 cites W1981942954 @default.
• W2145133103 cites W1982179392 @default.
• W2145133103 cites W1983159606 @default.
• W2145133103 cites W1984367237 @default.
• W2145133103 cites W1985560960 @default.
• W2145133103 cites W1989658721 @default.
• W2145133103 cites W1990132909 @default.
• W2145133103 cites W1990597311 @default.
• W2145133103 cites W1991419088 @default.
• W2145133103 cites W1991443010 @default.
• W2145133103 cites W1991693135 @default.
• W2145133103 cites W2002769519 @default.
• W2145133103 cites W2004602103 @default.
• W2145133103 cites W2004730662 @default.
• W2145133103 cites W2008989883 @default.
• W2145133103 cites W2009038500 @default.
• W2145133103 cites W2010277578 @default.
• W2145133103 cites W2012904684 @default.
• W2145133103 cites W2013013563 @default.
• W2145133103 cites W2013501667 @default.
• W2145133103 cites W2015721897 @default.
• W2145133103 cites W2018539273 @default.
• W2145133103 cites W2021743603 @default.
• W2145133103 cites W2021895540 @default.
• W2145133103 cites W2022981155 @default.
• W2145133103 cites W2023201286 @default.
• W2145133103 cites W2023662093 @default.
• W2145133103 cites W2025876657 @default.
• W2145133103 cites W2027908829 @default.
• W2145133103 cites W2028982372 @default.
• W2145133103 cites W2029202873 @default.
• W2145133103 cites W2030016605 @default.
• W2145133103 cites W2030226964 @default.
• W2145133103 cites W2030855909 @default.
• W2145133103 cites W2031478340 @default.
• W2145133103 cites W2031822535 @default.
• W2145133103 cites W2031951500 @default.
• W2145133103 cites W2032493492 @default.
• W2145133103 cites W2034602721 @default.
• W2145133103 cites W2036261157 @default.
• W2145133103 cites W2036559515 @default.
• W2145133103 cites W2038379069 @default.
• W2145133103 cites W2041204432 @default.
• W2145133103 cites W2042109441 @default.
• W2145133103 cites W2042602209 @default.
• W2145133103 cites W2042898229 @default.
• W2145133103 cites W2047037311 @default.
• W2145133103 cites W2047455295 @default.
• W2145133103 cites W2051472828 @default.
• W2145133103 cites W2055870112 @default.
• W2145133103 cites W2057647018 @default.
• W2145133103 cites W2059932608 @default.
• W2145133103 cites W2060060884 @default.
• W2145133103 cites W2065527895 @default.
• W2145133103 cites W2066156103 @default.
• W2145133103 cites W2068601472 @default.
• W2145133103 cites W2069845593 @default.
• W2145133103 cites W2070517548 @default.
• W2145133103 cites W2072864417 @default.
• W2145133103 cites W2073595990 @default.
• W2145133103 cites W2073641595 @default.
• W2145133103 cites W2074046804 @default.
• W2145133103 cites W2076417036 @default.
• W2145133103 cites W2077300098 @default.
• W2145133103 cites W2078690504 @default.
• W2145133103 cites W2081361283 @default.
• W2145133103 cites W2084202675 @default.
• W2145133103 cites W2084634726 @default.
• W2145133103 cites W2086947584 @default.

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