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• W2145144792 abstract "Background/Aims: Increased concentration of plasma tumor necrosis factor α (TNF-α) correlates with the clinical course of alcoholic liver diseases. In addition, hepatic RANTES which migrates CD4 T lymphocytes to liver is increased in patients with alcoholic hepatitis. We investigated that roles of TNF-α on RANTES expression in hepatocytes.Methods: HLE cells were treated with TNF-α in the presence, or absence of several inhibitors. Enzyme-linked immunoassay and reverse transcriptase-polymerase chain reaction were performed for the measurement of protein production and mRNA of RANTES, respectively. Moreover, DNA-binding activity of NF-κB was investigated using electrophoretic mobility shift assay. To examine effects of TNF-α on RANTES gene expression, luciferase assay was performed.Results: TNF-α clearly up-regulated RANTES expression in a time-dependent fashion and induced DNA-binding activity of NF-κB. Moreover, TNF-α-induced RANTES expression was completely inhibited by SB203580, but not calphostin C and wortmannin. Luciferase assay showed that TNF-α increased RANTES gene expression and mutation of NF-κB binding sites in the RANTES promoter ablated TNF-α inducibility.Conclusions: We showed that RANTES was transcriptionally induced in human hepatoma cells by treatment with TNF-α via activation of NF-κB and p38 MAP kinase, presumably suggesting that TNF-α-induced expression of RANTES plays important roles in cell-mediated liver injury in alcoholic liver diseases." @default.
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• W2145144792 date "2003-04-01" @default.
• W2145144792 modified "2023-10-03" @default.
• W2145144792 title "Tumor necrosis factor α (TNF-α)-induced RANTES chemokine expression via activation of NF-κB and p38 MAP kinase: roles of TNF-α in alcoholic liver diseases" @default.
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• W2145144792 doi "https://doi.org/10.1016/s0168-8278(02)00456-7" @default.
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