FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2145153889> ?p ?o ?g. }

• W2145153889 endingPage "3113" @default.
• W2145153889 startingPage "3107" @default.
• W2145153889 abstract "Induction and maintenance of peripheral tolerance is an important phenomenon for the control of homeostasis in the immune system. There is now compelling evidence for CD4(+) T cells that prevent immune pathology, both in autoimmunity and in transplantation. However, the mechanisms involved in the specific differentiation of these T cells are unknown. We had previously shown that repetitive stimulations of naive T cells in the presence of IL-10 induce the differentiation of T regulatory cells 1. We further dissected the mechanism of IL-10 function and demonstrated that IL-10 acts by the down-regulation of most costimulatory molecules without modifying the expression of CD58. Using artificial APCs expressing various costimulatory molecules, we demonstrated that, in contrast to other costimulation patterns, costimulation via CD2 alone, in the absence of costimulations through CD28- or LFA-1, induced T cell anergy in an IL-10-independent pathway along with the differentiation of Ag-specific regulatory T cells. T regulatory cell-1 differentiation via CD2 was very efficient as both high IL-10 secretion and regulatory function were observed after the first stimulation of naive T cells with CD32-CD58 L cells. The possibility to rapidly induce the differentiation of Ag-specific regulatory T cells will certainly accelerate their characterization and their potential use as regulators of T cell-mediated diseases." @default.
• W2145153889 created "2016-06-24" @default.
• W2145153889 creator A5033036738 @default.
• W2145153889 creator A5053689613 @default.
• W2145153889 creator A5090868655 @default.
• W2145153889 date "2001-09-15" @default.
• W2145153889 modified "2023-10-01" @default.
• W2145153889 title "Differentiation of Regulatory T Cells 1 Is Induced by CD2 Costimulation" @default.
• W2145153889 cites W146824947 @default.
• W2145153889 cites W1516427744 @default.
• W2145153889 cites W1517658874 @default.
• W2145153889 cites W1526621387 @default.
• W2145153889 cites W1527839934 @default.
• W2145153889 cites W1573470869 @default.
• W2145153889 cites W1578226724 @default.
• W2145153889 cites W1578777653 @default.
• W2145153889 cites W187515065 @default.
• W2145153889 cites W1960538598 @default.
• W2145153889 cites W1964264035 @default.
• W2145153889 cites W1977930748 @default.
• W2145153889 cites W1980340532 @default.
• W2145153889 cites W1981310230 @default.
• W2145153889 cites W2007455959 @default.
• W2145153889 cites W2016620180 @default.
• W2145153889 cites W2035552180 @default.
• W2145153889 cites W2049048561 @default.
• W2145153889 cites W2053189806 @default.
• W2145153889 cites W2056269106 @default.
• W2145153889 cites W2062058886 @default.
• W2145153889 cites W2065270456 @default.
• W2145153889 cites W2067353129 @default.
• W2145153889 cites W2071725107 @default.
• W2145153889 cites W2074220343 @default.
• W2145153889 cites W2083466222 @default.
• W2145153889 cites W2086195958 @default.
• W2145153889 cites W2092643850 @default.
• W2145153889 cites W2094799089 @default.
• W2145153889 cites W2096810938 @default.
• W2145153889 cites W2101771134 @default.
• W2145153889 cites W2105882150 @default.
• W2145153889 cites W2118894233 @default.
• W2145153889 cites W2128864185 @default.
• W2145153889 cites W2138961639 @default.
• W2145153889 cites W2139104516 @default.
• W2145153889 cites W2140066663 @default.
• W2145153889 cites W2150368859 @default.
• W2145153889 cites W4248534459 @default.
• W2145153889 cites W4313333836 @default.
• W2145153889 doi "https://doi.org/10.4049/jimmunol.167.6.3107" @default.
• W2145153889 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11544295" @default.
• W2145153889 hasPublicationYear "2001" @default.
• W2145153889 type Work @default.
• W2145153889 sameAs 2145153889 @default.
• W2145153889 citedByCount "92" @default.
• W2145153889 countsByYear W21451538892012 @default.
• W2145153889 countsByYear W21451538892013 @default.
• W2145153889 countsByYear W21451538892014 @default.
• W2145153889 countsByYear W21451538892015 @default.
• W2145153889 countsByYear W21451538892016 @default.
• W2145153889 countsByYear W21451538892017 @default.
• W2145153889 countsByYear W21451538892018 @default.
• W2145153889 countsByYear W21451538892019 @default.
• W2145153889 countsByYear W21451538892021 @default.
• W2145153889 countsByYear W21451538892022 @default.
• W2145153889 countsByYear W21451538892023 @default.
• W2145153889 crossrefType "journal-article" @default.
• W2145153889 hasAuthorship W2145153889A5033036738 @default.
• W2145153889 hasAuthorship W2145153889A5053689613 @default.
• W2145153889 hasAuthorship W2145153889A5090868655 @default.
• W2145153889 hasBestOaLocation W21451538891 @default.
• W2145153889 hasConcept C104317684 @default.
• W2145153889 hasConcept C148125776 @default.
• W2145153889 hasConcept C148738053 @default.
• W2145153889 hasConcept C154317977 @default.
• W2145153889 hasConcept C19317047 @default.
• W2145153889 hasConcept C202751555 @default.
• W2145153889 hasConcept C203014093 @default.
• W2145153889 hasConcept C2775982045 @default.
• W2145153889 hasConcept C2776090121 @default.
• W2145153889 hasConcept C2778296632 @default.
• W2145153889 hasConcept C54355233 @default.
• W2145153889 hasConcept C79484868 @default.
• W2145153889 hasConcept C86803240 @default.
• W2145153889 hasConcept C8891405 @default.
• W2145153889 hasConcept C95444343 @default.
• W2145153889 hasConceptScore W2145153889C104317684 @default.
• W2145153889 hasConceptScore W2145153889C148125776 @default.
• W2145153889 hasConceptScore W2145153889C148738053 @default.
• W2145153889 hasConceptScore W2145153889C154317977 @default.
• W2145153889 hasConceptScore W2145153889C19317047 @default.
• W2145153889 hasConceptScore W2145153889C202751555 @default.
• W2145153889 hasConceptScore W2145153889C203014093 @default.
• W2145153889 hasConceptScore W2145153889C2775982045 @default.
• W2145153889 hasConceptScore W2145153889C2776090121 @default.
• W2145153889 hasConceptScore W2145153889C2778296632 @default.
• W2145153889 hasConceptScore W2145153889C54355233 @default.
• W2145153889 hasConceptScore W2145153889C79484868 @default.
• W2145153889 hasConceptScore W2145153889C86803240 @default.

• next