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• W2145156632 abstract "The use of titanium dioxide nanoparticles (nano-TiO2) for the degradation of dichlorodiphenyltrichloroethane (p,p′-DDT) increases the risk of exposure to trace nano-TiO2 and p,p′-DDT mixtures. The interaction of p,p′-DDT and nano-TiO2 at low concentrations may alter toxic response relative to nano-TiO2 or p,p′-DDT alone. In this work, the combined genotoxicity of trace nano-TiO2 and p,p′-DDT on human embryo L-02 hepatocytes without photoactivation was studied. Nano-TiO2 (0.1 g/L) was mixed with 0.01–1 mmol/L p,p′-DDT to determine adsorption isotherms. L-02 cells were exposed to different levels of p,p′-DDT (0, 0.001, 0.01, and 0.1 μmol/L) and nano-TiO2 (0, 0.01, 0.1, and 1 μg/mL) respectively. The adsorption of p,p′-DDT by nano-TiO2 was approximately 0.3 mmol/g. Cell viability, apoptosis, and DNA double strand breaks were similar among all test groups. Nano-TiO2 alone (0.01–1 μg/mL) increased the levels of oxidative stress and oxidative DNA adducts (8-OHdG), but it did not induce DNA breaks or chromosome damage. Addition of trace nano-TiO2 with trace p,p′-DDT synergistically enhanced genotoxicity via increasing oxidative stress, oxidative DNA adducts, DNA breaks, and chromosome damage in L-02 cells. Low concentrations of nano-TiO2 and p,p′-DDT increased oxidativestress by reactive oxygen species (ROS) formation and lipid oxidation. Oxidative stress is a major pathway for DNA and chromosome damage. Dose-dependent synergistic genotoxicity induced by combined exposure of trace p,p′-DDT and nano-TiO2 suggests a potential environmental risk of nano-TiO2 assisted photocatalysis. Environ. Mol. Mutagen., 2010. © 2009 Wiley-Liss, Inc." @default.
• W2145156632 created "2016-06-24" @default.
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• W2145156632 date "2009-01-01" @default.
• W2145156632 modified "2023-10-17" @default.
• W2145156632 title "Synergistic genotoxicity caused by low concentration of titanium dioxide nanoparticles and<i>p,p</i>′-DDT in human hepatocytes" @default.
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• W2145156632 doi "https://doi.org/10.1002/em.20527" @default.
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