Matches in SemOpenAlex for { <https://semopenalex.org/work/W2145156694> ?p ?o ?g. }
- W2145156694 endingPage "243" @default.
- W2145156694 startingPage "231" @default.
- W2145156694 abstract "There is an immediate need for functional and molecular studies to decipher differences between disease and 'normal' settings to identify large quantities of validated targets with the highest therapeutic utilities. Furthermore, drug mechanism of action and biomarkers to predict drug efficacy and safety need to be identified for effective design of clinical trials, decreasing attrition rates, regulatory agency approval process and drug repositioning. By expanding the power of genetics and pharmacogenetics studies, next-generation nucleic acid sequencing technologies have started to play an important role in all stages of drug discovery.This article reviews the first- and second-generation sequencing technologies (SGSTs) and challenges they pose to biomedicine. The article then focuses on the emerging third-generation sequencing technologies (TGSTs), their technological foundations and potential contributions to drug discovery.Despite the scientific and commercial success of SGSTs, the goal of rapid, comprehensive and unbiased sequencing of nucleic acids has not been achieved. TGSTs promise to increase sequencing throughput and read lengths, decrease costs, run times and error rates, eliminate biases inherent in SGSTs and offer capabilities beyond nucleic acid sequencing. Such changes will have positive impact on all sequencing applications to drug discovery." @default.
- W2145156694 created "2016-06-24" @default.
- W2145156694 creator A5026875517 @default.
- W2145156694 date "2012-02-02" @default.
- W2145156694 modified "2023-10-18" @default.
- W2145156694 title "Third-generation sequencing techniques and applications to drug discovery" @default.
- W2145156694 cites W1606920356 @default.
- W2145156694 cites W1963685068 @default.
- W2145156694 cites W1964730348 @default.
- W2145156694 cites W1965175512 @default.
- W2145156694 cites W1970667469 @default.
- W2145156694 cites W1973950074 @default.
- W2145156694 cites W1974646727 @default.
- W2145156694 cites W1979072451 @default.
- W2145156694 cites W1982538875 @default.
- W2145156694 cites W1984783889 @default.
- W2145156694 cites W1987630123 @default.
- W2145156694 cites W1988929438 @default.
- W2145156694 cites W1991267416 @default.
- W2145156694 cites W1994534146 @default.
- W2145156694 cites W1996542013 @default.
- W2145156694 cites W2001725958 @default.
- W2145156694 cites W2006135398 @default.
- W2145156694 cites W2007510497 @default.
- W2145156694 cites W2009440421 @default.
- W2145156694 cites W2009886994 @default.
- W2145156694 cites W2012016911 @default.
- W2145156694 cites W2012977051 @default.
- W2145156694 cites W2017325329 @default.
- W2145156694 cites W2019189992 @default.
- W2145156694 cites W2022603493 @default.
- W2145156694 cites W2025583382 @default.
- W2145156694 cites W2027684385 @default.
- W2145156694 cites W2030692069 @default.
- W2145156694 cites W2031212650 @default.
- W2145156694 cites W2032518018 @default.
- W2145156694 cites W2041136224 @default.
- W2145156694 cites W2046137036 @default.
- W2145156694 cites W2052576920 @default.
- W2145156694 cites W2056925335 @default.
- W2145156694 cites W2059198040 @default.
- W2145156694 cites W2060423946 @default.
- W2145156694 cites W2060842569 @default.
- W2145156694 cites W2065213545 @default.
- W2145156694 cites W2066756249 @default.
- W2145156694 cites W2069985409 @default.
- W2145156694 cites W2070777085 @default.
- W2145156694 cites W2076034830 @default.
- W2145156694 cites W2076035318 @default.
- W2145156694 cites W2078884016 @default.
- W2145156694 cites W2080959314 @default.
- W2145156694 cites W2089050775 @default.
- W2145156694 cites W2090037139 @default.
- W2145156694 cites W2092784580 @default.
- W2145156694 cites W2093239605 @default.
- W2145156694 cites W2094883982 @default.
- W2145156694 cites W2101120467 @default.
- W2145156694 cites W2104890139 @default.
- W2145156694 cites W2106308757 @default.
- W2145156694 cites W2108058966 @default.
- W2145156694 cites W2110501857 @default.
- W2145156694 cites W2113649367 @default.
- W2145156694 cites W2114752404 @default.
- W2145156694 cites W2118526609 @default.
- W2145156694 cites W2119276480 @default.
- W2145156694 cites W2120572492 @default.
- W2145156694 cites W2123062855 @default.
- W2145156694 cites W2127407003 @default.
- W2145156694 cites W2128114769 @default.
- W2145156694 cites W2132341951 @default.
- W2145156694 cites W2138665978 @default.
- W2145156694 cites W2142642738 @default.
- W2145156694 cites W2149573463 @default.
- W2145156694 cites W2152805980 @default.
- W2145156694 cites W2153010521 @default.
- W2145156694 cites W2157612734 @default.
- W2145156694 cites W2160825263 @default.
- W2145156694 cites W2161273650 @default.
- W2145156694 cites W2162010421 @default.
- W2145156694 cites W2167381746 @default.
- W2145156694 cites W2169035256 @default.
- W2145156694 cites W2616754551 @default.
- W2145156694 doi "https://doi.org/10.1517/17460441.2012.660145" @default.
- W2145156694 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3319653" @default.
- W2145156694 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22468954" @default.
- W2145156694 hasPublicationYear "2012" @default.
- W2145156694 type Work @default.
- W2145156694 sameAs 2145156694 @default.
- W2145156694 citedByCount "51" @default.
- W2145156694 countsByYear W21451566942012 @default.
- W2145156694 countsByYear W21451566942013 @default.
- W2145156694 countsByYear W21451566942014 @default.
- W2145156694 countsByYear W21451566942015 @default.
- W2145156694 countsByYear W21451566942016 @default.
- W2145156694 countsByYear W21451566942018 @default.
- W2145156694 countsByYear W21451566942019 @default.
- W2145156694 countsByYear W21451566942020 @default.
- W2145156694 countsByYear W21451566942021 @default.