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- W2145172627 abstract "Injection with botulinum A exotoxin reconstituted with preserved saline has been shown to be less uncomfortable than injection with the same toxin reconstituted with preservative-free saline.We sought to determine whether injection with botulinum toxin type B is similarly less painful when preservative-containing saline is used to further dilute the product.We conducted a double-blind, randomized controlled trial. A total of 15 consecutive adult patients presenting for treatment of upper face dynamic lines received treatment to one side (left or right) of the face with toxin type B further diluted with preservative-containing saline, and to the other side with toxin type B further diluted with preservative-free saline.Of 15 patients, 13 (87%) reported less pain in the halves of their faces treated with the preservative-containing saline (P =.0006). Pain on the preservative-containing side was on average 32% less among patients as a whole, and 39% less among patients noting some reduction. The 95% confidence interval for pain reduction associated with preservative-containing injection was -46.9% to -16.1%. Neither investigators nor patients observed any difference in clinical efficacy between the 2 treatment sides.Use of preservative-containing saline to further dilute botulinum toxin type B can significantly decrease patient discomfort on injection." @default.
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- W2145172627 date "2003-06-01" @default.
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- W2145172627 title "Reduction in injection pain with botulinum toxin type B further diluted using saline with preservative: A double-blind, randomized controlled trial" @default.
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- W2145172627 doi "https://doi.org/10.1067/mjd.2003.487" @default.
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