Matches in SemOpenAlex for { <https://semopenalex.org/work/W2145193843> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2145193843 endingPage "64" @default.
- W2145193843 startingPage "758" @default.
- W2145193843 abstract "Administration to rats of the selective beta-2 adrenoceptor agonist (+/-)-clenbuterol (CLEN) (0.3 mg.kg-1 s.c., twice daily for 14 days) decreased the relaxant responses to the beta adrenoceptor agonist (-)-isoproterenol (IS) and to CLEN in KCl-contracted aortic rings. The treatment did not modify the vasodilation induced by forskolin (a direct activator of the catalytic subunit of the adenylate cyclase), 3-isobutyl-1-methylxanthine (a phosphodiesterase inhibitor), adenosine or acetylcholine. IS increased (cAMP) cyclic AMP levels dose-dependently in rat aorta, and this effect was reduced markedly in arteries from CLEN-treated rats. By contrast, the treatment did not modify the forskolin-induced cAMP production. The contractile response to (-)-norepinephrine (NE) was inhibited in the presence of IS or CLEN in control aortic rings. However, this modulatory effect was not seen in arteries from CLEN-treated rats. Preincubation of the arteries with either cholera toxin (an activator of the stimulatory guanine nucleotide binding protein, Gs) or forskolin reduced NE-induced vasoconstriction to the same extent in aortic rings from both control and CLEN-treated rats. The chronotropic response to NE in rat atria (beta-1-mediated) was not affected by the treatment. These results suggest that prolonged administration of CLEN to rats induced desensitization of beta-2 adrenoceptor-mediated vascular relaxation by alterations at the level of the beta-2 adrenergic receptor, but not in the mechanisms related to Gs, adenylate cyclase or in those distal to cAMP production." @default.
- W2145193843 created "2016-06-24" @default.
- W2145193843 creator A5029548499 @default.
- W2145193843 creator A5051611736 @default.
- W2145193843 date "1990-02-01" @default.
- W2145193843 modified "2023-10-17" @default.
- W2145193843 title "Desensitization of the beta-2 adrenoceptor-mediated vasodilation in rat aorta after prolonged treatment with the beta-2 adrenoceptor agonist clenbuterol." @default.
- W2145193843 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2156060" @default.
- W2145193843 hasPublicationYear "1990" @default.
- W2145193843 type Work @default.
- W2145193843 sameAs 2145193843 @default.
- W2145193843 citedByCount "5" @default.
- W2145193843 countsByYear W21451938432014 @default.
- W2145193843 countsByYear W21451938432022 @default.
- W2145193843 crossrefType "journal-article" @default.
- W2145193843 hasAuthorship W2145193843A5029548499 @default.
- W2145193843 hasAuthorship W2145193843A5051611736 @default.
- W2145193843 hasConcept C120770815 @default.
- W2145193843 hasConcept C126322002 @default.
- W2145193843 hasConcept C134018914 @default.
- W2145193843 hasConcept C158328960 @default.
- W2145193843 hasConcept C170493617 @default.
- W2145193843 hasConcept C185592680 @default.
- W2145193843 hasConcept C24998067 @default.
- W2145193843 hasConcept C2776766087 @default.
- W2145193843 hasConcept C2776991684 @default.
- W2145193843 hasConcept C2777953023 @default.
- W2145193843 hasConcept C2778151854 @default.
- W2145193843 hasConcept C2778938600 @default.
- W2145193843 hasConcept C2779178603 @default.
- W2145193843 hasConcept C2779276759 @default.
- W2145193843 hasConcept C2779961880 @default.
- W2145193843 hasConcept C2780069284 @default.
- W2145193843 hasConcept C71924100 @default.
- W2145193843 hasConcept C84393581 @default.
- W2145193843 hasConcept C86803240 @default.
- W2145193843 hasConceptScore W2145193843C120770815 @default.
- W2145193843 hasConceptScore W2145193843C126322002 @default.
- W2145193843 hasConceptScore W2145193843C134018914 @default.
- W2145193843 hasConceptScore W2145193843C158328960 @default.
- W2145193843 hasConceptScore W2145193843C170493617 @default.
- W2145193843 hasConceptScore W2145193843C185592680 @default.
- W2145193843 hasConceptScore W2145193843C24998067 @default.
- W2145193843 hasConceptScore W2145193843C2776766087 @default.
- W2145193843 hasConceptScore W2145193843C2776991684 @default.
- W2145193843 hasConceptScore W2145193843C2777953023 @default.
- W2145193843 hasConceptScore W2145193843C2778151854 @default.
- W2145193843 hasConceptScore W2145193843C2778938600 @default.
- W2145193843 hasConceptScore W2145193843C2779178603 @default.
- W2145193843 hasConceptScore W2145193843C2779276759 @default.
- W2145193843 hasConceptScore W2145193843C2779961880 @default.
- W2145193843 hasConceptScore W2145193843C2780069284 @default.
- W2145193843 hasConceptScore W2145193843C71924100 @default.
- W2145193843 hasConceptScore W2145193843C84393581 @default.
- W2145193843 hasConceptScore W2145193843C86803240 @default.
- W2145193843 hasIssue "2" @default.
- W2145193843 hasLocation W21451938431 @default.
- W2145193843 hasOpenAccess W2145193843 @default.
- W2145193843 hasPrimaryLocation W21451938431 @default.
- W2145193843 hasRelatedWork W1992873995 @default.
- W2145193843 hasRelatedWork W2012436520 @default.
- W2145193843 hasRelatedWork W2023819370 @default.
- W2145193843 hasRelatedWork W2027715377 @default.
- W2145193843 hasRelatedWork W2041447987 @default.
- W2145193843 hasRelatedWork W2068769544 @default.
- W2145193843 hasRelatedWork W2140904265 @default.
- W2145193843 hasRelatedWork W2145193843 @default.
- W2145193843 hasRelatedWork W2336741278 @default.
- W2145193843 hasRelatedWork W2400478045 @default.
- W2145193843 hasVolume "252" @default.
- W2145193843 isParatext "false" @default.
- W2145193843 isRetracted "false" @default.
- W2145193843 magId "2145193843" @default.
- W2145193843 workType "article" @default.