FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2145210590> ?p ?o ?g. }

• W2145210590 abstract "Abstract Background The TolC protein from Sinorhizobium meliloti has previously been demonstrated to be required for establishing successful biological nitrogen fixation symbiosis with Medicago sativa . It is also needed in protein and exopolysaccharide secretion and for protection against osmotic and oxidative stresses. Here, the transcriptional profile of free-living S. meliloti 1021 tolC mutant is described as a step toward understanding its role in the physiology of the cell. Results Comparison of tolC mutant and wild-type strains transcriptomes showed 1177 genes with significantly increased expression while 325 had significantly decreased expression levels. The genes with an increased expression suggest the activation of a cytoplasmic and extracytoplasmic stress responses possibly mediated by the sigma factor RpoH1 and protein homologues of the CpxRA two-component regulatory system of Enterobacteria, respectively. Stress conditions are probably caused by perturbation of the cell envelope. Consistent with gene expression data, biochemical analysis indicates that the tolC mutant suffers from oxidative stress. This is illustrated by the elevated enzyme activity levels detected for catalase, superoxide dismutase and glutathione reductase. The observed increase in the expression of genes encoding products involved in central metabolism and transporters for nutrient uptake suggests a higher metabolic rate of the tolC mutant. We also demonstrated increased swarming motility in the tolC mutant strain. Absence of functional TolC caused decreased expression mainly of genes encoding products involved in nitrogen metabolism and transport. Conclusion This work shows how a mutation in the outer membrane protein TolC, common to many bacterial transport systems, affects expression of a large number of genes that act in concert to restore cell homeostasis. This finding further underlines the fundamental role of this protein in Sinorhizobium meliloti biology." @default.
• W2145210590 created "2016-06-24" @default.
• W2145210590 creator A5002673515 @default.
• W2145210590 creator A5042879336 @default.
• W2145210590 creator A5066298395 @default.
• W2145210590 creator A5077203008 @default.
• W2145210590 creator A5085055981 @default.
• W2145210590 creator A5090917222 @default.
• W2145210590 date "2010-06-23" @default.
• W2145210590 modified "2023-09-23" @default.
• W2145210590 title "Absence of functional TolC protein causes increased stress response gene expression in Sinorhizobium meliloti" @default.
• W2145210590 cites W1501095088 @default.
• W2145210590 cites W1553669032 @default.
• W2145210590 cites W1801547473 @default.
• W2145210590 cites W1875467197 @default.
• W2145210590 cites W1942502379 @default.
• W2145210590 cites W1986818807 @default.
• W2145210590 cites W1993623585 @default.
• W2145210590 cites W2000323554 @default.
• W2145210590 cites W2000974199 @default.
• W2145210590 cites W2012218328 @default.
• W2145210590 cites W2015764777 @default.
• W2145210590 cites W2018120938 @default.
• W2145210590 cites W2018875196 @default.
• W2145210590 cites W2022685972 @default.
• W2145210590 cites W2027016294 @default.
• W2145210590 cites W2027084136 @default.
• W2145210590 cites W2030015794 @default.
• W2145210590 cites W2032054300 @default.
• W2145210590 cites W2033875071 @default.
• W2145210590 cites W2038437697 @default.
• W2145210590 cites W2039291412 @default.
• W2145210590 cites W2042500544 @default.
• W2145210590 cites W2047222805 @default.
• W2145210590 cites W2049353359 @default.
• W2145210590 cites W2059513932 @default.
• W2145210590 cites W2071037031 @default.
• W2145210590 cites W2075325890 @default.
• W2145210590 cites W2075641785 @default.
• W2145210590 cites W2093869152 @default.
• W2145210590 cites W2100543621 @default.
• W2145210590 cites W2101021971 @default.
• W2145210590 cites W2102855875 @default.
• W2145210590 cites W2108244474 @default.
• W2145210590 cites W2108566880 @default.
• W2145210590 cites W2110603599 @default.
• W2145210590 cites W2112586763 @default.
• W2145210590 cites W2112634425 @default.
• W2145210590 cites W2112802256 @default.
• W2145210590 cites W2115023451 @default.
• W2145210590 cites W2118169991 @default.
• W2145210590 cites W2118225130 @default.
• W2145210590 cites W2118608067 @default.
• W2145210590 cites W2124307834 @default.
• W2145210590 cites W2133342418 @default.
• W2145210590 cites W2134177205 @default.
• W2145210590 cites W2139543196 @default.
• W2145210590 cites W2143913812 @default.
• W2145210590 cites W2145441064 @default.
• W2145210590 cites W2146731040 @default.
• W2145210590 cites W2150331512 @default.
• W2145210590 cites W2158941341 @default.
• W2145210590 cites W2159742735 @default.
• W2145210590 cites W2167556437 @default.
• W2145210590 cites W2168702835 @default.
• W2145210590 cites W2169586133 @default.
• W2145210590 cites W4293247451 @default.
• W2145210590 doi "https://doi.org/10.1186/1471-2180-10-180" @default.
• W2145210590 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2912261" @default.
• W2145210590 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20573193" @default.
• W2145210590 hasPublicationYear "2010" @default.
• W2145210590 type Work @default.
• W2145210590 sameAs 2145210590 @default.
• W2145210590 citedByCount "34" @default.
• W2145210590 countsByYear W21452105902012 @default.
• W2145210590 countsByYear W21452105902013 @default.
• W2145210590 countsByYear W21452105902014 @default.
• W2145210590 countsByYear W21452105902015 @default.
• W2145210590 countsByYear W21452105902016 @default.
• W2145210590 countsByYear W21452105902017 @default.
• W2145210590 countsByYear W21452105902018 @default.
• W2145210590 countsByYear W21452105902019 @default.
• W2145210590 countsByYear W21452105902021 @default.
• W2145210590 countsByYear W21452105902022 @default.
• W2145210590 countsByYear W21452105902023 @default.
• W2145210590 crossrefType "journal-article" @default.
• W2145210590 hasAuthorship W2145210590A5002673515 @default.
• W2145210590 hasAuthorship W2145210590A5042879336 @default.
• W2145210590 hasAuthorship W2145210590A5066298395 @default.
• W2145210590 hasAuthorship W2145210590A5077203008 @default.
• W2145210590 hasAuthorship W2145210590A5085055981 @default.
• W2145210590 hasAuthorship W2145210590A5090917222 @default.
• W2145210590 hasBestOaLocation W21452105901 @default.
• W2145210590 hasConcept C101762097 @default.
• W2145210590 hasConcept C104317684 @default.
• W2145210590 hasConcept C143065580 @default.
• W2145210590 hasConcept C146587185 @default.
• W2145210590 hasConcept C150194340 @default.
• W2145210590 hasConcept C2777304268 @default.
• W2145210590 hasConcept C47319516 @default.

• next