Matches in SemOpenAlex for { <https://semopenalex.org/work/W2145220202> ?p ?o ?g. }
- W2145220202 endingPage "1580" @default.
- W2145220202 startingPage "1570" @default.
- W2145220202 abstract "The maxi-anion channel has been observed in many cell types from the very beginning of the patch-clamp era. The channel is highly conductive for chloride and thus can modulate the resting membrane potential and play a role in fluid secretion/absorption and cell volume regulation. A wide nanoscopic pore of the maxi-anion channel permits passage of excitatory amino acids and nucleotides. The channel-mediated release of these signaling molecules is associated with kidney tubuloglomerular feedback, cardiac ischemia/hypoxia, as well as brain ischemia/hypoxia and excitotoxic neurodegeneration. Despite the ubiquitous expression and physiological/pathophysiological significance, the molecular identity of the maxi-anion channel is still obscure. VDAC is primarily a mitochondrial protein; however several groups detected it on the cellular surface. VDAC in lipid bilayers reproduced the most important biophysical properties of the maxi-anion channel, such as a wide nano-sized pore, closure in response to moderately high voltages, ATP-block and ATP-permeability. However, these similarities turned out to be superficial, and the hypothesis of plasmalemmal VDAC as the maxi-anion channel did not withstand the test by genetic manipulations of VDAC protein expression. VDAC on the cellular surface could also function as a ferricyanide reductase or a receptor for plasminogen kringle 5 and for neuroactive steroids. These ideas, as well as the very presence of VDAC on plasmalemma, remain to be scrutinized by genetic manipulations of the VDAC protein expression. This article is part of a Special Issue entitled: VDAC structure, function, and regulation of mitochondrial metabolism." @default.
- W2145220202 created "2016-06-24" @default.
- W2145220202 creator A5022916983 @default.
- W2145220202 creator A5027026994 @default.
- W2145220202 date "2012-06-01" @default.
- W2145220202 modified "2023-09-27" @default.
- W2145220202 title "Plasmalemmal VDAC controversies and maxi-anion channel puzzle" @default.
- W2145220202 cites W1496797348 @default.
- W2145220202 cites W1499538911 @default.
- W2145220202 cites W1562561022 @default.
- W2145220202 cites W1572881340 @default.
- W2145220202 cites W1575666495 @default.
- W2145220202 cites W1601744083 @default.
- W2145220202 cites W1603526957 @default.
- W2145220202 cites W1845648639 @default.
- W2145220202 cites W1913353167 @default.
- W2145220202 cites W1963761882 @default.
- W2145220202 cites W1965122083 @default.
- W2145220202 cites W1968304355 @default.
- W2145220202 cites W1969697935 @default.
- W2145220202 cites W1970358900 @default.
- W2145220202 cites W1974608857 @default.
- W2145220202 cites W1975910482 @default.
- W2145220202 cites W1978460559 @default.
- W2145220202 cites W1980041137 @default.
- W2145220202 cites W1980496535 @default.
- W2145220202 cites W1980521417 @default.
- W2145220202 cites W1980826368 @default.
- W2145220202 cites W1981337695 @default.
- W2145220202 cites W1982928579 @default.
- W2145220202 cites W1987148981 @default.
- W2145220202 cites W1988917342 @default.
- W2145220202 cites W1990011053 @default.
- W2145220202 cites W1991143182 @default.
- W2145220202 cites W1991158727 @default.
- W2145220202 cites W1991870376 @default.
- W2145220202 cites W1991931009 @default.
- W2145220202 cites W1993233157 @default.
- W2145220202 cites W1993862603 @default.
- W2145220202 cites W199440580 @default.
- W2145220202 cites W1996051526 @default.
- W2145220202 cites W1996659146 @default.
- W2145220202 cites W1997166409 @default.
- W2145220202 cites W1999391879 @default.
- W2145220202 cites W2001386885 @default.
- W2145220202 cites W2004167073 @default.
- W2145220202 cites W2006277432 @default.
- W2145220202 cites W2007552499 @default.
- W2145220202 cites W2008560382 @default.
- W2145220202 cites W2008698641 @default.
- W2145220202 cites W2010897060 @default.
- W2145220202 cites W2011946852 @default.
- W2145220202 cites W2013274986 @default.
- W2145220202 cites W2015055238 @default.
- W2145220202 cites W2015533291 @default.
- W2145220202 cites W2015847948 @default.
- W2145220202 cites W2016078307 @default.
- W2145220202 cites W2017398538 @default.
- W2145220202 cites W2018855193 @default.
- W2145220202 cites W2022394608 @default.
- W2145220202 cites W2023211042 @default.
- W2145220202 cites W2025303646 @default.
- W2145220202 cites W2026227988 @default.
- W2145220202 cites W2026829929 @default.
- W2145220202 cites W2028773449 @default.
- W2145220202 cites W2028786726 @default.
- W2145220202 cites W2030088742 @default.
- W2145220202 cites W2030349442 @default.
- W2145220202 cites W2030542406 @default.
- W2145220202 cites W2030715005 @default.
- W2145220202 cites W2033029218 @default.
- W2145220202 cites W2039279644 @default.
- W2145220202 cites W2039606438 @default.
- W2145220202 cites W2040070178 @default.
- W2145220202 cites W2040155866 @default.
- W2145220202 cites W2043033643 @default.
- W2145220202 cites W2044553933 @default.
- W2145220202 cites W2047178612 @default.
- W2145220202 cites W2047691416 @default.
- W2145220202 cites W2048116734 @default.
- W2145220202 cites W2048702719 @default.
- W2145220202 cites W2049031192 @default.
- W2145220202 cites W2050215425 @default.
- W2145220202 cites W2051742147 @default.
- W2145220202 cites W2052146347 @default.
- W2145220202 cites W2057312381 @default.
- W2145220202 cites W2059237037 @default.
- W2145220202 cites W2062967090 @default.
- W2145220202 cites W2065409749 @default.
- W2145220202 cites W2067927805 @default.
- W2145220202 cites W2068002731 @default.
- W2145220202 cites W2073042805 @default.
- W2145220202 cites W2073249835 @default.
- W2145220202 cites W2073341934 @default.
- W2145220202 cites W2073557602 @default.
- W2145220202 cites W2075338442 @default.
- W2145220202 cites W2076458129 @default.
- W2145220202 cites W2077807251 @default.