FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2145226020> ?p ?o ?g. }

• W2145226020 endingPage "5567" @default.
• W2145226020 startingPage "5558" @default.
• W2145226020 abstract "Abstract Lymph node blood vessels play important roles in the support and trafficking of immune cells. The blood vasculature is a component of the vascular–stromal compartment that also includes the lymphatic vasculature and fibroblastic reticular cells (FRCs). During immune responses as lymph nodes swell, the blood vasculature undergoes a rapid proliferative growth that is initially dependent on CD11c+ cells and vascular endothelial growth factor (VEGF) but is independent of lymphocytes. The lymphatic vasculature grows with similar kinetics and VEGF dependence, suggesting coregulation of blood and lymphatic vascular growth, but lymphatic growth has been shown to be B cell dependent. In this article, we show that blood vascular, lymphatic, and FRC growth are coordinately regulated and identify two distinct phases of vascular–stromal growth—an initiation phase, characterized by upregulated vascular–stromal proliferation, and a subsequent expansion phase. The initiation phase is CD11c+ cell dependent and T/B cell independent, whereas the expansion phase is dependent on B and T cells together. Using CCR7−/− mice and selective depletion of migratory skin dendritic cells, we show that endogenous skin-derived dendritic cells are not important during the initiation phase and uncover a modest regulatory role for CCR7. Finally, we show that FRC VEGF expression is upregulated during initiation and that dendritic cells can stimulate increased fibroblastic VEGF, suggesting the scenario that lymph node-resident CD11c+ cells orchestrate the initiation of blood and lymphatic vascular growth in part by stimulating FRCs to upregulate VEGF. These results illustrate how the lymph node microenvironment is shaped by the cells it supports." @default.
• W2145226020 created "2016-06-24" @default.
• W2145226020 creator A5014999157 @default.
• W2145226020 creator A5015612058 @default.
• W2145226020 creator A5034640049 @default.
• W2145226020 creator A5049192317 @default.
• W2145226020 creator A5055855758 @default.
• W2145226020 creator A5067529822 @default.
• W2145226020 creator A5084302554 @default.
• W2145226020 date "2011-12-01" @default.
• W2145226020 modified "2023-10-18" @default.
• W2145226020 title "Coordinated Regulation of Lymph Node Vascular–Stromal Growth First by CD11c+ Cells and Then by T and B Cells" @default.
• W2145226020 cites W1519030262 @default.
• W2145226020 cites W1930259420 @default.
• W2145226020 cites W1965985032 @default.
• W2145226020 cites W1967051290 @default.
• W2145226020 cites W1967994686 @default.
• W2145226020 cites W1971717482 @default.
• W2145226020 cites W1972854067 @default.
• W2145226020 cites W1977094975 @default.
• W2145226020 cites W1978219808 @default.
• W2145226020 cites W1982322400 @default.
• W2145226020 cites W1982715427 @default.
• W2145226020 cites W1987838854 @default.
• W2145226020 cites W1988338839 @default.
• W2145226020 cites W1988620205 @default.
• W2145226020 cites W1995595526 @default.
• W2145226020 cites W2007221590 @default.
• W2145226020 cites W2016055373 @default.
• W2145226020 cites W2022950716 @default.
• W2145226020 cites W2027834446 @default.
• W2145226020 cites W2035356610 @default.
• W2145226020 cites W2040472993 @default.
• W2145226020 cites W2040883799 @default.
• W2145226020 cites W2049398130 @default.
• W2145226020 cites W2053583666 @default.
• W2145226020 cites W2062101121 @default.
• W2145226020 cites W2063239613 @default.
• W2145226020 cites W2065114044 @default.
• W2145226020 cites W2068838772 @default.
• W2145226020 cites W2074118418 @default.
• W2145226020 cites W2076397065 @default.
• W2145226020 cites W2078710631 @default.
• W2145226020 cites W2079372567 @default.
• W2145226020 cites W2080737275 @default.
• W2145226020 cites W2080798548 @default.
• W2145226020 cites W2081487051 @default.
• W2145226020 cites W2083872083 @default.
• W2145226020 cites W2088811125 @default.
• W2145226020 cites W2090661916 @default.
• W2145226020 cites W2097302710 @default.
• W2145226020 cites W2102252358 @default.
• W2145226020 cites W2106962511 @default.
• W2145226020 cites W2108080714 @default.
• W2145226020 cites W2108237409 @default.
• W2145226020 cites W2114780139 @default.
• W2145226020 cites W2125533152 @default.
• W2145226020 cites W2129112743 @default.
• W2145226020 cites W2129419329 @default.
• W2145226020 cites W2131878781 @default.
• W2145226020 cites W2134254929 @default.
• W2145226020 cites W2137283587 @default.
• W2145226020 cites W2140489687 @default.
• W2145226020 cites W2147299114 @default.
• W2145226020 cites W2150959582 @default.
• W2145226020 cites W2154999756 @default.
• W2145226020 cites W2156489752 @default.
• W2145226020 cites W2158073790 @default.
• W2145226020 cites W2166588660 @default.
• W2145226020 cites W2167733085 @default.
• W2145226020 cites W2168628444 @default.
• W2145226020 cites W2169390260 @default.
• W2145226020 doi "https://doi.org/10.4049/jimmunol.1101724" @default.
• W2145226020 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3221869" @default.
• W2145226020 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22031764" @default.
• W2145226020 hasPublicationYear "2011" @default.
• W2145226020 type Work @default.
• W2145226020 sameAs 2145226020 @default.
• W2145226020 citedByCount "108" @default.
• W2145226020 countsByYear W21452260202012 @default.
• W2145226020 countsByYear W21452260202013 @default.
• W2145226020 countsByYear W21452260202014 @default.
• W2145226020 countsByYear W21452260202015 @default.
• W2145226020 countsByYear W21452260202016 @default.
• W2145226020 countsByYear W21452260202017 @default.
• W2145226020 countsByYear W21452260202018 @default.
• W2145226020 countsByYear W21452260202019 @default.
• W2145226020 countsByYear W21452260202020 @default.
• W2145226020 countsByYear W21452260202021 @default.
• W2145226020 countsByYear W21452260202022 @default.
• W2145226020 countsByYear W21452260202023 @default.
• W2145226020 crossrefType "journal-article" @default.
• W2145226020 hasAuthorship W2145226020A5014999157 @default.
• W2145226020 hasAuthorship W2145226020A5015612058 @default.
• W2145226020 hasAuthorship W2145226020A5034640049 @default.
• W2145226020 hasAuthorship W2145226020A5049192317 @default.
• W2145226020 hasAuthorship W2145226020A5055855758 @default.
• W2145226020 hasAuthorship W2145226020A5067529822 @default.

• next