FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2145253256> ?p ?o ?g. }

• W2145253256 endingPage "4282" @default.
• W2145253256 startingPage "4266" @default.
• W2145253256 abstract "The hypothesis that BMPs (bone morphogenetic proteins), which act early in gut morphogenesis, also regulate specification and differentiation in the developing enteric nervous system (ENS) was tested. Expression of BMP-2 and BMP-4, BMPR-IA (BMP receptor subunit), BMPR-IB, and BMPR-II, and the BMP antagonists, noggin, gremlin, chordin, and follistatin was found when neurons first appear in the primordial bowel at embryonic day 12 (E12). Agonists, receptors, and antagonists were detected in separated populations of neural crest- and noncrest-derived cells. When applied to immunopurified E12 ENS precursors, BMP-2 and BMP-4 induced nuclear translocation of phosphorylated Smad-1 (Sma and Mad-related protein). The number of neurons developing from these cells was increased by low concentrations and decreased by high concentrations of BMP-2 or BMP-4. BMPs induced the precocious appearance of TrkC-expressing neurons and their dependence on neurotrophin-3 for survival. BMP-4 interacted with glial cell line-derived neurotrophic factor (GDNF) to enhance neuronal development but limited GDNF-driven expansion of the precursor pool. BMPs also promoted development of smooth muscle from mesenchymal cells immunopurified at E12. To determine the physiological significance of these observations, the BMP antagonist noggin was overexpressed in the developing ENS of transgenic mice under the control of the neuron-specific enolase promoter. Neuronal numbers in both enteric plexuses and smooth muscle were increased throughout the postnatal small intestine. These increases were already apparent by E18. In contrast, TrkC-expressing neurons decreased in both plexuses of postnatal noggin-overexpressing animals, again an effect detectable at E18. BMP-2 and/or BMP-4 thus limit the size of the ENS but promote the development of specific subsets of enteric neurons, including those that express TrkC." @default.
• W2145253256 created "2016-06-24" @default.
• W2145253256 creator A5002319415 @default.
• W2145253256 creator A5009327463 @default.
• W2145253256 creator A5019329770 @default.
• W2145253256 creator A5029832154 @default.
• W2145253256 creator A5035941025 @default.
• W2145253256 creator A5046150961 @default.
• W2145253256 creator A5060695244 @default.
• W2145253256 creator A5061606548 @default.
• W2145253256 creator A5071235302 @default.
• W2145253256 creator A5071532519 @default.
• W2145253256 creator A5087013195 @default.
• W2145253256 date "2004-04-28" @default.
• W2145253256 modified "2023-10-05" @default.
• W2145253256 title "Bone Morphogenetic Protein-2 and -4 Limit the Number of Enteric Neurons But Promote Development of a TrkC-Expressing Neurotrophin-3-Dependent Subset" @default.
• W2145253256 cites W1259302142 @default.
• W2145253256 cites W1485371658 @default.
• W2145253256 cites W1491527820 @default.
• W2145253256 cites W1521180176 @default.
• W2145253256 cites W1530364143 @default.
• W2145253256 cites W1590974871 @default.
• W2145253256 cites W1609684706 @default.
• W2145253256 cites W1720193968 @default.
• W2145253256 cites W1750016221 @default.
• W2145253256 cites W1916345350 @default.
• W2145253256 cites W1965411509 @default.
• W2145253256 cites W1965514530 @default.
• W2145253256 cites W1965587751 @default.
• W2145253256 cites W1967156795 @default.
• W2145253256 cites W1967573239 @default.
• W2145253256 cites W1969126053 @default.
• W2145253256 cites W1972869928 @default.
• W2145253256 cites W1975033567 @default.
• W2145253256 cites W1978202073 @default.
• W2145253256 cites W1979185250 @default.
• W2145253256 cites W1979518793 @default.
• W2145253256 cites W1980473444 @default.
• W2145253256 cites W1981135758 @default.
• W2145253256 cites W1981422071 @default.
• W2145253256 cites W1984760520 @default.
• W2145253256 cites W1984838392 @default.
• W2145253256 cites W1985467463 @default.
• W2145253256 cites W1987566228 @default.
• W2145253256 cites W1993496211 @default.
• W2145253256 cites W2001632160 @default.
• W2145253256 cites W2005707140 @default.
• W2145253256 cites W2007092780 @default.
• W2145253256 cites W2010619614 @default.
• W2145253256 cites W2010749425 @default.
• W2145253256 cites W2012750813 @default.
• W2145253256 cites W2013290065 @default.
• W2145253256 cites W2014078232 @default.
• W2145253256 cites W2018289835 @default.
• W2145253256 cites W2019951086 @default.
• W2145253256 cites W2023718751 @default.
• W2145253256 cites W2025054473 @default.
• W2145253256 cites W2026118162 @default.
• W2145253256 cites W2027322371 @default.
• W2145253256 cites W2027723326 @default.
• W2145253256 cites W2028093783 @default.
• W2145253256 cites W2028442951 @default.
• W2145253256 cites W2031825480 @default.
• W2145253256 cites W2032197145 @default.
• W2145253256 cites W2032996236 @default.
• W2145253256 cites W2036834043 @default.
• W2145253256 cites W2040773128 @default.
• W2145253256 cites W2043072647 @default.
• W2145253256 cites W2045253310 @default.
• W2145253256 cites W2045804062 @default.
• W2145253256 cites W2050739562 @default.
• W2145253256 cites W2051998916 @default.
• W2145253256 cites W2052170081 @default.
• W2145253256 cites W2055110202 @default.
• W2145253256 cites W2055277001 @default.
• W2145253256 cites W2060895075 @default.
• W2145253256 cites W2061740313 @default.
• W2145253256 cites W2066021890 @default.
• W2145253256 cites W2071130833 @default.
• W2145253256 cites W2075945988 @default.
• W2145253256 cites W2076776277 @default.
• W2145253256 cites W2082584428 @default.
• W2145253256 cites W2085519066 @default.
• W2145253256 cites W2086315177 @default.
• W2145253256 cites W2087337416 @default.
• W2145253256 cites W2089348287 @default.
• W2145253256 cites W2094885349 @default.
• W2145253256 cites W2098976206 @default.
• W2145253256 cites W2100837269 @default.
• W2145253256 cites W2100939730 @default.
• W2145253256 cites W2104593931 @default.
• W2145253256 cites W2106215482 @default.
• W2145253256 cites W2109329255 @default.
• W2145253256 cites W2110332270 @default.
• W2145253256 cites W2111524583 @default.
• W2145253256 cites W2113272099 @default.
• W2145253256 cites W2115438940 @default.
• W2145253256 cites W2115444433 @default.

• next