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• W2145270420 startingPage "853" @default.
• W2145270420 abstract "The long-range communication of information, exemplified by signal transduction through membrane-bound receptors, is a central biochemical function. Reversible binding of a messenger ligand induces a local conformational change that is relayed through the receptor, inducing a chemical effect typically several nanometres from the binding site. We report a synthetic receptor mimic that transmits structural information from a boron-based ligand binding site to a spectroscopic reporter located more than 2 nm away. Reversible binding of a diol ligand to the N-terminal binding site induces a screw-sense preference in a helical oligo(aminoisobutyric acid) foldamer, which is relayed to a reporter group at the remote C-terminus, communicating information about the structure and stereochemistry of the ligand. The reversible nature of boronate esterification was exploited to switch the receptor sequentially between left- and right-handed helices, while the exquisite conformational sensitivity of the helical relay allowed the reporter to differentiate even between purine and pyrimidine nucleosides as ligands." @default.
• W2145270420 created "2016-06-24" @default.
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• W2145270420 date "2013-09-15" @default.
• W2145270420 modified "2023-10-18" @default.
• W2145270420 title "End-to-end conformational communication through a synthetic purinergic receptor by ligand-induced helicity switching" @default.
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• W2145270420 doi "https://doi.org/10.1038/nchem.1747" @default.
• W2145270420 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24056342" @default.
• W2145270420 hasPublicationYear "2013" @default.
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