FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2145274886> ?p ?o ?g. }

• W2145274886 endingPage "e27875" @default.
• W2145274886 startingPage "e27875" @default.
• W2145274886 abstract "Multiple sclerosis (MS) is a demyelinating and neuroinflammatory disease of the human central nervous system (CNS). The expression of kinins is increased in MS patients, but the underlying mechanisms by which the kinin receptor regulates MS development have not been elucidated.Experimental autoimmune encephalomyelitis (EAE) was induced in female C57BL/6 mice by immunization with MOG(35-55) peptide emulsified in complete Freund's adjuvant and injected with pertussis toxin on day 0 and day 2. Here, we report that blockade of the B(1)R in the induction phase of EAE markedly suppressed its progression by interfering with the onset of the immune response. Furthermore, B(1)R antagonist suppressed the production/expression of antigen-specific T(H)1 and T(H)17 cytokines and transcription factors, both in the periphery and in the CNS. In the chronic phase of EAE, the blockade of B(1)R consistently impaired the clinical progression of EAE. Conversely, administration of the B(1)R agonist in the acute phase of EAE suppressed disease progression and inhibited the increase in permeability of the blood-brain barrier (BBB) and any further CNS inflammation. Of note, blockade of the B(2)R only showed a moderate impact on all of the studied parameters of EAE progression.Our results strongly suggest that kinin receptors, mainly the B(1)R subtype, play a dual role in EAE progression depending on the phase of treatment through the lymphocytes and glial cell-dependent pathways." @default.
• W2145274886 created "2016-06-24" @default.
• W2145274886 creator A5004326476 @default.
• W2145274886 creator A5031949605 @default.
• W2145274886 creator A5038260780 @default.
• W2145274886 creator A5043712906 @default.
• W2145274886 creator A5044729242 @default.
• W2145274886 creator A5067334052 @default.
• W2145274886 creator A5079922285 @default.
• W2145274886 creator A5085571373 @default.
• W2145274886 date "2011-11-22" @default.
• W2145274886 modified "2023-10-01" @default.
• W2145274886 title "The Role of Kinin Receptors in Preventing Neuroinflammation and Its Clinical Severity during Experimental Autoimmune Encephalomyelitis in Mice" @default.
• W2145274886 cites W1485009620 @default.
• W2145274886 cites W1499813463 @default.
• W2145274886 cites W1622357346 @default.
• W2145274886 cites W1963756597 @default.
• W2145274886 cites W1968369239 @default.
• W2145274886 cites W1970842205 @default.
• W2145274886 cites W1974218877 @default.
• W2145274886 cites W1977588829 @default.
• W2145274886 cites W1983754832 @default.
• W2145274886 cites W1985599259 @default.
• W2145274886 cites W1985775190 @default.
• W2145274886 cites W1986173197 @default.
• W2145274886 cites W1992237388 @default.
• W2145274886 cites W1992883702 @default.
• W2145274886 cites W1995991167 @default.
• W2145274886 cites W1999768705 @default.
• W2145274886 cites W2000087476 @default.
• W2145274886 cites W2011923274 @default.
• W2145274886 cites W2012296014 @default.
• W2145274886 cites W2025732446 @default.
• W2145274886 cites W2029336069 @default.
• W2145274886 cites W2031880075 @default.
• W2145274886 cites W2035175031 @default.
• W2145274886 cites W2038222038 @default.
• W2145274886 cites W2049372707 @default.
• W2145274886 cites W2051412689 @default.
• W2145274886 cites W2054254705 @default.
• W2145274886 cites W2055237906 @default.
• W2145274886 cites W2058643007 @default.
• W2145274886 cites W2065186655 @default.
• W2145274886 cites W2069539795 @default.
• W2145274886 cites W2073165486 @default.
• W2145274886 cites W2073494847 @default.
• W2145274886 cites W2079404351 @default.
• W2145274886 cites W2080693320 @default.
• W2145274886 cites W2082789655 @default.
• W2145274886 cites W2083496862 @default.
• W2145274886 cites W2083820494 @default.
• W2145274886 cites W2085412596 @default.
• W2145274886 cites W2094748532 @default.
• W2145274886 cites W2107277218 @default.
• W2145274886 cites W2108594435 @default.
• W2145274886 cites W2113291839 @default.
• W2145274886 cites W2122082443 @default.
• W2145274886 cites W2143669305 @default.
• W2145274886 cites W2146779078 @default.
• W2145274886 cites W2148390754 @default.
• W2145274886 cites W2150693596 @default.
• W2145274886 cites W2325038063 @default.
• W2145274886 cites W2329901969 @default.
• W2145274886 cites W39285734 @default.
• W2145274886 cites W4229932900 @default.
• W2145274886 cites W4245762884 @default.
• W2145274886 doi "https://doi.org/10.1371/journal.pone.0027875" @default.
• W2145274886 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3222659" @default.
• W2145274886 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22132157" @default.
• W2145274886 hasPublicationYear "2011" @default.
• W2145274886 type Work @default.
• W2145274886 sameAs 2145274886 @default.
• W2145274886 citedByCount "36" @default.
• W2145274886 countsByYear W21452748862012 @default.
• W2145274886 countsByYear W21452748862013 @default.
• W2145274886 countsByYear W21452748862014 @default.
• W2145274886 countsByYear W21452748862015 @default.
• W2145274886 countsByYear W21452748862016 @default.
• W2145274886 countsByYear W21452748862017 @default.
• W2145274886 countsByYear W21452748862018 @default.
• W2145274886 countsByYear W21452748862019 @default.
• W2145274886 countsByYear W21452748862020 @default.
• W2145274886 countsByYear W21452748862021 @default.
• W2145274886 countsByYear W21452748862023 @default.
• W2145274886 crossrefType "journal-article" @default.
• W2145274886 hasAuthorship W2145274886A5004326476 @default.
• W2145274886 hasAuthorship W2145274886A5031949605 @default.
• W2145274886 hasAuthorship W2145274886A5038260780 @default.
• W2145274886 hasAuthorship W2145274886A5043712906 @default.
• W2145274886 hasAuthorship W2145274886A5044729242 @default.
• W2145274886 hasAuthorship W2145274886A5067334052 @default.
• W2145274886 hasAuthorship W2145274886A5079922285 @default.
• W2145274886 hasAuthorship W2145274886A5085571373 @default.
• W2145274886 hasBestOaLocation W21452748861 @default.
• W2145274886 hasConcept C126322002 @default.
• W2145274886 hasConcept C170493617 @default.
• W2145274886 hasConcept C203014093 @default.
• W2145274886 hasConcept C2776246183 @default.

• next