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- W2145278370 abstract "Recurrent gangrenous leg ulcers were associated with a monoclonal IgGk cryoglobulinaemia, though without overt myeloma. Cryoprecipitation of the serum in vitro gave a reversible gel with microtubular structure, built from the monomer and with a high degree of order. The same structure was found distending the superficial vessels of the ulcer biopsy, as well as extravascularly. There was no vasculitis, and luminal obstruction appeared responsible for the ulceration. Microtubular structures occur in nature among diverse proteins and viruses. The protein studied here is similar to a reported instance of myeloma cryo-IgGk." @default.
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- W2145278370 date "1976-09-01" @default.
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- W2145278370 title "Cryoimmunoglobulin IgGk with microtubular ultrastructure associated with pyoderma gangrenosum" @default.
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- W2145278370 doi "https://doi.org/10.1002/path.1711200104" @default.
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