Matches in SemOpenAlex for { <https://semopenalex.org/work/W2145287030> ?p ?o ?g. }
- W2145287030 endingPage "502" @default.
- W2145287030 startingPage "495" @default.
- W2145287030 abstract "All-trans retinoic acid (ATRA) treatment causes CAOV3 ovarian carcinoma cells to growth arrest in the G0/G1 phase and to elevate the level of Rb2/p130 protein. PP2A, a serine/threonine phosphatase, binds and dephosphorylates Rb2/p130, thereby increasing the half-life of Rb2/p130 in the cell. In order to further characterize the interaction between Rb2/p130 and PP2A upon ATRA treatment, we examined the posttranslational modification of PP2A. ATRA treatment leads to hypophosphorylation of PP2A catalytic subunit (PP2Ac) that correlates with increased PP2A activity. In addition, the N-terminus of PP2Ac binds directly to NLS sequences located in the C-terminus of Rb2/p130. Furthermore, CAOV3 cells transfected with a truncated Rb2/p130 construct consisting of only the wt C-terminus grew more aggressively and were less sensitive to ATRA treatment when compared to parental CAOV3 cells. In contrast, CAOV3 cells transfected with a truncated Rb2/p130 construct consisting of only the C-terminus in which the NLS sites were mutated and which could not interact with PP2A, were as sensitive to ATRA treatment as parental CAOV3 cells. These studies suggest that ATRA treatment suppresses the growth of CAOV3 cells via a novel posttranscriptional mechanism involving PP2A." @default.
- W2145287030 created "2016-06-24" @default.
- W2145287030 creator A5012012199 @default.
- W2145287030 creator A5024798356 @default.
- W2145287030 creator A5037340003 @default.
- W2145287030 creator A5059484191 @default.
- W2145287030 date "2005-10-04" @default.
- W2145287030 modified "2023-09-30" @default.
- W2145287030 title "Interaction of PP2A catalytic subunit with Rb2/p130 is required for all-trans retinoic acid suppression of ovarian carcinoma cell growth" @default.
- W2145287030 cites W1499540451 @default.
- W2145287030 cites W1503356528 @default.
- W2145287030 cites W1775327385 @default.
- W2145287030 cites W1795525374 @default.
- W2145287030 cites W1892570697 @default.
- W2145287030 cites W1928368896 @default.
- W2145287030 cites W1964595176 @default.
- W2145287030 cites W1968157723 @default.
- W2145287030 cites W1969173610 @default.
- W2145287030 cites W1974923921 @default.
- W2145287030 cites W1976313499 @default.
- W2145287030 cites W1990409176 @default.
- W2145287030 cites W1993465569 @default.
- W2145287030 cites W1997664222 @default.
- W2145287030 cites W2000555456 @default.
- W2145287030 cites W2001699038 @default.
- W2145287030 cites W2022664595 @default.
- W2145287030 cites W2026106245 @default.
- W2145287030 cites W2028642327 @default.
- W2145287030 cites W2028746615 @default.
- W2145287030 cites W2031146595 @default.
- W2145287030 cites W2031285921 @default.
- W2145287030 cites W2032966848 @default.
- W2145287030 cites W2044446216 @default.
- W2145287030 cites W2057221801 @default.
- W2145287030 cites W2060450178 @default.
- W2145287030 cites W2063522301 @default.
- W2145287030 cites W2070526601 @default.
- W2145287030 cites W2074311666 @default.
- W2145287030 cites W2079523306 @default.
- W2145287030 cites W2080612628 @default.
- W2145287030 cites W2087220115 @default.
- W2145287030 cites W2092121558 @default.
- W2145287030 cites W2100861348 @default.
- W2145287030 cites W2101803513 @default.
- W2145287030 cites W2102088076 @default.
- W2145287030 cites W2104338484 @default.
- W2145287030 cites W2109651348 @default.
- W2145287030 cites W2125905076 @default.
- W2145287030 cites W2137221055 @default.
- W2145287030 cites W2137653823 @default.
- W2145287030 cites W2158212151 @default.
- W2145287030 cites W2160478917 @default.
- W2145287030 cites W2312700083 @default.
- W2145287030 cites W2339318589 @default.
- W2145287030 cites W3023305311 @default.
- W2145287030 cites W4240253200 @default.
- W2145287030 cites W4241770029 @default.
- W2145287030 cites W969782540 @default.
- W2145287030 doi "https://doi.org/10.1002/jcp.20490" @default.
- W2145287030 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16206244" @default.
- W2145287030 hasPublicationYear "2005" @default.
- W2145287030 type Work @default.
- W2145287030 sameAs 2145287030 @default.
- W2145287030 citedByCount "23" @default.
- W2145287030 countsByYear W21452870302012 @default.
- W2145287030 countsByYear W21452870302013 @default.
- W2145287030 countsByYear W21452870302014 @default.
- W2145287030 countsByYear W21452870302018 @default.
- W2145287030 crossrefType "journal-article" @default.
- W2145287030 hasAuthorship W2145287030A5012012199 @default.
- W2145287030 hasAuthorship W2145287030A5024798356 @default.
- W2145287030 hasAuthorship W2145287030A5037340003 @default.
- W2145287030 hasAuthorship W2145287030A5059484191 @default.
- W2145287030 hasConcept C104292427 @default.
- W2145287030 hasConcept C104317684 @default.
- W2145287030 hasConcept C11960822 @default.
- W2145287030 hasConcept C153911025 @default.
- W2145287030 hasConcept C178666793 @default.
- W2145287030 hasConcept C185592680 @default.
- W2145287030 hasConcept C2776414213 @default.
- W2145287030 hasConcept C2781121885 @default.
- W2145287030 hasConcept C389152 @default.
- W2145287030 hasConcept C54009773 @default.
- W2145287030 hasConcept C55493867 @default.
- W2145287030 hasConcept C86803240 @default.
- W2145287030 hasConcept C95444343 @default.
- W2145287030 hasConceptScore W2145287030C104292427 @default.
- W2145287030 hasConceptScore W2145287030C104317684 @default.
- W2145287030 hasConceptScore W2145287030C11960822 @default.
- W2145287030 hasConceptScore W2145287030C153911025 @default.
- W2145287030 hasConceptScore W2145287030C178666793 @default.
- W2145287030 hasConceptScore W2145287030C185592680 @default.
- W2145287030 hasConceptScore W2145287030C2776414213 @default.
- W2145287030 hasConceptScore W2145287030C2781121885 @default.
- W2145287030 hasConceptScore W2145287030C389152 @default.
- W2145287030 hasConceptScore W2145287030C54009773 @default.
- W2145287030 hasConceptScore W2145287030C55493867 @default.
- W2145287030 hasConceptScore W2145287030C86803240 @default.