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- W2145297943 abstract "<b><i>Purpose:</i></b> To investigate the association between the laterality of diagnostic prostate cancer-positive biopsy cores and definitive tumor stage on final pathology (organ-confined versus non-organ-confined). <b><i>Patients and Methods:</i></b> This is a retrospective analysis of 165 men after radical prostatectomy fulfilling our active surveillance criteria at the time of surgery. Nominal variables were compared using Fisher's exact test, continuous variables using Mann-Whitney test. Odds ratios including 95% Wald and probabilities including 95% Wilson confidence intervals are provided. <b><i>Results:</i></b> 5 (3%) patients had non-organ-confined disease: 2 out of 144 (1%) patients with unilateral and 3 out of 17 (18%) patients with bilateral cancer-positive biopsy cores (p = 0.009). The estimated odds ratio for non-organ-confined disease was 14.67 (95% confidence interval 1.55-189.23) for patients with bilateral compared to patients with unilateral cancer-positive biopsy cores. The sensitivity, specificity and accuracy of bilaterally positive biopsies as an additional criterion to identify non-organ-confined disease are 60, 91 and 90%, respectively. <b><i>Conclusion:</i></b> In our cohort, patients with bilaterally positive biopsy cores were significantly more likely to harbor a non-organ-confined tumor than patients with unilaterally positive cores. Due to their high specificity, bilaterally positive biopsies may represent a reasonable exclusion criterion for active surveillance if our results are corroborated in further studies." @default.
- W2145297943 created "2016-06-24" @default.
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- W2145297943 date "2014-01-01" @default.
- W2145297943 modified "2023-10-10" @default.
- W2145297943 title "Bilaterally Positive Biopsy Cores Are Associated with Non-Organ-Confined Disease in Prostate Cancer Patients Eligible for Active Surveillance" @default.
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- W2145297943 doi "https://doi.org/10.1159/000357121" @default.
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