Matches in SemOpenAlex for { <https://semopenalex.org/work/W2145301834> ?p ?o ?g. }
- W2145301834 endingPage "320" @default.
- W2145301834 startingPage "311" @default.
- W2145301834 abstract "ADA (alteration/deficiency in activation) 3 is a conserved component of several transcriptional adaptor and HAT (histone acetyltransferase) complexes that regulate RNA polymerase II-mediated gene expression. Within the HAT complexes ADA3 is associated with ADA2 and the HAT GCN5 (general control non-repressed 5). ADA3 plays roles in diverse cellular processes and also in malignancies by modulating GCN5 catalytic activity and/or by interactions with other regulators. To gain a better understanding of ADA3 function, we used a yeast two-hybrid approach to screen a human fetal cDNA library for proteins that interacted with hADA3 (human ADA3). We identified three novel hADA3-interacting partners, a transcriptional regulator, AATF (apoptosis-antagonizing transcription factor), and regulatory subunits of the PP1 (protein phosphatase 1) and PP2A (protein phosphatase 2A) [PPP1R7 (PP1 regulatory subunit 7) and PPP2R5D (PP2A 56 kDa regulatory subunit δ isoform) respectively]. Analysis of truncated versions of hADA3 indicated that the C-terminal ADA2-interacting domain was not required for these interactions. Fluorescent microscopy analysis and co-immunoprecipitation provided support for the co-localization and interaction of hADA3 with these proteins in human cells. Expression of the interacting proteins altered expression of an hADA3-regulated reporter gene, suggesting functional consequences for the interactions. The detected interactions of hADA3 might extend the spectrum of mechanisms by which ADA3 can contribute to the regulation of gene expression and shed light on processes mediated by these newly identified ADA3 partners." @default.
- W2145301834 created "2016-06-24" @default.
- W2145301834 creator A5003721123 @default.
- W2145301834 creator A5041490644 @default.
- W2145301834 creator A5042758317 @default.
- W2145301834 creator A5049859810 @default.
- W2145301834 creator A5084060158 @default.
- W2145301834 creator A5089899171 @default.
- W2145301834 date "2013-02-15" @default.
- W2145301834 modified "2023-09-27" @default.
- W2145301834 title "Identification of transcriptional and phosphatase regulators as interaction partners of human ADA3, a component of histone acetyltransferase complexes" @default.
- W2145301834 cites W144635628 @default.
- W2145301834 cites W1735187387 @default.
- W2145301834 cites W1763859619 @default.
- W2145301834 cites W1977186059 @default.
- W2145301834 cites W1981922164 @default.
- W2145301834 cites W1989439152 @default.
- W2145301834 cites W1992902970 @default.
- W2145301834 cites W2002051035 @default.
- W2145301834 cites W2008620377 @default.
- W2145301834 cites W2013890168 @default.
- W2145301834 cites W2014567183 @default.
- W2145301834 cites W2019087484 @default.
- W2145301834 cites W2019339797 @default.
- W2145301834 cites W2021352276 @default.
- W2145301834 cites W2025037657 @default.
- W2145301834 cites W2027396500 @default.
- W2145301834 cites W2027881996 @default.
- W2145301834 cites W2034647409 @default.
- W2145301834 cites W2049487120 @default.
- W2145301834 cites W2055476265 @default.
- W2145301834 cites W2055666215 @default.
- W2145301834 cites W2058756071 @default.
- W2145301834 cites W2062865836 @default.
- W2145301834 cites W2065231473 @default.
- W2145301834 cites W2066305078 @default.
- W2145301834 cites W2067914318 @default.
- W2145301834 cites W2072919225 @default.
- W2145301834 cites W2077026916 @default.
- W2145301834 cites W2077389876 @default.
- W2145301834 cites W2080950295 @default.
- W2145301834 cites W2088332201 @default.
- W2145301834 cites W2090997831 @default.
- W2145301834 cites W2091016107 @default.
- W2145301834 cites W2093451491 @default.
- W2145301834 cites W2095669369 @default.
- W2145301834 cites W2097751554 @default.
- W2145301834 cites W2098760158 @default.
- W2145301834 cites W2111578933 @default.
- W2145301834 cites W2112369696 @default.
- W2145301834 cites W2117316674 @default.
- W2145301834 cites W2126189696 @default.
- W2145301834 cites W2133452708 @default.
- W2145301834 cites W2140676509 @default.
- W2145301834 cites W2140985183 @default.
- W2145301834 cites W2143686770 @default.
- W2145301834 cites W2144147476 @default.
- W2145301834 cites W2145843510 @default.
- W2145301834 cites W2146724295 @default.
- W2145301834 cites W2148649353 @default.
- W2145301834 cites W2166609325 @default.
- W2145301834 cites W2168012760 @default.
- W2145301834 cites W2489855301 @default.
- W2145301834 doi "https://doi.org/10.1042/bj20120452" @default.
- W2145301834 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23167988" @default.
- W2145301834 hasPublicationYear "2013" @default.
- W2145301834 type Work @default.
- W2145301834 sameAs 2145301834 @default.
- W2145301834 citedByCount "9" @default.
- W2145301834 countsByYear W21453018342013 @default.
- W2145301834 countsByYear W21453018342015 @default.
- W2145301834 countsByYear W21453018342016 @default.
- W2145301834 countsByYear W21453018342017 @default.
- W2145301834 countsByYear W21453018342020 @default.
- W2145301834 crossrefType "journal-article" @default.
- W2145301834 hasAuthorship W2145301834A5003721123 @default.
- W2145301834 hasAuthorship W2145301834A5041490644 @default.
- W2145301834 hasAuthorship W2145301834A5042758317 @default.
- W2145301834 hasAuthorship W2145301834A5049859810 @default.
- W2145301834 hasAuthorship W2145301834A5084060158 @default.
- W2145301834 hasAuthorship W2145301834A5089899171 @default.
- W2145301834 hasConcept C101762097 @default.
- W2145301834 hasConcept C104292427 @default.
- W2145301834 hasConcept C104317684 @default.
- W2145301834 hasConcept C11960822 @default.
- W2145301834 hasConcept C150194340 @default.
- W2145301834 hasConcept C165864922 @default.
- W2145301834 hasConcept C178666793 @default.
- W2145301834 hasConcept C27153228 @default.
- W2145301834 hasConcept C2778001298 @default.
- W2145301834 hasConcept C389152 @default.
- W2145301834 hasConcept C54355233 @default.
- W2145301834 hasConcept C64350747 @default.
- W2145301834 hasConcept C71829478 @default.
- W2145301834 hasConcept C86339819 @default.
- W2145301834 hasConcept C86803240 @default.
- W2145301834 hasConcept C95444343 @default.
- W2145301834 hasConceptScore W2145301834C101762097 @default.