FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2145302904> ?p ?o ?g. }

• W2145302904 endingPage "302" @default.
• W2145302904 startingPage "296" @default.
• W2145302904 abstract "With the recent epizootic of bovine spongiform encephalopathy in Europe, the differential diagnosis of neuronal vacuolation and spongiform change in other species has become critically important. Four Rottweiler puppies of both sexes, presented at 3-8 months of age, had clinical signs of generalized weakness and ataxia that started at 6 weeks of age. In all pups, neurologic examination detected an ataxia and tetraparesis, most severe in the pelvic limbs, and slowed proprioceptive placing reactions. Subsequently, there was rapid progressive neurologic deterioration, with severe placing deficits, knuckling, severe ataxia, and quadraparesis by 8 months of age. At necropsy, no gross lesions were observed. Microscopic lesions were restricted to the nervous system. The major lesion in all dogs was an intracytoplasmic neuronal vacuolation that was most prominent in the cerebellar roof nuclei and in nuclei of the extrapyramidal system. Similar vacuolation was found in neurons in both dorsal nerve root ganglia, myenteric plexus, and other ganglia of the autonomic nervous system. The single or multiple empty vacuoles were between 1 and 45 μm in diameter. A mild spongiform change was seen in the adjacent neuropil. Purkinje cell vacuolation and degeneration with segmental cell loss was seen in the oldest dog. In ventromedial and dorsolateral areas of the spinal cord white matter, there was mild bilaterally symmetrical axonal degeneration. Immunoblotting and immunocytochemical staining of the brain for protease-resistant scrapie prion protein was negative. All forms of vacuoles were negative for immunohistochemical staining with a variety of lectins. Ultrastructurally, the vacuoles were bound by a single membrane and contained granular material and sometimes membranous profiles. There was mild distension of the cytocavitary network but no unequivocal connection with the vacuoles was found. Axosomatic and axodendritic synapses in affected neurons were intact both ultrastructurally and with synaptophysin immunostaining. The clinicopathologic findings were different from those seen in the other neurologic diseases of Rottweilers. The age of the dogs, distribution and type of the lesions, ultrastructural findings, and negative immunoblotting most likely rule out the possibility of a scrapie agent-associated spongiform encephalopathy. However, the etiology of this new disease was not determined." @default.
• W2145302904 created "2016-06-24" @default.
• W2145302904 creator A5016608854 @default.
• W2145302904 creator A5016783227 @default.
• W2145302904 creator A5021621807 @default.
• W2145302904 creator A5050717124 @default.
• W2145302904 creator A5058198523 @default.
• W2145302904 creator A5061462661 @default.
• W2145302904 creator A5065669185 @default.
• W2145302904 date "1997-07-01" @default.
• W2145302904 modified "2023-09-26" @default.
• W2145302904 title "Neuronal Vacuolation and Spinocerebellar Degeneration in Young Rottweiler Dogs" @default.
• W2145302904 cites W1903523394 @default.
• W2145302904 cites W1984232007 @default.
• W2145302904 cites W1987526595 @default.
• W2145302904 cites W1992777459 @default.
• W2145302904 cites W1999758548 @default.
• W2145302904 cites W2008575992 @default.
• W2145302904 cites W2013997496 @default.
• W2145302904 cites W2014065311 @default.
• W2145302904 cites W2025425293 @default.
• W2145302904 cites W2027536719 @default.
• W2145302904 cites W2037236304 @default.
• W2145302904 cites W2039877615 @default.
• W2145302904 cites W2040609276 @default.
• W2145302904 cites W2045121639 @default.
• W2145302904 cites W2052091508 @default.
• W2145302904 cites W2053229141 @default.
• W2145302904 cites W2056158685 @default.
• W2145302904 cites W2058669441 @default.
• W2145302904 cites W2083061760 @default.
• W2145302904 cites W2089981722 @default.
• W2145302904 cites W2111154464 @default.
• W2145302904 cites W2119490596 @default.
• W2145302904 cites W2184353599 @default.
• W2145302904 cites W2318643717 @default.
• W2145302904 cites W2335105728 @default.
• W2145302904 cites W2464625520 @default.
• W2145302904 cites W2885420822 @default.
• W2145302904 cites W2918535922 @default.
• W2145302904 doi "https://doi.org/10.1177/030098589703400405" @default.
• W2145302904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9240838" @default.
• W2145302904 hasPublicationYear "1997" @default.
• W2145302904 type Work @default.
• W2145302904 sameAs 2145302904 @default.
• W2145302904 citedByCount "52" @default.
• W2145302904 countsByYear W21453029042012 @default.
• W2145302904 countsByYear W21453029042013 @default.
• W2145302904 countsByYear W21453029042016 @default.
• W2145302904 countsByYear W21453029042017 @default.
• W2145302904 countsByYear W21453029042018 @default.
• W2145302904 countsByYear W21453029042019 @default.
• W2145302904 countsByYear W21453029042020 @default.
• W2145302904 countsByYear W21453029042021 @default.
• W2145302904 countsByYear W21453029042023 @default.
• W2145302904 crossrefType "journal-article" @default.
• W2145302904 hasAuthorship W2145302904A5016608854 @default.
• W2145302904 hasAuthorship W2145302904A5016783227 @default.
• W2145302904 hasAuthorship W2145302904A5021621807 @default.
• W2145302904 hasAuthorship W2145302904A5050717124 @default.
• W2145302904 hasAuthorship W2145302904A5058198523 @default.
• W2145302904 hasAuthorship W2145302904A5061462661 @default.
• W2145302904 hasAuthorship W2145302904A5065669185 @default.
• W2145302904 hasConcept C105702510 @default.
• W2145302904 hasConcept C126838900 @default.
• W2145302904 hasConcept C142724271 @default.
• W2145302904 hasConcept C143409427 @default.
• W2145302904 hasConcept C169760540 @default.
• W2145302904 hasConcept C2777831001 @default.
• W2145302904 hasConcept C2778013878 @default.
• W2145302904 hasConcept C2780775167 @default.
• W2145302904 hasConcept C2780906641 @default.
• W2145302904 hasConcept C2781192897 @default.
• W2145302904 hasConcept C529278444 @default.
• W2145302904 hasConcept C71924100 @default.
• W2145302904 hasConcept C86803240 @default.
• W2145302904 hasConceptScore W2145302904C105702510 @default.
• W2145302904 hasConceptScore W2145302904C126838900 @default.
• W2145302904 hasConceptScore W2145302904C142724271 @default.
• W2145302904 hasConceptScore W2145302904C143409427 @default.
• W2145302904 hasConceptScore W2145302904C169760540 @default.
• W2145302904 hasConceptScore W2145302904C2777831001 @default.
• W2145302904 hasConceptScore W2145302904C2778013878 @default.
• W2145302904 hasConceptScore W2145302904C2780775167 @default.
• W2145302904 hasConceptScore W2145302904C2780906641 @default.
• W2145302904 hasConceptScore W2145302904C2781192897 @default.
• W2145302904 hasConceptScore W2145302904C529278444 @default.
• W2145302904 hasConceptScore W2145302904C71924100 @default.
• W2145302904 hasConceptScore W2145302904C86803240 @default.
• W2145302904 hasIssue "4" @default.
• W2145302904 hasLocation W21453029041 @default.
• W2145302904 hasLocation W21453029042 @default.
• W2145302904 hasOpenAccess W2145302904 @default.
• W2145302904 hasPrimaryLocation W21453029041 @default.
• W2145302904 hasRelatedWork W1972096993 @default.
• W2145302904 hasRelatedWork W2085481292 @default.
• W2145302904 hasRelatedWork W2096406678 @default.
• W2145302904 hasRelatedWork W2106181955 @default.

• next