FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2145308220> ?p ?o ?g. }

• W2145308220 endingPage "1200" @default.
• W2145308220 startingPage "1192" @default.
• W2145308220 abstract "ABSTRACT Combinations of reverse transcriptase (RT) inhibitors are currently used in anti-human immunodeficiency virus therapy in order to prevent or delay the emergence of resistant virus and to improve the efficacy against viral enzymes carrying resistance mutations. Drug-drug interactions can result in either positive (additive or synergistic inhibition) or adverse (antagonistic interaction, synergistic toxicity) effects. Elucidation of the nature of drug interaction would help to rationalize the choice of antiretroviral agents to be used in combination. In this study, different combinations of nucleoside and nonnucleoside inhibitors, including d - and l -(β)-deoxy- and -dideoxynucleoside triphosphate analogues, have been tested in in vitro RT assays against either recombinant wild-type RT or RT bearing clinically relevant nonnucleoside inhibitor resistance mutations (L100I, K103N, Y181I), and the nature of the interaction (either synergistic or antagonistic) of these associations was evaluated. The results showed that (i) synergy of a combination was not always equally influenced by the individual agents utilized, (ii) a synergistic combination could improve the sensitivity profile of a drug-resistant mutant enzyme to the single agents utilized, (iii) l -(β)-enantiomers of nucleoside RT inhibitors were synergistic when combined with nonnucleoside RT inhibitors, and (iv) inter- and intracombination comparisons of the relative potencies of each drug could be used to highlight the different contributions of each drug to the observed synergy." @default.
• W2145308220 created "2016-06-24" @default.
• W2145308220 creator A5002029611 @default.
• W2145308220 creator A5047462853 @default.
• W2145308220 creator A5068311291 @default.
• W2145308220 creator A5077133338 @default.
• W2145308220 creator A5088526551 @default.
• W2145308220 creator A5090204935 @default.
• W2145308220 date "2001-04-01" @default.
• W2145308220 modified "2023-09-25" @default.
• W2145308220 title "Potentiation of Inhibition of Wild-Type and Mutant Human Immunodeficiency Virus Type 1 Reverse Transcriptases by Combinations of Nonnucleoside Inhibitors and<scp>d</scp>- and<scp>l</scp>-(β)-Dideoxynucleoside Triphosphate Analogs" @default.
• W2145308220 cites W1493703283 @default.
• W2145308220 cites W1536132113 @default.
• W2145308220 cites W1967785113 @default.
• W2145308220 cites W1986003021 @default.
• W2145308220 cites W1988861859 @default.
• W2145308220 cites W1994707005 @default.
• W2145308220 cites W2011528327 @default.
• W2145308220 cites W2025301291 @default.
• W2145308220 cites W2028522999 @default.
• W2145308220 cites W2038810478 @default.
• W2145308220 cites W2053372203 @default.
• W2145308220 cites W2059164290 @default.
• W2145308220 cites W2063785972 @default.
• W2145308220 cites W2065036966 @default.
• W2145308220 cites W2076284523 @default.
• W2145308220 cites W2077248050 @default.
• W2145308220 cites W2090810359 @default.
• W2145308220 cites W2090833396 @default.
• W2145308220 cites W2093110849 @default.
• W2145308220 cites W2100182084 @default.
• W2145308220 cites W2112191861 @default.
• W2145308220 cites W2123415620 @default.
• W2145308220 cites W2133759520 @default.
• W2145308220 cites W2161558889 @default.
• W2145308220 cites W2166079348 @default.
• W2145308220 cites W2166667597 @default.
• W2145308220 cites W2167716173 @default.
• W2145308220 cites W2169635828 @default.
• W2145308220 cites W2223501982 @default.
• W2145308220 cites W2321852728 @default.
• W2145308220 cites W2409392632 @default.
• W2145308220 cites W2417309096 @default.
• W2145308220 cites W2417505168 @default.
• W2145308220 cites W2418775551 @default.
• W2145308220 cites W2437191410 @default.
• W2145308220 doi "https://doi.org/10.1128/aac.45.4.1192-1200.2001" @default.
• W2145308220 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/90443" @default.
• W2145308220 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11257034" @default.
• W2145308220 hasPublicationYear "2001" @default.
• W2145308220 type Work @default.
• W2145308220 sameAs 2145308220 @default.
• W2145308220 citedByCount "11" @default.
• W2145308220 countsByYear W21453082202012 @default.
• W2145308220 countsByYear W21453082202013 @default.
• W2145308220 countsByYear W21453082202014 @default.
• W2145308220 countsByYear W21453082202018 @default.
• W2145308220 crossrefType "journal-article" @default.
• W2145308220 hasAuthorship W2145308220A5002029611 @default.
• W2145308220 hasAuthorship W2145308220A5047462853 @default.
• W2145308220 hasAuthorship W2145308220A5068311291 @default.
• W2145308220 hasAuthorship W2145308220A5077133338 @default.
• W2145308220 hasAuthorship W2145308220A5088526551 @default.
• W2145308220 hasAuthorship W2145308220A5090204935 @default.
• W2145308220 hasBestOaLocation W21453082201 @default.
• W2145308220 hasConcept C104317684 @default.
• W2145308220 hasConcept C114851261 @default.
• W2145308220 hasConcept C143065580 @default.
• W2145308220 hasConcept C156719811 @default.
• W2145308220 hasConcept C159047783 @default.
• W2145308220 hasConcept C185592680 @default.
• W2145308220 hasConcept C207001950 @default.
• W2145308220 hasConcept C207583985 @default.
• W2145308220 hasConcept C2522874641 @default.
• W2145308220 hasConcept C2776543447 @default.
• W2145308220 hasConcept C2777351918 @default.
• W2145308220 hasConcept C2780035454 @default.
• W2145308220 hasConcept C54355233 @default.
• W2145308220 hasConcept C55493867 @default.
• W2145308220 hasConcept C67705224 @default.
• W2145308220 hasConcept C86803240 @default.
• W2145308220 hasConcept C89423630 @default.
• W2145308220 hasConcept C98274493 @default.
• W2145308220 hasConceptScore W2145308220C104317684 @default.
• W2145308220 hasConceptScore W2145308220C114851261 @default.
• W2145308220 hasConceptScore W2145308220C143065580 @default.
• W2145308220 hasConceptScore W2145308220C156719811 @default.
• W2145308220 hasConceptScore W2145308220C159047783 @default.
• W2145308220 hasConceptScore W2145308220C185592680 @default.
• W2145308220 hasConceptScore W2145308220C207001950 @default.
• W2145308220 hasConceptScore W2145308220C207583985 @default.
• W2145308220 hasConceptScore W2145308220C2522874641 @default.
• W2145308220 hasConceptScore W2145308220C2776543447 @default.
• W2145308220 hasConceptScore W2145308220C2777351918 @default.
• W2145308220 hasConceptScore W2145308220C2780035454 @default.
• W2145308220 hasConceptScore W2145308220C54355233 @default.
• W2145308220 hasConceptScore W2145308220C55493867 @default.
• W2145308220 hasConceptScore W2145308220C67705224 @default.

• next