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• W2145320791 endingPage "1080" @default.
• W2145320791 startingPage "1074" @default.
• W2145320791 abstract "A novel method for immobilization of acetylcholinesterase (AChE) by binding covalently to a cross-linked chitosan-multiwall carbon nanotube (MWNT) composite is described. In addition a sensitive, fast, cheap and automatizable flow injection detection of an organophosphorous insecticide was developed. The MWNTs were homogeneously distributed in the chitosan membrane which showed a homogeneous porous structure. The immobilized AChE could catalyze the hydrolysis of acetylthiocholine with a K(M)app value of 177 microM to form thiocholine, which was then oxidized to produce detectable signal in a linear range of 1.0-500 microM and fast response. MWNTs could catalyze the electrooxidation of thiocholine, thus increasing detection sensitivity. Based on the inhibition of an organophosphorous insecticide on the enzymatic activity of AChE, using Sulfotep as a model compound, the conditions for the flow-injection detection of the insecticide were optimized. Both biocompatibility of chitosan and inherent conductive properties of MWNTs favored the detection of the insecticide from 1.5 to 80 microM along with good stability and reproducibility. 95 % reactivation from inhibited AChE could be regenerated by using 2-pyridinealdoxime methiodide within 15 min for 15 times. The detection of Sulfotep samples exhibited satisfactory results. The proposed flow-injection analysis device can be applied to automated determination and characterization of enzyme inhibitors." @default.
• W2145320791 created "2016-06-24" @default.
• W2145320791 creator A5017375525 @default.
• W2145320791 creator A5047919502 @default.
• W2145320791 date "2006-01-23" @default.
• W2145320791 modified "2023-10-14" @default.
• W2145320791 title "Binding of Acetylcholinesterase to Multiwall Carbon Nanotube-Cross-Linked Chitosan Composite for Flow-Injection Amperometric Detection of an Organophosphorous Insecticide" @default.
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• W2145320791 doi "https://doi.org/10.1002/chem.200500178" @default.
• W2145320791 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16240314" @default.
• W2145320791 hasPublicationYear "2006" @default.
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