FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2145338511> ?p ?o ?g. }

• W2145338511 endingPage "1053" @default.
• W2145338511 startingPage "1043" @default.
• W2145338511 abstract "PCDH10 has been implicated as a tumor suppressor, since epigenetic alterations of this gene have been noted in multiple tumor types. However, to date, studies regarding its role in acute and chronic leukemias are lacking. Here, we have investigated the presence of promoter hypermethylation of two CpG islands of the PCDH10 gene by methylation-specific PCR in 215 cases of various subsets of myeloid- and lymphoid-lineage leukemias. We found that PCDH10 promoter hypermethylation was frequent in both B-cell (81.9%) and T-cell (80%) acute lymphoblastic leukemia (ALL), while it was present in low frequency in most subtypes of myeloid leukemias (25.9%) and rare in chronic myeloid leukemia (2.2%). PCDH10 expression was downregulated via promoter hypermethylation in primary ALL samples (N = 4) and leukemia cell lines (N = 11). The transcriptional repression caused by PCDH10 methylation could be restored by pharmacologic inhibition of DNA methyltransferases. ALL cell lines harboring methylation-mediated inactivation of PCDH10 were less sensitive to commonly used leukemia-specific drugs suggesting that PCDH10 methylation might serve as a biomarker of chemotherapy response. Our results demonstrate that PCDH10 is a target of epigenetic silencing in ALL, a phenomenon that may impact lymphoid-lineage leukemogenesis, serve as an indicator of drug resistance and may also have potential implications for targeted epigenetic therapy. © 2011 Wiley Periodicals, Inc." @default.
• W2145338511 created "2016-06-24" @default.
• W2145338511 creator A5000186073 @default.
• W2145338511 creator A5001580481 @default.
• W2145338511 creator A5001619276 @default.
• W2145338511 creator A5002615131 @default.
• W2145338511 creator A5014966517 @default.
• W2145338511 creator A5028125302 @default.
• W2145338511 creator A5040458965 @default.
• W2145338511 creator A5048733835 @default.
• W2145338511 creator A5055088974 @default.
• W2145338511 creator A5056767216 @default.
• W2145338511 creator A5062490222 @default.
• W2145338511 creator A5069512485 @default.
• W2145338511 creator A5073892799 @default.
• W2145338511 creator A5087160650 @default.
• W2145338511 creator A5091159415 @default.
• W2145338511 date "2011-08-24" @default.
• W2145338511 modified "2023-10-16" @default.
• W2145338511 title "Promoter methylation-mediated inactivation of PCDH10 in acute lymphoblastic leukemia contributes to chemotherapy resistance" @default.
• W2145338511 cites W1964212105 @default.
• W2145338511 cites W1977380325 @default.
• W2145338511 cites W1987446594 @default.
• W2145338511 cites W2003256314 @default.
• W2145338511 cites W2010736881 @default.
• W2145338511 cites W2026119866 @default.
• W2145338511 cites W2035576418 @default.
• W2145338511 cites W2035990896 @default.
• W2145338511 cites W2044499590 @default.
• W2145338511 cites W2055294254 @default.
• W2145338511 cites W2070685259 @default.
• W2145338511 cites W2076930715 @default.
• W2145338511 cites W2082592723 @default.
• W2145338511 cites W2084021611 @default.
• W2145338511 cites W2085453248 @default.
• W2145338511 cites W2085819466 @default.
• W2145338511 cites W2093640345 @default.
• W2145338511 cites W2109880498 @default.
• W2145338511 cites W2134288198 @default.
• W2145338511 cites W2167228936 @default.
• W2145338511 cites W2169550012 @default.
• W2145338511 cites W2170222791 @default.
• W2145338511 cites W4230231903 @default.
• W2145338511 cites W4243761960 @default.
• W2145338511 doi "https://doi.org/10.1002/gcc.20922" @default.
• W2145338511 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21960365" @default.
• W2145338511 hasPublicationYear "2011" @default.
• W2145338511 type Work @default.
• W2145338511 sameAs 2145338511 @default.
• W2145338511 citedByCount "28" @default.
• W2145338511 countsByYear W21453385112012 @default.
• W2145338511 countsByYear W21453385112013 @default.
• W2145338511 countsByYear W21453385112014 @default.
• W2145338511 countsByYear W21453385112015 @default.
• W2145338511 countsByYear W21453385112016 @default.
• W2145338511 countsByYear W21453385112017 @default.
• W2145338511 countsByYear W21453385112018 @default.
• W2145338511 countsByYear W21453385112020 @default.
• W2145338511 countsByYear W21453385112021 @default.
• W2145338511 countsByYear W21453385112022 @default.
• W2145338511 crossrefType "journal-article" @default.
• W2145338511 hasAuthorship W2145338511A5000186073 @default.
• W2145338511 hasAuthorship W2145338511A5001580481 @default.
• W2145338511 hasAuthorship W2145338511A5001619276 @default.
• W2145338511 hasAuthorship W2145338511A5002615131 @default.
• W2145338511 hasAuthorship W2145338511A5014966517 @default.
• W2145338511 hasAuthorship W2145338511A5028125302 @default.
• W2145338511 hasAuthorship W2145338511A5040458965 @default.
• W2145338511 hasAuthorship W2145338511A5048733835 @default.
• W2145338511 hasAuthorship W2145338511A5055088974 @default.
• W2145338511 hasAuthorship W2145338511A5056767216 @default.
• W2145338511 hasAuthorship W2145338511A5062490222 @default.
• W2145338511 hasAuthorship W2145338511A5069512485 @default.
• W2145338511 hasAuthorship W2145338511A5073892799 @default.
• W2145338511 hasAuthorship W2145338511A5087160650 @default.
• W2145338511 hasAuthorship W2145338511A5091159415 @default.
• W2145338511 hasBestOaLocation W21453385112 @default.
• W2145338511 hasConcept C104317684 @default.
• W2145338511 hasConcept C119056186 @default.
• W2145338511 hasConcept C150194340 @default.
• W2145338511 hasConcept C153911025 @default.
• W2145338511 hasConcept C190727270 @default.
• W2145338511 hasConcept C203014093 @default.
• W2145338511 hasConcept C2778461978 @default.
• W2145338511 hasConcept C2778729363 @default.
• W2145338511 hasConcept C2779282312 @default.
• W2145338511 hasConcept C33288867 @default.
• W2145338511 hasConcept C41091548 @default.
• W2145338511 hasConcept C502942594 @default.
• W2145338511 hasConcept C54355233 @default.
• W2145338511 hasConcept C86803240 @default.
• W2145338511 hasConceptScore W2145338511C104317684 @default.
• W2145338511 hasConceptScore W2145338511C119056186 @default.
• W2145338511 hasConceptScore W2145338511C150194340 @default.
• W2145338511 hasConceptScore W2145338511C153911025 @default.
• W2145338511 hasConceptScore W2145338511C190727270 @default.
• W2145338511 hasConceptScore W2145338511C203014093 @default.
• W2145338511 hasConceptScore W2145338511C2778461978 @default.

• next