FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2145340147> ?p ?o ?g. }

• W2145340147 endingPage "630" @default.
• W2145340147 startingPage "624" @default.
• W2145340147 abstract "Objective Resveratrol (Res) is known to inhibit adhesion of numerous malignancies though its effect on an adherence of ovarian cancer cells to peritoneal mesothelium remains undefined. Methods To address this issue, ovarian cancer cells (A2780, OVCAR-3, SKOV-3) were subjected to Res (10, 50, 100 μM), and then their adhesion to omentum-derived human peritoneal mesothelial cells (HPMCs) was assayed. Results The study showed that Res inhibits adhesion of all ovarian cancer cell lines investigated. More importantly, this effect was evident either when cancer cells were directly treated with Res (cell-dependent activity) or when intact cancer cells were pretreated with conditioned medium (CM) generated by their counterparts subjected to Res (medium-dependent activity). Cell-dependent activity of Res has been recognized to be linked with decreased level of cellular α5β1 integrins which decreased functionality corresponds with reduced efficiency of cancer cell adhesion. Medium-related effects have been, in turn, associated with up-regulated secretion of soluble HA to environment (CM). The experiments with exogenous HA revealed the inverse relation between HA concentration in CM and cancer cell adhesion. When the CM from cells subjected with Res (with elevated HA) was supplemented with hyaluronidase, the restoration of cell adhesive capabilities occurred. Conclusions Our studies evidenced that Res affects ovarian cancer cell adhesion to HPMCs by decreasing cellular α5β1 integrin level and by increasing the secretion of HA to environment." @default.
• W2145340147 created "2016-06-24" @default.
• W2145340147 creator A5007053987 @default.
• W2145340147 creator A5028479896 @default.
• W2145340147 creator A5050558928 @default.
• W2145340147 date "2014-09-01" @default.
• W2145340147 modified "2023-10-15" @default.
• W2145340147 title "Resveratrol inhibits ovarian cancer cell adhesion to peritoneal mesothelium in vitro by modulating the production of α5β1 integrins and hyaluronic acid" @default.
• W2145340147 cites W1599728413 @default.
• W2145340147 cites W1856257838 @default.
• W2145340147 cites W1965104086 @default.
• W2145340147 cites W1984547449 @default.
• W2145340147 cites W1998953469 @default.
• W2145340147 cites W2002472109 @default.
• W2145340147 cites W2006609360 @default.
• W2145340147 cites W2016537572 @default.
• W2145340147 cites W2018808185 @default.
• W2145340147 cites W2036019161 @default.
• W2145340147 cites W2045306157 @default.
• W2145340147 cites W2065313953 @default.
• W2145340147 cites W2070914830 @default.
• W2145340147 cites W2082513866 @default.
• W2145340147 cites W2089916163 @default.
• W2145340147 cites W2095299663 @default.
• W2145340147 cites W2098275650 @default.
• W2145340147 cites W2108638545 @default.
• W2145340147 cites W2109289552 @default.
• W2145340147 cites W2114605941 @default.
• W2145340147 cites W2125253537 @default.
• W2145340147 cites W2134710794 @default.
• W2145340147 cites W2137877608 @default.
• W2145340147 cites W2146860811 @default.
• W2145340147 cites W2162589718 @default.
• W2145340147 cites W2168056388 @default.
• W2145340147 doi "https://doi.org/10.1016/j.ygyno.2014.06.022" @default.
• W2145340147 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24995580" @default.
• W2145340147 hasPublicationYear "2014" @default.
• W2145340147 type Work @default.
• W2145340147 sameAs 2145340147 @default.
• W2145340147 citedByCount "33" @default.
• W2145340147 countsByYear W21453401472014 @default.
• W2145340147 countsByYear W21453401472015 @default.
• W2145340147 countsByYear W21453401472016 @default.
• W2145340147 countsByYear W21453401472017 @default.
• W2145340147 countsByYear W21453401472018 @default.
• W2145340147 countsByYear W21453401472019 @default.
• W2145340147 countsByYear W21453401472020 @default.
• W2145340147 countsByYear W21453401472021 @default.
• W2145340147 countsByYear W21453401472022 @default.
• W2145340147 countsByYear W21453401472023 @default.
• W2145340147 crossrefType "journal-article" @default.
• W2145340147 hasAuthorship W2145340147A5007053987 @default.
• W2145340147 hasAuthorship W2145340147A5028479896 @default.
• W2145340147 hasAuthorship W2145340147A5050558928 @default.
• W2145340147 hasConcept C105702510 @default.
• W2145340147 hasConcept C121608353 @default.
• W2145340147 hasConcept C126322002 @default.
• W2145340147 hasConcept C142724271 @default.
• W2145340147 hasConcept C1491633281 @default.
• W2145340147 hasConcept C178790620 @default.
• W2145340147 hasConcept C185592680 @default.
• W2145340147 hasConcept C195687474 @default.
• W2145340147 hasConcept C2776816829 @default.
• W2145340147 hasConcept C2777529286 @default.
• W2145340147 hasConcept C2779747549 @default.
• W2145340147 hasConcept C2780427987 @default.
• W2145340147 hasConcept C2909640154 @default.
• W2145340147 hasConcept C502942594 @default.
• W2145340147 hasConcept C54355233 @default.
• W2145340147 hasConcept C55493867 @default.
• W2145340147 hasConcept C71924100 @default.
• W2145340147 hasConcept C81885089 @default.
• W2145340147 hasConcept C84416704 @default.
• W2145340147 hasConcept C85789140 @default.
• W2145340147 hasConcept C86803240 @default.
• W2145340147 hasConcept C95444343 @default.
• W2145340147 hasConcept C96232424 @default.
• W2145340147 hasConcept C98274493 @default.
• W2145340147 hasConceptScore W2145340147C105702510 @default.
• W2145340147 hasConceptScore W2145340147C121608353 @default.
• W2145340147 hasConceptScore W2145340147C126322002 @default.
• W2145340147 hasConceptScore W2145340147C142724271 @default.
• W2145340147 hasConceptScore W2145340147C1491633281 @default.
• W2145340147 hasConceptScore W2145340147C178790620 @default.
• W2145340147 hasConceptScore W2145340147C185592680 @default.
• W2145340147 hasConceptScore W2145340147C195687474 @default.
• W2145340147 hasConceptScore W2145340147C2776816829 @default.
• W2145340147 hasConceptScore W2145340147C2777529286 @default.
• W2145340147 hasConceptScore W2145340147C2779747549 @default.
• W2145340147 hasConceptScore W2145340147C2780427987 @default.
• W2145340147 hasConceptScore W2145340147C2909640154 @default.
• W2145340147 hasConceptScore W2145340147C502942594 @default.
• W2145340147 hasConceptScore W2145340147C54355233 @default.
• W2145340147 hasConceptScore W2145340147C55493867 @default.
• W2145340147 hasConceptScore W2145340147C71924100 @default.
• W2145340147 hasConceptScore W2145340147C81885089 @default.
• W2145340147 hasConceptScore W2145340147C84416704 @default.
• W2145340147 hasConceptScore W2145340147C85789140 @default.

• next