FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2145375037> ?p ?o ?g. }

• W2145375037 endingPage "345" @default.
• W2145375037 startingPage "336" @default.
• W2145375037 abstract "Quercetin has been described as having a wide range of beneficial effects in humans, ranging from anti-carcinogenic properties to reducing the risk of CVD. Nevertheless, underlying molecular mechanisms have been mostly investigated in vitro . Here, we tested whether a daily supplementation of quercetin leads to reproducible changes in human monocyte gene expression profiles. In study I, quercetin in varying dosages was given to healthy subjects for 2 weeks. RNA from monocytes isolated at the beginning and end of the study from subjects receiving 150 mg quercetin per d was subjected to transcriptome-wide microarray analysis. In study II, a double-blind cross-over study, twenty subjects exhibiting a ‘cardiovascular risk phenotype’ received 150 mg quercetin or placebo daily for 6 weeks each and served as the verification group. Microarray analysis revealed a number of differentially expressed genes. The most significantly represented functional groups were those of the immune system, nucleic acid metabolism, apoptosis and O -glycan biosynthesis. Twenty-four genes were chosen for technical replication and independent verification by quantitative real-time PCR. When comparing placebo and quercetin treatment, four genes showed significantly different expression changes ( C1GALT1 , O -glycan biosynthesis; GM2A , glycolipid catabolism; HDGF , cell proliferation; SERPINB9 , apoptosis). However, these were minimal in respect to magnitude of fold change. In conclusion, although microarray analysis revealed extensive effects of quercetin on gene expression, the employment of a placebo-controlled study design showed no comparable results for twenty-four verification targets. This emphasises the need for stringent designs in nutritional intervention studies with the aim to identify relevant changes in gene expression." @default.
• W2145375037 created "2016-06-24" @default.
• W2145375037 creator A5009883407 @default.
• W2145375037 creator A5050205832 @default.
• W2145375037 creator A5054741610 @default.
• W2145375037 creator A5065363011 @default.
• W2145375037 creator A5066342591 @default.
• W2145375037 creator A5082605152 @default.
• W2145375037 date "2010-04-26" @default.
• W2145375037 modified "2023-10-14" @default.
• W2145375037 title "Quercetin supplementation and its effect on human monocyte gene expression profiles <i>in vivo</i>" @default.
• W2145375037 cites W1544923801 @default.
• W2145375037 cites W1879358083 @default.
• W2145375037 cites W1965606609 @default.
• W2145375037 cites W1967906263 @default.
• W2145375037 cites W1967964480 @default.
• W2145375037 cites W1980458730 @default.
• W2145375037 cites W1984429650 @default.
• W2145375037 cites W1987111733 @default.
• W2145375037 cites W1996795806 @default.
• W2145375037 cites W2006167391 @default.
• W2145375037 cites W2010807769 @default.
• W2145375037 cites W2014018523 @default.
• W2145375037 cites W2023056790 @default.
• W2145375037 cites W2028544092 @default.
• W2145375037 cites W2034879947 @default.
• W2145375037 cites W2056933088 @default.
• W2145375037 cites W2057933641 @default.
• W2145375037 cites W2061142443 @default.
• W2145375037 cites W2065250857 @default.
• W2145375037 cites W2066345711 @default.
• W2145375037 cites W2083476316 @default.
• W2145375037 cites W2088578855 @default.
• W2145375037 cites W2107277218 @default.
• W2145375037 cites W2111797455 @default.
• W2145375037 cites W2112532879 @default.
• W2145375037 cites W2114502253 @default.
• W2145375037 cites W2122683221 @default.
• W2145375037 cites W2125054151 @default.
• W2145375037 cites W2127310510 @default.
• W2145375037 cites W2127798662 @default.
• W2145375037 cites W2129133439 @default.
• W2145375037 cites W2133347335 @default.
• W2145375037 cites W2137794561 @default.
• W2145375037 cites W2144618543 @default.
• W2145375037 cites W2159053661 @default.
• W2145375037 cites W2164159495 @default.
• W2145375037 cites W2168918080 @default.
• W2145375037 cites W2614442853 @default.
• W2145375037 doi "https://doi.org/10.1017/s0007114510000711" @default.
• W2145375037 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20416132" @default.
• W2145375037 hasPublicationYear "2010" @default.
• W2145375037 type Work @default.
• W2145375037 sameAs 2145375037 @default.
• W2145375037 citedByCount "38" @default.
• W2145375037 countsByYear W21453750372012 @default.
• W2145375037 countsByYear W21453750372014 @default.
• W2145375037 countsByYear W21453750372015 @default.
• W2145375037 countsByYear W21453750372016 @default.
• W2145375037 countsByYear W21453750372017 @default.
• W2145375037 countsByYear W21453750372018 @default.
• W2145375037 countsByYear W21453750372019 @default.
• W2145375037 countsByYear W21453750372020 @default.
• W2145375037 countsByYear W21453750372021 @default.
• W2145375037 countsByYear W21453750372023 @default.
• W2145375037 crossrefType "journal-article" @default.
• W2145375037 hasAuthorship W2145375037A5009883407 @default.
• W2145375037 hasAuthorship W2145375037A5050205832 @default.
• W2145375037 hasAuthorship W2145375037A5054741610 @default.
• W2145375037 hasAuthorship W2145375037A5065363011 @default.
• W2145375037 hasAuthorship W2145375037A5066342591 @default.
• W2145375037 hasAuthorship W2145375037A5082605152 @default.
• W2145375037 hasBestOaLocation W21453750371 @default.
• W2145375037 hasConcept C104317684 @default.
• W2145375037 hasConcept C150194340 @default.
• W2145375037 hasConcept C153911025 @default.
• W2145375037 hasConcept C162317418 @default.
• W2145375037 hasConcept C186836561 @default.
• W2145375037 hasConcept C207001950 @default.
• W2145375037 hasConcept C2778004101 @default.
• W2145375037 hasConcept C2781263971 @default.
• W2145375037 hasConcept C54355233 @default.
• W2145375037 hasConcept C55493867 @default.
• W2145375037 hasConcept C8415881 @default.
• W2145375037 hasConcept C86803240 @default.
• W2145375037 hasConcept C98274493 @default.
• W2145375037 hasConceptScore W2145375037C104317684 @default.
• W2145375037 hasConceptScore W2145375037C150194340 @default.
• W2145375037 hasConceptScore W2145375037C153911025 @default.
• W2145375037 hasConceptScore W2145375037C162317418 @default.
• W2145375037 hasConceptScore W2145375037C186836561 @default.
• W2145375037 hasConceptScore W2145375037C207001950 @default.
• W2145375037 hasConceptScore W2145375037C2778004101 @default.
• W2145375037 hasConceptScore W2145375037C2781263971 @default.
• W2145375037 hasConceptScore W2145375037C54355233 @default.
• W2145375037 hasConceptScore W2145375037C55493867 @default.
• W2145375037 hasConceptScore W2145375037C8415881 @default.
• W2145375037 hasConceptScore W2145375037C86803240 @default.

• next