FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2145375225> ?p ?o ?g. }

• W2145375225 endingPage "8858" @default.
• W2145375225 startingPage "8848" @default.
• W2145375225 abstract "Herpes simplex virus 1 (HSV-1) can establish life-long latent infection in sensory neurons, from which periodic reactivation can occur. During latency, viral gene expression is largely restricted to the latency-associated transcripts (LATs). While not essential for any phase of latency, to date the LATs have been shown to increase the efficiency of both establishment and reactivation of latency in small-animal models. We sought to investigate the role of LAT expression in the frequency of latency establishment within the ROSA26R reporter mouse model utilizing Cre recombinase-encoding recombinant viruses harboring deletions of the core LAT promoter (LAP) region. HSV-1 LAT expression was observed to influence the number of latently infected neurons in trigeminal but not dorsal root ganglia. Furthermore, the relative frequencies of latency establishment of LAT-positive and LAT-negative viruses are influenced by the inoculum dose following infection of the mouse whisker pads. Finally, analysis of the infected cell population at two latent time points revealed a relative loss of latently infected cells in the absence of LAT expression. We conclude that the HSV-1 LATs facilitate the long-term stability of the latent cell population within the infected host and that interpretation of LAT establishment phenotypes is influenced by infection methodology." @default.
• W2145375225 created "2016-06-24" @default.
• W2145375225 creator A5001463364 @default.
• W2145375225 creator A5031026129 @default.
• W2145375225 creator A5063488783 @default.
• W2145375225 creator A5091463595 @default.
• W2145375225 date "2012-08-15" @default.
• W2145375225 modified "2023-10-18" @default.
• W2145375225 title "Influence of Herpes Simplex Virus 1 Latency-Associated Transcripts on the Establishment and Maintenance of Latency in the ROSA26R Reporter Mouse Model" @default.
• W2145375225 cites W1578735362 @default.
• W2145375225 cites W1768274470 @default.
• W2145375225 cites W1942310387 @default.
• W2145375225 cites W1944137027 @default.
• W2145375225 cites W1946890749 @default.
• W2145375225 cites W1976103347 @default.
• W2145375225 cites W1980305746 @default.
• W2145375225 cites W1988999154 @default.
• W2145375225 cites W1991010205 @default.
• W2145375225 cites W1997624180 @default.
• W2145375225 cites W2007735134 @default.
• W2145375225 cites W2037487422 @default.
• W2145375225 cites W2038873012 @default.
• W2145375225 cites W2038903818 @default.
• W2145375225 cites W2039026634 @default.
• W2145375225 cites W2051160943 @default.
• W2145375225 cites W2056295530 @default.
• W2145375225 cites W2056650797 @default.
• W2145375225 cites W2062705788 @default.
• W2145375225 cites W2080846870 @default.
• W2145375225 cites W2100092640 @default.
• W2145375225 cites W2101899737 @default.
• W2145375225 cites W2104280546 @default.
• W2145375225 cites W2104845462 @default.
• W2145375225 cites W2112244651 @default.
• W2145375225 cites W2112322477 @default.
• W2145375225 cites W2113334723 @default.
• W2145375225 cites W2115772994 @default.
• W2145375225 cites W2118749448 @default.
• W2145375225 cites W2118793944 @default.
• W2145375225 cites W2122280181 @default.
• W2145375225 cites W2122466812 @default.
• W2145375225 cites W2123903713 @default.
• W2145375225 cites W2126134216 @default.
• W2145375225 cites W2127846162 @default.
• W2145375225 cites W2129350965 @default.
• W2145375225 cites W2136798456 @default.
• W2145375225 cites W2137698911 @default.
• W2145375225 cites W2140178603 @default.
• W2145375225 cites W2141668962 @default.
• W2145375225 cites W2141955811 @default.
• W2145375225 cites W2142082591 @default.
• W2145375225 cites W2144467503 @default.
• W2145375225 cites W2147678533 @default.
• W2145375225 cites W2151694296 @default.
• W2145375225 cites W2152203907 @default.
• W2145375225 cites W2156964094 @default.
• W2145375225 cites W2162751422 @default.
• W2145375225 cites W2163424373 @default.
• W2145375225 cites W2165609174 @default.
• W2145375225 cites W2168808708 @default.
• W2145375225 doi "https://doi.org/10.1128/jvi.00652-12" @default.
• W2145375225 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3421754" @default.
• W2145375225 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22696655" @default.
• W2145375225 hasPublicationYear "2012" @default.
• W2145375225 type Work @default.
• W2145375225 sameAs 2145375225 @default.
• W2145375225 citedByCount "24" @default.
• W2145375225 countsByYear W21453752252012 @default.
• W2145375225 countsByYear W21453752252013 @default.
• W2145375225 countsByYear W21453752252014 @default.
• W2145375225 countsByYear W21453752252015 @default.
• W2145375225 countsByYear W21453752252016 @default.
• W2145375225 countsByYear W21453752252017 @default.
• W2145375225 countsByYear W21453752252018 @default.
• W2145375225 countsByYear W21453752252019 @default.
• W2145375225 countsByYear W21453752252020 @default.
• W2145375225 countsByYear W21453752252021 @default.
• W2145375225 crossrefType "journal-article" @default.
• W2145375225 hasAuthorship W2145375225A5001463364 @default.
• W2145375225 hasAuthorship W2145375225A5031026129 @default.
• W2145375225 hasAuthorship W2145375225A5063488783 @default.
• W2145375225 hasAuthorship W2145375225A5091463595 @default.
• W2145375225 hasBestOaLocation W21453752251 @default.
• W2145375225 hasConcept C104317684 @default.
• W2145375225 hasConcept C119599485 @default.
• W2145375225 hasConcept C127413603 @default.
• W2145375225 hasConcept C127716648 @default.
• W2145375225 hasConcept C140704245 @default.
• W2145375225 hasConcept C144024400 @default.
• W2145375225 hasConcept C149923435 @default.
• W2145375225 hasConcept C159047783 @default.
• W2145375225 hasConcept C2522874641 @default.
• W2145375225 hasConcept C2778852064 @default.
• W2145375225 hasConcept C2781196997 @default.
• W2145375225 hasConcept C2908647359 @default.
• W2145375225 hasConcept C2910737674 @default.
• W2145375225 hasConcept C54355233 @default.
• W2145375225 hasConcept C82876162 @default.

• next