FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2145385087> ?p ?o ?g. }

• W2145385087 endingPage "18759" @default.
• W2145385087 startingPage "18754" @default.
• W2145385087 abstract "Schizosaccharomyces pombe cells switch mating type by replacing genetic information at the expressed mat1 locus with sequences copied from mat2-P or mat3-M silent donor loci. The choice of donor locus is dictated by cell type, such that mat2 is the preferred donor in M cells and mat3 is the preferred donor in P cells. Donor choice involves a recombination-promoting complex (RPC) containing Swi2 and Swi5. In P cells, the RPC localizes to a specific DNA element located adjacent to mat3 , but in M cells it spreads across the silent mating-type region, including mat2-P . This differential distribution of the RPC regulates nonrandom choice of donors. However, cell-type–specific differences in RPC localization are not understood. Here we show that the mat1-M –encoded factor Mc, which shares structural and functional similarities with the male sex-determining factor SRY, is highly enriched at the swi2 and swi5 loci and promotes elevated levels of RPC components. Loss of Mc reduces Swi2 and Swi5 to levels comparable to those in P cells and disrupts RPC spreading across the mat2/3 region. Mc also localizes to loci expressed preferentially in M cells and to retrotransposon LTRs. We demonstrate that Mc localization at LTRs and at swi2 requires Abp1, a homolog of transposon-derived CENP-B protein and that loss of Abp1 impairs Swi2 protein expression and the donor choice mechanism. These results suggest that Mc modulates levels of recombination factors, which is important for mating-type donor selection and for the biased gene conversion observed during meiosis, where M cells serve as preferential donors of genetic information." @default.
• W2145385087 created "2016-06-24" @default.
• W2145385087 creator A5020713009 @default.
• W2145385087 creator A5030370296 @default.
• W2145385087 creator A5045723947 @default.
• W2145385087 creator A5060444754 @default.
• W2145385087 creator A5060779845 @default.
• W2145385087 creator A5090748604 @default.
• W2145385087 date "2011-10-31" @default.
• W2145385087 modified "2023-10-16" @default.
• W2145385087 title "A homolog of male sex-determining factor SRY cooperates with a transposon-derived CENP-B protein to control sex-specific directed recombination" @default.
• W2145385087 cites W1562877571 @default.
• W2145385087 cites W1584615787 @default.
• W2145385087 cites W1669659061 @default.
• W2145385087 cites W1935802173 @default.
• W2145385087 cites W1964418797 @default.
• W2145385087 cites W1965416567 @default.
• W2145385087 cites W1987198779 @default.
• W2145385087 cites W1989943265 @default.
• W2145385087 cites W1990265320 @default.
• W2145385087 cites W1994181100 @default.
• W2145385087 cites W2003345607 @default.
• W2145385087 cites W2007498729 @default.
• W2145385087 cites W2012383157 @default.
• W2145385087 cites W2012479817 @default.
• W2145385087 cites W2013246689 @default.
• W2145385087 cites W2013673778 @default.
• W2145385087 cites W2017165841 @default.
• W2145385087 cites W2022584463 @default.
• W2145385087 cites W2025972514 @default.
• W2145385087 cites W2026304022 @default.
• W2145385087 cites W2029301727 @default.
• W2145385087 cites W2030002436 @default.
• W2145385087 cites W2031956843 @default.
• W2145385087 cites W2042368221 @default.
• W2145385087 cites W2052770408 @default.
• W2145385087 cites W2055684843 @default.
• W2145385087 cites W2057089136 @default.
• W2145385087 cites W2063957348 @default.
• W2145385087 cites W2064589581 @default.
• W2145385087 cites W2065748300 @default.
• W2145385087 cites W2067487392 @default.
• W2145385087 cites W2073312551 @default.
• W2145385087 cites W2081970237 @default.
• W2145385087 cites W2082989673 @default.
• W2145385087 cites W2097422139 @default.
• W2145385087 cites W2105650420 @default.
• W2145385087 cites W2115840843 @default.
• W2145385087 cites W2123161025 @default.
• W2145385087 cites W2125338577 @default.
• W2145385087 cites W2128320997 @default.
• W2145385087 cites W2141976844 @default.
• W2145385087 cites W2145781746 @default.
• W2145385087 cites W2160789731 @default.
• W2145385087 cites W2164607911 @default.
• W2145385087 cites W2167863101 @default.
• W2145385087 cites W2168728866 @default.
• W2145385087 cites W216926159 @default.
• W2145385087 cites W2336109233 @default.
• W2145385087 cites W274783243 @default.
• W2145385087 cites W3211005720 @default.
• W2145385087 doi "https://doi.org/10.1073/pnas.1109988108" @default.
• W2145385087 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3219157" @default.
• W2145385087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22042869" @default.
• W2145385087 hasPublicationYear "2011" @default.
• W2145385087 type Work @default.
• W2145385087 sameAs 2145385087 @default.
• W2145385087 citedByCount "15" @default.
• W2145385087 countsByYear W21453850872012 @default.
• W2145385087 countsByYear W21453850872013 @default.
• W2145385087 countsByYear W21453850872014 @default.
• W2145385087 countsByYear W21453850872015 @default.
• W2145385087 countsByYear W21453850872016 @default.
• W2145385087 countsByYear W21453850872017 @default.
• W2145385087 countsByYear W21453850872018 @default.
• W2145385087 countsByYear W21453850872022 @default.
• W2145385087 countsByYear W21453850872023 @default.
• W2145385087 crossrefType "journal-article" @default.
• W2145385087 hasAuthorship W2145385087A5020713009 @default.
• W2145385087 hasAuthorship W2145385087A5030370296 @default.
• W2145385087 hasAuthorship W2145385087A5045723947 @default.
• W2145385087 hasAuthorship W2145385087A5060444754 @default.
• W2145385087 hasAuthorship W2145385087A5060779845 @default.
• W2145385087 hasAuthorship W2145385087A5090748604 @default.
• W2145385087 hasBestOaLocation W21453850871 @default.
• W2145385087 hasConcept C104317684 @default.
• W2145385087 hasConcept C143065580 @default.
• W2145385087 hasConcept C153911025 @default.
• W2145385087 hasConcept C2776519988 @default.
• W2145385087 hasConcept C2777576037 @default.
• W2145385087 hasConcept C2779429346 @default.
• W2145385087 hasConcept C46909000 @default.
• W2145385087 hasConcept C4918238 @default.
• W2145385087 hasConcept C54355233 @default.
• W2145385087 hasConcept C84597430 @default.
• W2145385087 hasConcept C86803240 @default.
• W2145385087 hasConceptScore W2145385087C104317684 @default.
• W2145385087 hasConceptScore W2145385087C143065580 @default.

• next