FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2145389713> ?p ?o ?g. }

• W2145389713 endingPage "1788" @default.
• W2145389713 startingPage "1781" @default.
• W2145389713 abstract "ABSTRACT Cathelicidins are peptide components of the innate immune system of mammals. Apart from exerting a direct antibiotic activity, they can also trigger specific defense responses in the host. Their roles in various pathophysiological conditions have been studied, but there is a lack of published information on their expression and activities in the context of mastitis. The aims of this study were to investigate the expression of the bovine cathelicidins BMAP-27, BMAP-28, Bac5, and indolicidin in healthy and infected mammary tissue and in lipopolysaccharide (LPS)-treated cells, to determine their activities against bacteria isolated from bovine mastitis, and to examine their potentials to trigger defense responses in bovine mammary cells. The genes were found to be upregulated in LPS-stimulated neutrophils, but not in infected quarters or epithelial cells. All peptides showed a variably broad spectrum of activity against 28 bacterial isolates from bovine mastitis (MIC values, 0.5 to 32 μM), some of which were antibiotic resistant. The activity of each peptide was significantly enhanced when it was pairwise tested with the other peptides, reaching the synergy threshold when indolicidin was present. The bactericidal activity was sensitive to milk components; BMAP-27 and -28 were highly effective in mastitic bovine milk and inhibited in milk from healthy cows. Both peptides were also active in whey and in blood serum and triggered the expression of tumor necrosis factor alpha (TNF-α) in bovine mammary epithelial cells. Our results indicate multiple roles for the bovine cathelicidins in mastitis, with complementary and mutually enhanced antimicrobial activities against causative pathogens and the capacity to activate host cells." @default.
• W2145389713 created "2016-06-24" @default.
• W2145389713 creator A5006615790 @default.
• W2145389713 creator A5007224783 @default.
• W2145389713 creator A5009913321 @default.
• W2145389713 creator A5024859711 @default.
• W2145389713 creator A5031817237 @default.
• W2145389713 creator A5057509192 @default.
• W2145389713 creator A5075476157 @default.
• W2145389713 creator A5084500134 @default.
• W2145389713 date "2010-04-01" @default.
• W2145389713 modified "2023-10-01" @default.
• W2145389713 title "Broad-Spectrum Activity against Bacterial Mastitis Pathogens and Activation of Mammary Epithelial Cells Support a Protective Role of Neutrophil Cathelicidins in Bovine Mastitis" @default.
• W2145389713 cites W1558729549 @default.
• W2145389713 cites W1926920621 @default.
• W2145389713 cites W1973137043 @default.
• W2145389713 cites W1977160855 @default.
• W2145389713 cites W1981705708 @default.
• W2145389713 cites W1982095205 @default.
• W2145389713 cites W1983521156 @default.
• W2145389713 cites W1983987058 @default.
• W2145389713 cites W1986052203 @default.
• W2145389713 cites W1992267311 @default.
• W2145389713 cites W1993355081 @default.
• W2145389713 cites W2007524080 @default.
• W2145389713 cites W201024662 @default.
• W2145389713 cites W2013418133 @default.
• W2145389713 cites W2014269957 @default.
• W2145389713 cites W2016562927 @default.
• W2145389713 cites W2018533615 @default.
• W2145389713 cites W2020799333 @default.
• W2145389713 cites W2022998979 @default.
• W2145389713 cites W2027620167 @default.
• W2145389713 cites W2030499542 @default.
• W2145389713 cites W2031400337 @default.
• W2145389713 cites W2031576296 @default.
• W2145389713 cites W2032937685 @default.
• W2145389713 cites W2035769940 @default.
• W2145389713 cites W2038233222 @default.
• W2145389713 cites W2042455091 @default.
• W2145389713 cites W2046615700 @default.
• W2145389713 cites W2050736926 @default.
• W2145389713 cites W2051142131 @default.
• W2145389713 cites W2054602599 @default.
• W2145389713 cites W2056700681 @default.
• W2145389713 cites W2069702100 @default.
• W2145389713 cites W2070213312 @default.
• W2145389713 cites W2072247634 @default.
• W2145389713 cites W2078399145 @default.
• W2145389713 cites W2082426484 @default.
• W2145389713 cites W2085370595 @default.
• W2145389713 cites W2097503035 @default.
• W2145389713 cites W2097515194 @default.
• W2145389713 cites W2101158888 @default.
• W2145389713 cites W2104651715 @default.
• W2145389713 cites W2113336881 @default.
• W2145389713 cites W2121533469 @default.
• W2145389713 cites W2124831299 @default.
• W2145389713 cites W2126606592 @default.
• W2145389713 cites W2131187667 @default.
• W2145389713 cites W2133668257 @default.
• W2145389713 cites W2149168973 @default.
• W2145389713 cites W2153041745 @default.
• W2145389713 cites W2162318948 @default.
• W2145389713 cites W2165094253 @default.
• W2145389713 cites W2171139695 @default.
• W2145389713 doi "https://doi.org/10.1128/iai.01090-09" @default.
• W2145389713 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2849419" @default.
• W2145389713 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20100862" @default.
• W2145389713 hasPublicationYear "2010" @default.
• W2145389713 type Work @default.
• W2145389713 sameAs 2145389713 @default.
• W2145389713 citedByCount "72" @default.
• W2145389713 countsByYear W21453897132012 @default.
• W2145389713 countsByYear W21453897132013 @default.
• W2145389713 countsByYear W21453897132014 @default.
• W2145389713 countsByYear W21453897132015 @default.
• W2145389713 countsByYear W21453897132016 @default.
• W2145389713 countsByYear W21453897132017 @default.
• W2145389713 countsByYear W21453897132018 @default.
• W2145389713 countsByYear W21453897132019 @default.
• W2145389713 countsByYear W21453897132020 @default.
• W2145389713 countsByYear W21453897132021 @default.
• W2145389713 countsByYear W21453897132022 @default.
• W2145389713 countsByYear W21453897132023 @default.
• W2145389713 crossrefType "journal-article" @default.
• W2145389713 hasAuthorship W2145389713A5006615790 @default.
• W2145389713 hasAuthorship W2145389713A5007224783 @default.
• W2145389713 hasAuthorship W2145389713A5009913321 @default.
• W2145389713 hasAuthorship W2145389713A5024859711 @default.
• W2145389713 hasAuthorship W2145389713A5031817237 @default.
• W2145389713 hasAuthorship W2145389713A5057509192 @default.
• W2145389713 hasAuthorship W2145389713A5075476157 @default.
• W2145389713 hasAuthorship W2145389713A5084500134 @default.
• W2145389713 hasBestOaLocation W21453897132 @default.
• W2145389713 hasConcept C121608353 @default.
• W2145389713 hasConcept C136449434 @default.
• W2145389713 hasConcept C151730666 @default.

• next