FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2145393119> ?p ?o ?g. }

• W2145393119 endingPage "155" @default.
• W2145393119 startingPage "137" @default.
• W2145393119 abstract "In the present work, we investigate whether changes in excitation–contraction (EC) coupling mode occur in skeletal muscles from ageing mammals by examining the dependence of EC coupling on extracellular Ca 2+ . Single intact muscle fibres from flexor digitorum brevis muscles from young (2–6 months) and old (23–30 months) mice were subjected to tetanic contractile protocols in the presence and absence of external Ca 2+ . Contractile experiments in the absence of external Ca 2+ show that about half of muscle fibres from old mice are dependent upon external Ca 2+ for maintaining maximal tetanic force output, while young fibres are not. Decreased force in the absence of external Ca 2+ was not due to changes in charge movement as revealed by whole‐cell patch‐clamp experiments. Ca 2+ transients, measured by fluo‐4 fluorescence, declined in voltage‐clamped fibres from old mice in the absence of external Ca 2+ . Similarly, Ca 2+ transients declined in parallel with tetanic contractile force in single intact fibres. Examination of inward Ca 2+ current and of mRNA and protein assays suggest that these changes in EC coupling mode are not due to shifts in dihydropyridine receptor (DHPR) and/or ryanodine receptor (RyR) isoforms. These results indicate that a change in EC coupling mode occurs in a population of fibres in ageing skeletal muscle, and is responsible for the age‐related dependence on extracellular Ca 2+ ." @default.
• W2145393119 created "2016-06-24" @default.
• W2145393119 creator A5013575262 @default.
• W2145393119 creator A5051643950 @default.
• W2145393119 creator A5065139443 @default.
• W2145393119 creator A5069070290 @default.
• W2145393119 creator A5074145313 @default.
• W2145393119 creator A5074509186 @default.
• W2145393119 date "2004-10-01" @default.
• W2145393119 modified "2023-10-12" @default.
• W2145393119 title "External Ca²⁺-dependent excitation-contraction coupling in a population of ageing mouse skeletal muscle fibres" @default.
• W2145393119 cites W144978566 @default.
• W2145393119 cites W1538327476 @default.
• W2145393119 cites W1565417780 @default.
• W2145393119 cites W1585949905 @default.
• W2145393119 cites W1628979938 @default.
• W2145393119 cites W1705241395 @default.
• W2145393119 cites W1963767531 @default.
• W2145393119 cites W1965850822 @default.
• W2145393119 cites W1972595067 @default.
• W2145393119 cites W1972765470 @default.
• W2145393119 cites W1973150566 @default.
• W2145393119 cites W1978167998 @default.
• W2145393119 cites W1986792633 @default.
• W2145393119 cites W1988119781 @default.
• W2145393119 cites W1988143758 @default.
• W2145393119 cites W1988421541 @default.
• W2145393119 cites W1989714306 @default.
• W2145393119 cites W1995550177 @default.
• W2145393119 cites W1997050207 @default.
• W2145393119 cites W1998318605 @default.
• W2145393119 cites W2003784210 @default.
• W2145393119 cites W2007462850 @default.
• W2145393119 cites W2010873798 @default.
• W2145393119 cites W2010894079 @default.
• W2145393119 cites W2011038097 @default.
• W2145393119 cites W2011533557 @default.
• W2145393119 cites W2018771017 @default.
• W2145393119 cites W2022068801 @default.
• W2145393119 cites W2022474937 @default.
• W2145393119 cites W2023758830 @default.
• W2145393119 cites W2024486028 @default.
• W2145393119 cites W2024929666 @default.
• W2145393119 cites W2029199558 @default.
• W2145393119 cites W2030970048 @default.
• W2145393119 cites W2034303015 @default.
• W2145393119 cites W2036247086 @default.
• W2145393119 cites W2036396000 @default.
• W2145393119 cites W2036424054 @default.
• W2145393119 cites W2036937904 @default.
• W2145393119 cites W2038562293 @default.
• W2145393119 cites W2039547987 @default.
• W2145393119 cites W2040097492 @default.
• W2145393119 cites W2055449968 @default.
• W2145393119 cites W2059647854 @default.
• W2145393119 cites W2062152852 @default.
• W2145393119 cites W2062278406 @default.
• W2145393119 cites W2063994440 @default.
• W2145393119 cites W2065205699 @default.
• W2145393119 cites W2066155831 @default.
• W2145393119 cites W2067297047 @default.
• W2145393119 cites W2070250903 @default.
• W2145393119 cites W2078360969 @default.
• W2145393119 cites W2084205842 @default.
• W2145393119 cites W2087651417 @default.
• W2145393119 cites W2088742076 @default.
• W2145393119 cites W2089500423 @default.
• W2145393119 cites W2090947749 @default.
• W2145393119 cites W2095546957 @default.
• W2145393119 cites W2099148544 @default.
• W2145393119 cites W2104439919 @default.
• W2145393119 cites W2111920828 @default.
• W2145393119 cites W2116214367 @default.
• W2145393119 cites W2117036053 @default.
• W2145393119 cites W2117991449 @default.
• W2145393119 cites W2123162312 @default.
• W2145393119 cites W2162731252 @default.
• W2145393119 cites W2168879806 @default.
• W2145393119 cites W2171238937 @default.
• W2145393119 cites W2296449474 @default.
• W2145393119 cites W2331053699 @default.
• W2145393119 cites W2408350377 @default.
• W2145393119 cites W2430752942 @default.
• W2145393119 cites W2480520884 @default.
• W2145393119 cites W4248828694 @default.
• W2145393119 cites W4253681301 @default.
• W2145393119 cites W4285719527 @default.
• W2145393119 doi "https://doi.org/10.1113/jphysiol.2004.067322" @default.
• W2145393119 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1665204" @default.
• W2145393119 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15297570" @default.
• W2145393119 hasPublicationYear "2004" @default.
• W2145393119 type Work @default.
• W2145393119 sameAs 2145393119 @default.
• W2145393119 citedByCount "45" @default.
• W2145393119 countsByYear W21453931192012 @default.
• W2145393119 countsByYear W21453931192013 @default.
• W2145393119 countsByYear W21453931192015 @default.
• W2145393119 countsByYear W21453931192020 @default.

• next