FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2145397300> ?p ?o ?g. }

• W2145397300 endingPage "743" @default.
• W2145397300 startingPage "739" @default.
• W2145397300 abstract "<b>Introduction:</b> Severe, sustained pulmonary arterial hypertension leads to a progressive reduction in exercise capacity, right heart failure and death. Use of intravenous epoprostenol has improved survival in adults, but data are limited in children. <b>Patients and methods:</b> This study included all 39 children treated with continuous intravenous epoprostenol since November 1997 at Great Ormond Street Hospital for Children (London, UK). Patients were aged 4 months to 17 years (median 5.4 years) at the onset of therapy. The male:female ratio was 1:1.3. 25 patients had idiopathic pulmonary arterial hypertension and 14 had pulmonary arterial hypertension associated with congenital heart disease, connective tissue disease, chronic lung disease or HIV. All were in WHO functional class III and IV. Mean pulmonary arterial pressure (SD) was 59 (17) mmHg and mean pulmonary vascular resistance was 23.3 (11.6) units×m². Patients were assessed regularly (2–3 monthly intervals) by physical examination, electrocardiography, transthoracic echocardiography and a 6-min walk test, when practicable. <b>Results:</b> The mean duration of follow-up was 27 (21) months. 7 patients died and 8 underwent transplantation. Cumulative survival at 1, 2 and 3 years was 94, 90 and 84%. The 6-min walking distance improved by a mean of 77 m (p<0.003). WHO functional class improved during the first year (p<0.001) and improvement was maintained for up to 3 years. Weight improved significantly from a baseline z score of −1.55 (1.74) to −1.16 (1.8) (p<0.03). 28 children had additional oral specific therapy. Hickman line changes were 0.33/patient year. <b>Conclusions:</b> Epoprostenol therapy improved survival, WHO functional class, exercise tolerance and ability to thrive in children with severe pulmonary arterial hypertension. Epoprostenol represents an effective and feasible therapy even in young children." @default.
• W2145397300 created "2016-06-24" @default.
• W2145397300 creator A5004208650 @default.
• W2145397300 creator A5021058279 @default.
• W2145397300 creator A5054893611 @default.
• W2145397300 creator A5088674324 @default.
• W2145397300 date "2007-06-01" @default.
• W2145397300 modified "2023-10-14" @default.
• W2145397300 title "Epoprostenol treatment in children with severe pulmonary hypertension" @default.
• W2145397300 cites W1538561877 @default.
• W2145397300 cites W1567539035 @default.
• W2145397300 cites W1840736932 @default.
• W2145397300 cites W1967215100 @default.
• W2145397300 cites W1970369512 @default.
• W2145397300 cites W1983508299 @default.
• W2145397300 cites W1988773573 @default.
• W2145397300 cites W1994219663 @default.
• W2145397300 cites W2023455463 @default.
• W2145397300 cites W2036778075 @default.
• W2145397300 cites W2037489482 @default.
• W2145397300 cites W2081318043 @default.
• W2145397300 cites W2093673373 @default.
• W2145397300 cites W2101213473 @default.
• W2145397300 cites W2129125190 @default.
• W2145397300 cites W2131409957 @default.
• W2145397300 cites W2131897774 @default.
• W2145397300 cites W2135510321 @default.
• W2145397300 cites W2136203952 @default.
• W2145397300 cites W2138117143 @default.
• W2145397300 cites W2138649273 @default.
• W2145397300 cites W2141987653 @default.
• W2145397300 cites W2145296727 @default.
• W2145397300 cites W2145860140 @default.
• W2145397300 cites W2148813221 @default.
• W2145397300 cites W2165261476 @default.
• W2145397300 cites W2321522617 @default.
• W2145397300 cites W4245666729 @default.
• W2145397300 doi "https://doi.org/10.1136/hrt.2006.096412" @default.
• W2145397300 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1955199" @default.
• W2145397300 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17065181" @default.
• W2145397300 hasPublicationYear "2007" @default.
• W2145397300 type Work @default.
• W2145397300 sameAs 2145397300 @default.
• W2145397300 citedByCount "106" @default.
• W2145397300 countsByYear W21453973002012 @default.
• W2145397300 countsByYear W21453973002013 @default.
• W2145397300 countsByYear W21453973002014 @default.
• W2145397300 countsByYear W21453973002015 @default.
• W2145397300 countsByYear W21453973002016 @default.
• W2145397300 countsByYear W21453973002017 @default.
• W2145397300 countsByYear W21453973002018 @default.
• W2145397300 countsByYear W21453973002019 @default.
• W2145397300 countsByYear W21453973002020 @default.
• W2145397300 countsByYear W21453973002021 @default.
• W2145397300 countsByYear W21453973002022 @default.
• W2145397300 countsByYear W21453973002023 @default.
• W2145397300 crossrefType "journal-article" @default.
• W2145397300 hasAuthorship W2145397300A5004208650 @default.
• W2145397300 hasAuthorship W2145397300A5021058279 @default.
• W2145397300 hasAuthorship W2145397300A5054893611 @default.
• W2145397300 hasAuthorship W2145397300A5088674324 @default.
• W2145397300 hasBestOaLocation W21453973002 @default.
• W2145397300 hasConcept C126322002 @default.
• W2145397300 hasConcept C141071460 @default.
• W2145397300 hasConcept C164705383 @default.
• W2145397300 hasConcept C2776178081 @default.
• W2145397300 hasConcept C2777714996 @default.
• W2145397300 hasConcept C2778198053 @default.
• W2145397300 hasConcept C2780074459 @default.
• W2145397300 hasConcept C2780930700 @default.
• W2145397300 hasConcept C2781448352 @default.
• W2145397300 hasConcept C2911091166 @default.
• W2145397300 hasConcept C58245268 @default.
• W2145397300 hasConcept C71924100 @default.
• W2145397300 hasConcept C84393581 @default.
• W2145397300 hasConceptScore W2145397300C126322002 @default.
• W2145397300 hasConceptScore W2145397300C141071460 @default.
• W2145397300 hasConceptScore W2145397300C164705383 @default.
• W2145397300 hasConceptScore W2145397300C2776178081 @default.
• W2145397300 hasConceptScore W2145397300C2777714996 @default.
• W2145397300 hasConceptScore W2145397300C2778198053 @default.
• W2145397300 hasConceptScore W2145397300C2780074459 @default.
• W2145397300 hasConceptScore W2145397300C2780930700 @default.
• W2145397300 hasConceptScore W2145397300C2781448352 @default.
• W2145397300 hasConceptScore W2145397300C2911091166 @default.
• W2145397300 hasConceptScore W2145397300C58245268 @default.
• W2145397300 hasConceptScore W2145397300C71924100 @default.
• W2145397300 hasConceptScore W2145397300C84393581 @default.
• W2145397300 hasIssue "6" @default.
• W2145397300 hasLocation W21453973001 @default.
• W2145397300 hasLocation W21453973002 @default.
• W2145397300 hasLocation W21453973003 @default.
• W2145397300 hasLocation W21453973004 @default.
• W2145397300 hasOpenAccess W2145397300 @default.
• W2145397300 hasPrimaryLocation W21453973001 @default.
• W2145397300 hasRelatedWork W1990047245 @default.
• W2145397300 hasRelatedWork W2120941518 @default.
• W2145397300 hasRelatedWork W2158672159 @default.

• next