Matches in SemOpenAlex for { <https://semopenalex.org/work/W2145402561> ?p ?o ?g. }
- W2145402561 endingPage "10" @default.
- W2145402561 startingPage "2" @default.
- W2145402561 abstract "The present paper presents a hypothesis aimed at explaining why venous leg ulcers, pressure ulcers, and diabetic foot ulcers develop into a chronic state. We propose that the lack of proper wound healing is at least in part caused by inefficient eradication of infecting, opportunistic pathogens, a situation reminiscent of chronic Pseudomonas aeruginosa infections found in patients suffering from cystic fibrosis (CF). We have analyzed sections from chronic wounds by fluorescence in situ hybridization and found distinct microcolonies—the basal structures of bacterial biofilms. Several researchers have previously reported that another important hallmark of biofilm formation is development of increased tolerance to various antimicrobial measures and treatments. Furthermore, the immune response to infecting bacteria in the cystic fibrosis lung is dominated by polymorphonuclear neutrophils (PMNs), and we have recently shown that in vitro biofilms of P. aeruginosa produce a shielding mechanism that offers protection from the phagocytic activity of PMNs.1, 2 We hypothesize that the presence of P. aeruginosa in biofilms, and the lack of concomitant elimination by attended PMNs, are the main causes of inefficient eradication by antibiotic treatment and antimicrobial activity of the innate immune system, respectively." @default.
- W2145402561 created "2016-06-24" @default.
- W2145402561 creator A5003553464 @default.
- W2145402561 creator A5004988031 @default.
- W2145402561 creator A5035132198 @default.
- W2145402561 creator A5040137110 @default.
- W2145402561 creator A5052998611 @default.
- W2145402561 creator A5065577052 @default.
- W2145402561 creator A5070872896 @default.
- W2145402561 creator A5086191926 @default.
- W2145402561 date "2007-10-03" @default.
- W2145402561 modified "2023-10-14" @default.
- W2145402561 title "Why chronic wounds will not heal: a novel hypothesis" @default.
- W2145402561 cites W1277182343 @default.
- W2145402561 cites W1531858717 @default.
- W2145402561 cites W1542204592 @default.
- W2145402561 cites W1567514429 @default.
- W2145402561 cites W1821097090 @default.
- W2145402561 cites W1910087083 @default.
- W2145402561 cites W1924335355 @default.
- W2145402561 cites W1967432655 @default.
- W2145402561 cites W1969426309 @default.
- W2145402561 cites W1977778762 @default.
- W2145402561 cites W1981464009 @default.
- W2145402561 cites W1982310237 @default.
- W2145402561 cites W1985035909 @default.
- W2145402561 cites W1985598587 @default.
- W2145402561 cites W1987815733 @default.
- W2145402561 cites W1990246424 @default.
- W2145402561 cites W1990659092 @default.
- W2145402561 cites W1994514340 @default.
- W2145402561 cites W1994937222 @default.
- W2145402561 cites W2000106451 @default.
- W2145402561 cites W2000930830 @default.
- W2145402561 cites W2002670516 @default.
- W2145402561 cites W2012825558 @default.
- W2145402561 cites W2023028948 @default.
- W2145402561 cites W2034595187 @default.
- W2145402561 cites W2035969879 @default.
- W2145402561 cites W2041152068 @default.
- W2145402561 cites W2043535514 @default.
- W2145402561 cites W2044357500 @default.
- W2145402561 cites W2048361935 @default.
- W2145402561 cites W2048602281 @default.
- W2145402561 cites W2049699258 @default.
- W2145402561 cites W2053460725 @default.
- W2145402561 cites W2056105632 @default.
- W2145402561 cites W2057055923 @default.
- W2145402561 cites W2061992885 @default.
- W2145402561 cites W2064612941 @default.
- W2145402561 cites W2068781163 @default.
- W2145402561 cites W2074853205 @default.
- W2145402561 cites W2079587426 @default.
- W2145402561 cites W2080525080 @default.
- W2145402561 cites W2080936059 @default.
- W2145402561 cites W2084796782 @default.
- W2145402561 cites W2085360512 @default.
- W2145402561 cites W2089310344 @default.
- W2145402561 cites W2097478029 @default.
- W2145402561 cites W2101270299 @default.
- W2145402561 cites W2102561895 @default.
- W2145402561 cites W2103780237 @default.
- W2145402561 cites W2104462602 @default.
- W2145402561 cites W2109942408 @default.
- W2145402561 cites W2113388925 @default.
- W2145402561 cites W2114671816 @default.
- W2145402561 cites W2115166015 @default.
- W2145402561 cites W2118023881 @default.
- W2145402561 cites W2118260061 @default.
- W2145402561 cites W2119410664 @default.
- W2145402561 cites W2122721391 @default.
- W2145402561 cites W2124031945 @default.
- W2145402561 cites W2124772160 @default.
- W2145402561 cites W2131903790 @default.
- W2145402561 cites W2132927585 @default.
- W2145402561 cites W2135998583 @default.
- W2145402561 cites W2141074420 @default.
- W2145402561 cites W2142319547 @default.
- W2145402561 cites W2142596421 @default.
- W2145402561 cites W2146058863 @default.
- W2145402561 cites W2146292204 @default.
- W2145402561 cites W2150417163 @default.
- W2145402561 cites W2150741646 @default.
- W2145402561 cites W2162427999 @default.
- W2145402561 cites W2163182389 @default.
- W2145402561 cites W2164955786 @default.
- W2145402561 cites W2165320241 @default.
- W2145402561 cites W2165707370 @default.
- W2145402561 cites W2166421183 @default.
- W2145402561 cites W2166816492 @default.
- W2145402561 cites W4213354399 @default.
- W2145402561 cites W4246241505 @default.
- W2145402561 cites W4301419429 @default.
- W2145402561 cites W85901280 @default.
- W2145402561 doi "https://doi.org/10.1111/j.1524-475x.2007.00283.x" @default.
- W2145402561 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18211573" @default.
- W2145402561 hasPublicationYear "2007" @default.
- W2145402561 type Work @default.