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• W2145403417 startingPage "1223" @default.
• W2145403417 abstract "Transient receptor potential channel V4 (TRPV4) functions as a nonselective cation channel in various cells and plays physiological roles in osmotic and thermal sensation. However, the function of TRPV4 in energy metabolism is unknown. Here, we report that TRPV4 deficiency results in increased muscle oxidative capacity and resistance to diet-induced obesity in mice. Although no difference in body weight was observed between wild-type and Trpv4 −/− mice when fed a standard chow diet, obesity phenotypes induced by a high-fat diet were significantly improved in Trpv4 −/− mice, without any change in food intake. Quantitative analysis of mRNA revealed the constitutive upregulation of many genes, including those for transcription factors such as peroxisome proliferator-activated receptor α and for metabolic enzymes such as phosphoenolpyruvate carboxykinase. These upregulated genes were especially prominent in oxidative skeletal muscle, in which the activity of Ca 2+ -dependent phosphatase calcineurin was elevated, suggesting that other Ca 2+ channels function in the skeletal muscle of Trpv4 −/− mice. Indeed, gene expressions for TRPC3 and TRPC6 increased in the muscles of Trpv4 −/− mice compared with those of wild-type mice. The number of oxidative type I fiber also increased in the mutant muscles following myogenin gene induction. These results strongly suggested that inactivation of Trpv4 induces compensatory increases in TRPC3 and TRPC6 production, and elevation of calcineurin activity, affecting energy metabolism through increased expression of genes involved in fuel oxidation in skeletal muscle and thereby contributing to increased energy expenditure and protection from diet-induced obesity in mice." @default.
• W2145403417 created "2016-06-24" @default.
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• W2145403417 creator A5081577782 @default.
• W2145403417 creator A5085721249 @default.
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• W2145403417 date "2012-04-01" @default.
• W2145403417 modified "2023-09-25" @default.
• W2145403417 title "TRPV4 deficiency increases skeletal muscle metabolic capacity and resistance against diet-induced obesity" @default.
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• W2145403417 cites W1966740493 @default.
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• W2145403417 doi "https://doi.org/10.1152/japplphysiol.01070.2011" @default.
• W2145403417 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22207724" @default.
• W2145403417 hasPublicationYear "2012" @default.
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