Matches in SemOpenAlex for { <https://semopenalex.org/work/W2145414904> ?p ?o ?g. }
- W2145414904 endingPage "808" @default.
- W2145414904 startingPage "800" @default.
- W2145414904 abstract "Elevations in systemic free fatty acids (FFA) contribute to insulin resistance. To determine the effects of an acute elevation in FFA on insulin action with aging, we infused saline or intralipid (IL) during a hyperinsulinemic–euglycemic clamp in three groups of rats: young ad libitum–fed (YAL), old ad libitum–fed (OAL), and old on lifelong calorie restriction (OCR). The OCR group was included to distinguish between aging per se and age-related changes in body fat distribution. IL induced marked insulin resistance in both YAL and OCR, but the onset of insulin resistance was approximately two to three times more rapid in OCR as compared with YAL. In response to IL infusion, plasminogen-activating inhibitor-1 (PAI-1) expression was increased in subcutaneous fat from OAL animals. In visceral fat, a marked increase in PAI-1 and interleukin-6 expression was observed in OAL and OCR rats, but not YAL, in response to IL treatment. Thus, aging per se increases the inflammatory response to excess nutrients and vulnerability to FFA-induced insulin resistance with aging." @default.
- W2145414904 created "2016-06-24" @default.
- W2145414904 creator A5002207908 @default.
- W2145414904 creator A5035765034 @default.
- W2145414904 creator A5047950133 @default.
- W2145414904 creator A5055979731 @default.
- W2145414904 creator A5065778332 @default.
- W2145414904 creator A5066248911 @default.
- W2145414904 creator A5075346656 @default.
- W2145414904 creator A5081960135 @default.
- W2145414904 creator A5083840207 @default.
- W2145414904 date "2010-05-26" @default.
- W2145414904 modified "2023-10-02" @default.
- W2145414904 title "Aging per se Increases the Susceptibility to Free Fatty Acid-Induced Insulin Resistance" @default.
- W2145414904 cites W1971412377 @default.
- W2145414904 cites W1974834425 @default.
- W2145414904 cites W1983854928 @default.
- W2145414904 cites W1989897184 @default.
- W2145414904 cites W1999971397 @default.
- W2145414904 cites W2010417927 @default.
- W2145414904 cites W2012898950 @default.
- W2145414904 cites W2014141074 @default.
- W2145414904 cites W2014671368 @default.
- W2145414904 cites W2016070194 @default.
- W2145414904 cites W2028944015 @default.
- W2145414904 cites W2037526260 @default.
- W2145414904 cites W2040808476 @default.
- W2145414904 cites W2041909478 @default.
- W2145414904 cites W2045601200 @default.
- W2145414904 cites W2049607896 @default.
- W2145414904 cites W2053982294 @default.
- W2145414904 cites W2059842910 @default.
- W2145414904 cites W2061570884 @default.
- W2145414904 cites W2070100445 @default.
- W2145414904 cites W2079978386 @default.
- W2145414904 cites W2082168176 @default.
- W2145414904 cites W2092404576 @default.
- W2145414904 cites W2096587251 @default.
- W2145414904 cites W2106650290 @default.
- W2145414904 cites W2107146209 @default.
- W2145414904 cites W2113283200 @default.
- W2145414904 cites W2113570850 @default.
- W2145414904 cites W2128151093 @default.
- W2145414904 cites W2128529644 @default.
- W2145414904 cites W2130850001 @default.
- W2145414904 cites W2146845495 @default.
- W2145414904 cites W2148713009 @default.
- W2145414904 cites W2156280702 @default.
- W2145414904 cites W2165826818 @default.
- W2145414904 cites W2170651583 @default.
- W2145414904 cites W2412869619 @default.
- W2145414904 cites W3145786645 @default.
- W2145414904 cites W4241211373 @default.
- W2145414904 cites W4249727000 @default.
- W2145414904 doi "https://doi.org/10.1093/gerona/glq078" @default.
- W2145414904 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2903785" @default.
- W2145414904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20504893" @default.
- W2145414904 hasPublicationYear "2010" @default.
- W2145414904 type Work @default.
- W2145414904 sameAs 2145414904 @default.
- W2145414904 citedByCount "39" @default.
- W2145414904 countsByYear W21454149042012 @default.
- W2145414904 countsByYear W21454149042013 @default.
- W2145414904 countsByYear W21454149042014 @default.
- W2145414904 countsByYear W21454149042015 @default.
- W2145414904 countsByYear W21454149042016 @default.
- W2145414904 countsByYear W21454149042017 @default.
- W2145414904 countsByYear W21454149042018 @default.
- W2145414904 countsByYear W21454149042020 @default.
- W2145414904 countsByYear W21454149042021 @default.
- W2145414904 countsByYear W21454149042022 @default.
- W2145414904 countsByYear W21454149042023 @default.
- W2145414904 crossrefType "journal-article" @default.
- W2145414904 hasAuthorship W2145414904A5002207908 @default.
- W2145414904 hasAuthorship W2145414904A5035765034 @default.
- W2145414904 hasAuthorship W2145414904A5047950133 @default.
- W2145414904 hasAuthorship W2145414904A5055979731 @default.
- W2145414904 hasAuthorship W2145414904A5065778332 @default.
- W2145414904 hasAuthorship W2145414904A5066248911 @default.
- W2145414904 hasAuthorship W2145414904A5075346656 @default.
- W2145414904 hasAuthorship W2145414904A5081960135 @default.
- W2145414904 hasAuthorship W2145414904A5083840207 @default.
- W2145414904 hasBestOaLocation W21454149041 @default.
- W2145414904 hasConcept C126322002 @default.
- W2145414904 hasConcept C134018914 @default.
- W2145414904 hasConcept C2777391703 @default.
- W2145414904 hasConcept C2777397205 @default.
- W2145414904 hasConcept C2778707264 @default.
- W2145414904 hasConcept C2778808658 @default.
- W2145414904 hasConcept C2779306644 @default.
- W2145414904 hasConcept C2780352109 @default.
- W2145414904 hasConcept C543025807 @default.
- W2145414904 hasConcept C55493867 @default.
- W2145414904 hasConcept C71924100 @default.
- W2145414904 hasConcept C86803240 @default.
- W2145414904 hasConceptScore W2145414904C126322002 @default.
- W2145414904 hasConceptScore W2145414904C134018914 @default.
- W2145414904 hasConceptScore W2145414904C2777391703 @default.