FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2145420627> ?p ?o ?g. }

• W2145420627 abstract "Malaria remains a burden in Sub-Saharan Countries. The strategy proposed by the World Health Organization (WHO) is to systematically compare the therapeutic efficacy of antimalarial drugs using as primary outcome for efficacy, a four-category ordered criterion. The objective of the present work was to analyze the treatment effects on this primary outcome taking into account both a center-effect and individual covariates. A three-arm, three-centre trial of Amodiaquine (AQ), sulfadoxine-pyrimethamine (SP) and their combination (AQ + SP), conducted by OCEAC-IRD in 2003, in 538 children with uncomplicated Plasmodium falciparum malaria, is used as an illustration. Analyses were based on ordinal regression methods, assuming an underlying continuous latent variable, using either the proportional odds (PO) or the proportional hazards (PH) models. Different algorithms, corresponding to both frequentist- and bayesian-approaches, were implemented using the freely available softwares R and Winbugs, respectively. The performances of the different methods were evaluated on a simulated data set, and then they were applied on the trial data set. Good coverage probability and type-1 error for the treatment effect were achieved. When the methods were applied on the trial data set, results highlighted a significance decrease of SP efficacy when compared to AQ (PO, odds ratio [OR] 0.14, 95% confidence interval [CI] 0.04-0.57; hazard ratio [HR] 0.605, 95% CI 0.42-0.82), and an equal effectiveness between AQ + SP and AQ (PO, odds ratio [OR] 1.70, 95% confidence interval [CI] 0.25-11.44; hazard ratio [HR] 1.40, 95% CI 0.88-2.18). The body temperature was significantly related to the responses. The patient weights were marginally associated to the clinical response. The proposed analyses, based on usual statistical packages, appeared adapted to take into account the full information contained in the four categorical outcome in malaria trials, as defined by WHO, with the possibility of adjusting on individual and global covariates." @default.
• W2145420627 created "2016-06-24" @default.
• W2145420627 creator A5002399237 @default.
• W2145420627 creator A5024474269 @default.
• W2145420627 creator A5062154496 @default.
• W2145420627 creator A5065237250 @default.
• W2145420627 date "2010-06-18" @default.
• W2145420627 modified "2023-10-09" @default.
• W2145420627 title "Analysis of an ordinal outcome in a multicentric randomized controlled trial: application to a 3- arm anti- malarial drug trial in Cameroon" @default.
• W2145420627 cites W1945827446 @default.
• W2145420627 cites W1972148175 @default.
• W2145420627 cites W1981457286 @default.
• W2145420627 cites W1982265233 @default.
• W2145420627 cites W1994463643 @default.
• W2145420627 cites W2005771735 @default.
• W2145420627 cites W2016954998 @default.
• W2145420627 cites W2036180391 @default.
• W2145420627 cites W2048834380 @default.
• W2145420627 cites W2050482415 @default.
• W2145420627 cites W2066457477 @default.
• W2145420627 cites W2076983043 @default.
• W2145420627 cites W2097260567 @default.
• W2145420627 cites W2100802288 @default.
• W2145420627 cites W2104392429 @default.
• W2145420627 cites W2106374162 @default.
• W2145420627 cites W2108512502 @default.
• W2145420627 cites W2130028379 @default.
• W2145420627 cites W2136579540 @default.
• W2145420627 cites W2155517825 @default.
• W2145420627 cites W2161147823 @default.
• W2145420627 cites W2165389311 @default.
• W2145420627 cites W2171426733 @default.
• W2145420627 cites W2184013387 @default.
• W2145420627 cites W3175417087 @default.
• W2145420627 cites W4292024691 @default.
• W2145420627 doi "https://doi.org/10.1186/1471-2288-10-58" @default.
• W2145420627 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2908105" @default.
• W2145420627 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20565837" @default.
• W2145420627 hasPublicationYear "2010" @default.
• W2145420627 type Work @default.
• W2145420627 sameAs 2145420627 @default.
• W2145420627 citedByCount "4" @default.
• W2145420627 countsByYear W21454206272012 @default.
• W2145420627 countsByYear W21454206272014 @default.
• W2145420627 countsByYear W21454206272020 @default.
• W2145420627 countsByYear W21454206272021 @default.
• W2145420627 crossrefType "journal-article" @default.
• W2145420627 hasAuthorship W2145420627A5002399237 @default.
• W2145420627 hasAuthorship W2145420627A5024474269 @default.
• W2145420627 hasAuthorship W2145420627A5062154496 @default.
• W2145420627 hasAuthorship W2145420627A5065237250 @default.
• W2145420627 hasBestOaLocation W21454206271 @default.
• W2145420627 hasConcept C105795698 @default.
• W2145420627 hasConcept C107673813 @default.
• W2145420627 hasConcept C119043178 @default.
• W2145420627 hasConcept C126322002 @default.
• W2145420627 hasConcept C156957248 @default.
• W2145420627 hasConcept C160234255 @default.
• W2145420627 hasConcept C162376815 @default.
• W2145420627 hasConcept C203014093 @default.
• W2145420627 hasConcept C207103383 @default.
• W2145420627 hasConcept C2776992834 @default.
• W2145420627 hasConcept C2777035104 @default.
• W2145420627 hasConcept C2778048844 @default.
• W2145420627 hasConcept C2778371730 @default.
• W2145420627 hasConcept C2780441369 @default.
• W2145420627 hasConcept C33923547 @default.
• W2145420627 hasConcept C44249647 @default.
• W2145420627 hasConcept C71924100 @default.
• W2145420627 hasConceptScore W2145420627C105795698 @default.
• W2145420627 hasConceptScore W2145420627C107673813 @default.
• W2145420627 hasConceptScore W2145420627C119043178 @default.
• W2145420627 hasConceptScore W2145420627C126322002 @default.
• W2145420627 hasConceptScore W2145420627C156957248 @default.
• W2145420627 hasConceptScore W2145420627C160234255 @default.
• W2145420627 hasConceptScore W2145420627C162376815 @default.
• W2145420627 hasConceptScore W2145420627C203014093 @default.
• W2145420627 hasConceptScore W2145420627C207103383 @default.
• W2145420627 hasConceptScore W2145420627C2776992834 @default.
• W2145420627 hasConceptScore W2145420627C2777035104 @default.
• W2145420627 hasConceptScore W2145420627C2778048844 @default.
• W2145420627 hasConceptScore W2145420627C2778371730 @default.
• W2145420627 hasConceptScore W2145420627C2780441369 @default.
• W2145420627 hasConceptScore W2145420627C33923547 @default.
• W2145420627 hasConceptScore W2145420627C44249647 @default.
• W2145420627 hasConceptScore W2145420627C71924100 @default.
• W2145420627 hasIssue "1" @default.
• W2145420627 hasLocation W21454206271 @default.
• W2145420627 hasLocation W21454206272 @default.
• W2145420627 hasLocation W21454206273 @default.
• W2145420627 hasLocation W21454206274 @default.
• W2145420627 hasLocation W21454206275 @default.
• W2145420627 hasLocation W21454206276 @default.
• W2145420627 hasOpenAccess W2145420627 @default.
• W2145420627 hasPrimaryLocation W21454206271 @default.
• W2145420627 hasRelatedWork W1737756073 @default.
• W2145420627 hasRelatedWork W2010392647 @default.
• W2145420627 hasRelatedWork W2072196024 @default.
• W2145420627 hasRelatedWork W2145420627 @default.
• W2145420627 hasRelatedWork W2417810012 @default.

• next