FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2145440239> ?p ?o ?g. }

• W2145440239 endingPage "1113" @default.
• W2145440239 startingPage "1100" @default.
• W2145440239 abstract "ABSTRACT Cryptococcus neoformans var. grubii is the most frequent cause of AIDS-associated cryptococcosis worldwide, while Cryptococcus gattii usually infects immunocompetent people. To understand the mechanisms which cause differential susceptibility to these cryptococcal species in HIV infection, we established and characterized a model of cryptococcosis in CD4C/HIV MutA transgenic (Tg) mice expressing gene products of HIV-1 and developing an AIDS-like disease. Tg mice infected intranasally with C. neoformans var. grubii strain H99 or C23 consistently displayed reduced survival compared to non-Tg mice at three graded inocula, while shortened survival of Tg mice infected with C. gattii strain R265 or R272 was restricted to a single high inoculum. HIV-1 transgene expression selectively augmented systemic dissemination to the liver and spleen for strains H99 and C23 but not strains R265 and R272. Histopathologic examination of lungs of Tg mice revealed large numbers of widely scattered H99 cells, with a minimal inflammatory cell response, while in the non-Tg mice H99 was almost completely embedded within extensive mixed inflammatory cell infiltrates. In contrast to H99, R265 was dispersed throughout the lung parenchyma and failed to induce a strong inflammatory response in both Tg and non-Tg mice. HIV-1 transgene expression reduced pulmonary production of CCL2 and CCL5 after infection with H99 or R265, and production of these two chemokines was lower after infection with R265. These results indicate that an altered immune response in these Tg mice markedly enhances C. neoformans but not C. gattii infection. This model therefore provides a powerful new tool to further investigate the immunopathogenesis of cryptococcosis." @default.
• W2145440239 created "2016-06-24" @default.
• W2145440239 creator A5028223018 @default.
• W2145440239 creator A5033642835 @default.
• W2145440239 creator A5046516066 @default.
• W2145440239 creator A5054202390 @default.
• W2145440239 creator A5060855573 @default.
• W2145440239 creator A5066649593 @default.
• W2145440239 creator A5069590816 @default.
• W2145440239 creator A5069854102 @default.
• W2145440239 creator A5082333058 @default.
• W2145440239 date "2013-01-22" @default.
• W2145440239 modified "2023-10-03" @default.
• W2145440239 title "Altered Immune Response Differentially Enhances Susceptibility to Cryptococcus neoformans and Cryptococcus gattii Infection in Mice Expressing the HIV-1 Transgene" @default.
• W2145440239 cites W1539825474 @default.
• W2145440239 cites W1542277406 @default.
• W2145440239 cites W1549028085 @default.
• W2145440239 cites W1566927595 @default.
• W2145440239 cites W1585461212 @default.
• W2145440239 cites W1874688038 @default.
• W2145440239 cites W1896668130 @default.
• W2145440239 cites W1912169188 @default.
• W2145440239 cites W1923814307 @default.
• W2145440239 cites W1939001682 @default.
• W2145440239 cites W1943990936 @default.
• W2145440239 cites W1970025115 @default.
• W2145440239 cites W1981767047 @default.
• W2145440239 cites W1983947294 @default.
• W2145440239 cites W1986170080 @default.
• W2145440239 cites W1988759080 @default.
• W2145440239 cites W1995414452 @default.
• W2145440239 cites W1997902540 @default.
• W2145440239 cites W1998933515 @default.
• W2145440239 cites W2004173797 @default.
• W2145440239 cites W2009157855 @default.
• W2145440239 cites W2016723478 @default.
• W2145440239 cites W2018552263 @default.
• W2145440239 cites W2024248233 @default.
• W2145440239 cites W2027890910 @default.
• W2145440239 cites W2031528938 @default.
• W2145440239 cites W2043520974 @default.
• W2145440239 cites W2044273291 @default.
• W2145440239 cites W2054000111 @default.
• W2145440239 cites W2055416073 @default.
• W2145440239 cites W2056573634 @default.
• W2145440239 cites W2060197485 @default.
• W2145440239 cites W2060646786 @default.
• W2145440239 cites W2079242559 @default.
• W2145440239 cites W2079513681 @default.
• W2145440239 cites W2092024253 @default.
• W2145440239 cites W2095601290 @default.
• W2145440239 cites W2096038565 @default.
• W2145440239 cites W2100246023 @default.
• W2145440239 cites W2103088765 @default.
• W2145440239 cites W2112675507 @default.
• W2145440239 cites W2114445049 @default.
• W2145440239 cites W2115408128 @default.
• W2145440239 cites W2116355322 @default.
• W2145440239 cites W2122664093 @default.
• W2145440239 cites W2124041958 @default.
• W2145440239 cites W2125274770 @default.
• W2145440239 cites W2128546265 @default.
• W2145440239 cites W2129708180 @default.
• W2145440239 cites W2134900294 @default.
• W2145440239 cites W2137596136 @default.
• W2145440239 cites W2139842783 @default.
• W2145440239 cites W2142893865 @default.
• W2145440239 cites W2143253741 @default.
• W2145440239 cites W2143616661 @default.
• W2145440239 cites W2146171603 @default.
• W2145440239 cites W2150996587 @default.
• W2145440239 cites W2153040975 @default.
• W2145440239 cites W2155068496 @default.
• W2145440239 cites W2161004182 @default.
• W2145440239 cites W2162644900 @default.
• W2145440239 cites W2163540334 @default.
• W2145440239 cites W2163860604 @default.
• W2145440239 cites W2163891017 @default.
• W2145440239 cites W2165821599 @default.
• W2145440239 cites W2166123227 @default.
• W2145440239 cites W2167147506 @default.
• W2145440239 cites W2169688500 @default.
• W2145440239 cites W2172207388 @default.
• W2145440239 cites W4235842780 @default.
• W2145440239 doi "https://doi.org/10.1128/iai.01339-12" @default.
• W2145440239 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3639619" @default.
• W2145440239 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23340313" @default.
• W2145440239 hasPublicationYear "2013" @default.
• W2145440239 type Work @default.
• W2145440239 sameAs 2145440239 @default.
• W2145440239 citedByCount "11" @default.
• W2145440239 countsByYear W21454402392014 @default.
• W2145440239 countsByYear W21454402392015 @default.
• W2145440239 countsByYear W21454402392016 @default.
• W2145440239 countsByYear W21454402392017 @default.
• W2145440239 countsByYear W21454402392018 @default.
• W2145440239 countsByYear W21454402392019 @default.
• W2145440239 countsByYear W21454402392020 @default.

• next