FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2145447211> ?p ?o ?g. }

• W2145447211 endingPage "1028" @default.
• W2145447211 startingPage "1023" @default.
• W2145447211 abstract "A variant of human immunodeficiency virus type 1 (HIV-1) possessing a deletion in the reverse transcriptase (RT) gene at codon 67 was identified in a patient who had failed combination antiretroviral therapy. This deletion initially emerged under the selective pressure of combination therapy with 3'-azido-3'-deoxythymidine (AZT) plus 2',3'-dideoxyinosine. It has persisted for more than 3 years in association with the accumulation of a variety of other well-described drug resistance mutations and an uncharacterized mutation at RT codon 69 (T69G). Phenotypic studies demonstrated that the codon 67 deletion by itself had little effect on AZT sensitivity. However, in the context of the T69G mutation and three other mutations known to be associated with AZT resistance (K70R, T215F, and K219Q), this deletion led to a increase in AZT resistance from 8. 5-fold to 445-fold. A further increase in resistance (up to 1, 813-fold) was observed when two mutations associated with nonnucleoside RT inhibitor resistance (K103N and L74I) were added to the deletion T69G K70R T215F K219Q construct. Hence, these results establish that a deletion at RT codon 67 may be selected for in the presence of antiretroviral therapy and may lead to high-level resistance to AZT." @default.
• W2145447211 created "2016-06-24" @default.
• W2145447211 creator A5009813178 @default.
• W2145447211 creator A5017141290 @default.
• W2145447211 creator A5030398856 @default.
• W2145447211 creator A5039365082 @default.
• W2145447211 creator A5043417594 @default.
• W2145447211 creator A5058143327 @default.
• W2145447211 creator A5067339150 @default.
• W2145447211 date "2000-01-15" @default.
• W2145447211 modified "2023-10-16" @default.
• W2145447211 title "High-Level Resistance to 3′-Azido-3′-Deoxythimidine due to a Deletion in the Reverse Transcriptase Gene of Human Immunodeficiency Virus Type 1" @default.
• W2145447211 cites W1576999979 @default.
• W2145447211 cites W1608628964 @default.
• W2145447211 cites W1659719610 @default.
• W2145447211 cites W1735143085 @default.
• W2145447211 cites W1867254541 @default.
• W2145447211 cites W1895373002 @default.
• W2145447211 cites W1921702285 @default.
• W2145447211 cites W1966952510 @default.
• W2145447211 cites W1968896603 @default.
• W2145447211 cites W1973711348 @default.
• W2145447211 cites W1981912838 @default.
• W2145447211 cites W1989041073 @default.
• W2145447211 cites W1989692384 @default.
• W2145447211 cites W2005607027 @default.
• W2145447211 cites W2008383946 @default.
• W2145447211 cites W2008428638 @default.
• W2145447211 cites W2015326137 @default.
• W2145447211 cites W2020760853 @default.
• W2145447211 cites W2025693221 @default.
• W2145447211 cites W2025994885 @default.
• W2145447211 cites W2032026161 @default.
• W2145447211 cites W2033939669 @default.
• W2145447211 cites W2044435291 @default.
• W2145447211 cites W2046134251 @default.
• W2145447211 cites W2056686421 @default.
• W2145447211 cites W2057387869 @default.
• W2145447211 cites W2060829964 @default.
• W2145447211 cites W2063785972 @default.
• W2145447211 cites W2064945443 @default.
• W2145447211 cites W2069572775 @default.
• W2145447211 cites W2071313281 @default.
• W2145447211 cites W2074495023 @default.
• W2145447211 cites W2086462809 @default.
• W2145447211 cites W2090646713 @default.
• W2145447211 cites W2106371912 @default.
• W2145447211 cites W2117940098 @default.
• W2145447211 cites W2119181700 @default.
• W2145447211 cites W2120830682 @default.
• W2145447211 cites W2127923731 @default.
• W2145447211 cites W2129048881 @default.
• W2145447211 cites W2132185205 @default.
• W2145447211 cites W2136674566 @default.
• W2145447211 cites W2139250164 @default.
• W2145447211 cites W2142577196 @default.
• W2145447211 cites W2156987878 @default.
• W2145447211 cites W2161558889 @default.
• W2145447211 cites W2231831983 @default.
• W2145447211 cites W2318289184 @default.
• W2145447211 cites W2589649603 @default.
• W2145447211 doi "https://doi.org/10.1128/jvi.74.2.1023-1028.2000" @default.
• W2145447211 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/111626" @default.
• W2145447211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10623768" @default.
• W2145447211 hasPublicationYear "2000" @default.
• W2145447211 type Work @default.
• W2145447211 sameAs 2145447211 @default.
• W2145447211 citedByCount "40" @default.
• W2145447211 countsByYear W21454472112013 @default.
• W2145447211 countsByYear W21454472112015 @default.
• W2145447211 countsByYear W21454472112016 @default.
• W2145447211 crossrefType "journal-article" @default.
• W2145447211 hasAuthorship W2145447211A5009813178 @default.
• W2145447211 hasAuthorship W2145447211A5017141290 @default.
• W2145447211 hasAuthorship W2145447211A5030398856 @default.
• W2145447211 hasAuthorship W2145447211A5039365082 @default.
• W2145447211 hasAuthorship W2145447211A5043417594 @default.
• W2145447211 hasAuthorship W2145447211A5058143327 @default.
• W2145447211 hasAuthorship W2145447211A5067339150 @default.
• W2145447211 hasBestOaLocation W21454472112 @default.
• W2145447211 hasConcept C104317684 @default.
• W2145447211 hasConcept C114851261 @default.
• W2145447211 hasConcept C151730666 @default.
• W2145447211 hasConcept C156719811 @default.
• W2145447211 hasConcept C159047783 @default.
• W2145447211 hasConcept C182707283 @default.
• W2145447211 hasConcept C20580545 @default.
• W2145447211 hasConcept C2522874641 @default.
• W2145447211 hasConcept C2779343474 @default.
• W2145447211 hasConcept C2780216070 @default.
• W2145447211 hasConcept C2780727368 @default.
• W2145447211 hasConcept C501734568 @default.
• W2145447211 hasConcept C54355233 @default.
• W2145447211 hasConcept C67705224 @default.
• W2145447211 hasConcept C86803240 @default.
• W2145447211 hasConceptScore W2145447211C104317684 @default.
• W2145447211 hasConceptScore W2145447211C114851261 @default.
• W2145447211 hasConceptScore W2145447211C151730666 @default.

• next