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- W2145451127 abstract "1. [14C]Minaprine was administered as a single oral dose to five animal species and to a healthy and informed volunteer. Excretion of radioactivity was followed during 48 h in urine and faces; biliary excretion was followed only in rat. 2. Urinary metabolites were isolated and identified by mass spectrometry. 3. A quantitative comparison of metabolites in different species was made. On the basis of these data it it concluded that the dog is not a suitable model for man for pharmacological or toxicological studies. 4. The major metabolic route is 4-hydroxylation of the aromatic ring. The only unexpected metabolic route found was the biotransformation of the morpholino ring, probably by reductive ring-cleavage. 5. About 50% of the 14C was excreted in 0-48 h urine. The other 50% was excreted in the 0-48 h faces. In the rat, this was attribute entirely to biliary excretion. The drug is well absorbed after oral administration and is not accumulated in the body." @default.
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- W2145451127 date "1981-01-01" @default.
- W2145451127 modified "2023-09-25" @default.
- W2145451127 title "The biotransformation of [14C]minaprine in man and five animal species" @default.
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- W2145451127 doi "https://doi.org/10.3109/00498258109045877" @default.
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