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- W2145456435 abstract "Background: Severe asthma and chronic rhino-sinusitis often coexist (Meltzer, JACI 2004). Patients with severe asthma have shown to benefit from high altitude treatment (Rijssenbeek AJRCCM 2010). It is unknown whether chronic rhino-sinusitis also improves at high altitude. Aim: To investigate the effect of high altitude treatment on symptoms of upper and lower airways disease in patients with severe asthma and rhino-sinusitis. Methods: 137 patients with severe asthma treated at the Dutch Asthmacenter Davos were included. In 65 patients, using nasal steroids, sino-nasal symptoms (SNOT scores), asthma control (ACQ), exhaled Nitric Oxide (FeNO), use of oral and nasal steroids were analysed, as well as the relationship between parameters of upper and lower airways. Parametric and non-parametric tests were used where appropriate. The improvement in SNOT-20 correlated significantly with the improvement in ACQ (R=0.527, p Conclusions: A simultaneous improvement in upper and lower airway symptoms and oral steroid use occurs at high altitude in patients with severe asthma and chronic rhino-sinusitis. Implications: These beneficial effects on upper airways disease underscore the anti-inflammatory and steroid-sparing effect of high altitude treatment in patients with severe asthma." @default.
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- W2145456435 date "2011-09-01" @default.
- W2145456435 modified "2023-09-28" @default.
- W2145456435 title "Chronic rhino-sinusitis in severe asthma improves at high altitude" @default.
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