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- W2145466954 abstract "We have previously shown that periadventitial delivery of nitric oxide (NO) after arterial injury prevents the development of neointimal hyperplasia; however, the durability of NO-based therapies is unknown. We hypothesize that the effect of NO is durable and due to alteration of cell populations within the arterial wall. The carotid artery balloon injury model was performed on Sprague Dawley rats. Treatment groups included Injury (I) or I+PROLI/NO (20mg). Arteries were harvested at 2 and 8 wks. Neointimal hyperplasia was quantified morphometrically. Van Gieson stain assessed collagen content. Immunohistochemical staining for αSMC actin and desmin assessed smooth muscle cell (SMC) and fibroblast phenotype. NO reduced intimal area (90 and 95%, p < 0.001), medial area (46 and 47%, p < 0.001), and intima/media area ratio (82 and 69%, p < 0.001) at 2 and 8 wks, respectively, with no statistical difference between time points. Qualitatively, NO decreased collagen content compared to I alone. NO reduced total cell number in the arterial wall at 2 and 8 wks (51 and 42%, resp., p < 0.001) by decreasing cell number in the intima (85%, p < 0.001) and media (93%, p < 0.001), but not the adventitia. In fact, adventitial cell count was greater in NO-treated arteries compared to I alone (39% and 54% at 2 and 8 wks, p < 0.001). At 8 wks, an increase in cell number was observed in the adventitia (9%) and media (85%) in the NO-treated arteries compared to the I alone arteries, which was stable. Lastly, SMC markers αSMC actin and desmin were decreased at 2 and 8 wks in NO-treated arteries compared to I alone (52 and 70%, resp., p≤0.009), but this effect was limited to the intima and media. Periadventitial delivery of NO results in durable inhibition of neointimal hyperplasia. Our data suggest that NO reduces collagen content, inhibits repopulation of the media, and inhibits migration of adventitial cells to the intima and media after arterial injury." @default.
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- W2145466954 date "2010-06-01" @default.
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- W2145466954 title "PS202. Durable Effect of Nitric Oxide at Inhibiting Neointimal Hyperplasia Is due to Modulation of Cellular Populations Throughout the Arterial Wall" @default.
- W2145466954 doi "https://doi.org/10.1016/j.jvs.2010.02.187" @default.
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