FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2145485149> ?p ?o ?g. }

• W2145485149 abstract "Radiotherapy (RT) is an important tool in the multidisciplinary management of breast cancer. The Early Breast Cancer Trialists’ Collaborative Group (EBCTCG) meta-analysis of randomised clinical trials demonstrated that the addition of RT to breast cancer therapy resulted in a significant reduction in the risk of local breast cancer recurrence, leading to a reduction in the risk of mortality. For every four local recurrences avoided by RT in years 1–5, about one death from breast cancer was avoided by year 15 [1]. However, when targeting the breast/chest wall with RT, some radiation is also delivered to the underlying normal tissues (e.g. heart and lung), and RT has been associated with an increased risk of late onset cardiotoxicity and second malignancies. In the EBCTCG analysis there was a significant excess of fatal heart disease (rate ratio 1.27, standard error (SE) 0.07, P = 0.0001) among irradiated women. Similarly, an excess incidence of second lung cancer (rate ratio 1.61, SE 0.18, P = 0.0007) and lung cancer deaths (rate ratio 1.78, SE 0.22, P = 0.0004) was found for irradiated patients. These long term side effects tend to offset the beneficial effect of RT. For example, in the meta-analysis, overall survival remained significantly improved for women given breast conserving surgery and for women with node-positive disease treated with mastectomy and axillary clearance, but for women with node-negative disease treated with mastectomy and axillary clearance, the beneficial effect of RT on breast cancer survival was very small and the toxic side effects outweighed it. The amount of incidental radiation delivered to the underlying heart is greater with left-sided versus right-sided RT. Similarly, the amount of incidental lung irradiation will generally be greater for the ipsilateral versus contralateral lung. These differences in exposure have been used to evaluate the risk of cardiac disease and second lung cancer associated with RT. Among women diagnosed with breast cancer during 1973–1982 in US SEER cancer registries, an excess cardiac mortality (ratio of 1.42 (1.11−1.82)) for left-side irradiated patients, and excess lung cancer mortality (ratio of 2.00 (1.00–4.00)) for ipsilateral lung cancer at 10–14 years after RT was found [2]. These excess risks increased significantly and progressively with time since RT: cardiac mortality 1.58 (1.29–1.95) and ipsilateral lung cancer mortality 2.71 (1.65–4.48) at 15 years or more after RT. The risk of late radiation-associated sequelae with modern cancer treatment is uncertain, because older radiotherapy regimens resulted in larger cardiac dosevolume distributions to organs at risk than what is common with modern radiation techniques [3,4]. Nearly all of the above mentioned studies analysed data from an era before the routine use of threedimensional (3-D) simulation and planning, which allows for more accurate delineation of irradiated heart and lung volumes. Coincident with improvements in RT techniques, there have been observations of decreased incidence of radiation-associated sequelae over time [2,5]. Current research in this area is attempting to define more precisely the risk of radiation-associated sequelae and to deliver RT with improved sparing of organs at risk. A case-control study in Sweden and Denmark, Radiation-Associated Cardiovascular Events (RACE), is estimating irradiated cardiac volumes and correlating estimated cardiac dose with clinical events in an attempt to characterise the cardiac dose-response relationship [6]. Similarly, estimates of the mean ipsilateral lung RT dose have allowed for assessment of second lung cancer risk by RT dose. Two separate studies have reported an estimated increase in the relative risk for second lung cancer of approximately 0.1−0.2 per Gy (mean ipsilateral lung radiation dose) at 10 or more years after RT [7,8]. Other cancer treatment factors may also potentially increase the risk of late sequelae. Chemotherapeutic agents have changed over time, and newer agents such as anthracycline chemotherapy (doxorubicin and epirubicin) and immunotherapy (trastuzumab), which are themselves cardiotoxic, are increasingly being" @default.
• W2145485149 created "2016-06-24" @default.
• W2145485149 creator A5050578761 @default.
• W2145485149 creator A5077992903 @default.
• W2145485149 date "2009-09-01" @default.
• W2145485149 modified "2023-09-27" @default.
• W2145485149 title "Cardiac disease and second lung cancer after radiotherapy for breast cancer" @default.
• W2145485149 cites W1977270178 @default.
• W2145485149 cites W2016682611 @default.
• W2145485149 cites W2080448417 @default.
• W2145485149 cites W2140492419 @default.
• W2145485149 cites W2142397820 @default.
• W2145485149 cites W2151585080 @default.
• W2145485149 cites W2154214366 @default.
• W2145485149 cites W2158615473 @default.
• W2145485149 cites W2170368817 @default.
• W2145485149 doi "https://doi.org/10.1016/s0959-8049(09)70073-5" @default.
• W2145485149 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19775655" @default.
• W2145485149 hasPublicationYear "2009" @default.
• W2145485149 type Work @default.
• W2145485149 sameAs 2145485149 @default.
• W2145485149 citedByCount "3" @default.
• W2145485149 countsByYear W21454851492014 @default.
• W2145485149 countsByYear W21454851492015 @default.
• W2145485149 crossrefType "journal-article" @default.
• W2145485149 hasAuthorship W2145485149A5050578761 @default.
• W2145485149 hasAuthorship W2145485149A5077992903 @default.
• W2145485149 hasConcept C121608353 @default.
• W2145485149 hasConcept C126322002 @default.
• W2145485149 hasConcept C141071460 @default.
• W2145485149 hasConcept C143998085 @default.
• W2145485149 hasConcept C2776256026 @default.
• W2145485149 hasConcept C2776694085 @default.
• W2145485149 hasConcept C2777757722 @default.
• W2145485149 hasConcept C2778233292 @default.
• W2145485149 hasConcept C509974204 @default.
• W2145485149 hasConcept C530470458 @default.
• W2145485149 hasConcept C71924100 @default.
• W2145485149 hasConceptScore W2145485149C121608353 @default.
• W2145485149 hasConceptScore W2145485149C126322002 @default.
• W2145485149 hasConceptScore W2145485149C141071460 @default.
• W2145485149 hasConceptScore W2145485149C143998085 @default.
• W2145485149 hasConceptScore W2145485149C2776256026 @default.
• W2145485149 hasConceptScore W2145485149C2776694085 @default.
• W2145485149 hasConceptScore W2145485149C2777757722 @default.
• W2145485149 hasConceptScore W2145485149C2778233292 @default.
• W2145485149 hasConceptScore W2145485149C509974204 @default.
• W2145485149 hasConceptScore W2145485149C530470458 @default.
• W2145485149 hasConceptScore W2145485149C71924100 @default.
• W2145485149 hasLocation W21454851491 @default.
• W2145485149 hasLocation W21454851492 @default.
• W2145485149 hasOpenAccess W2145485149 @default.
• W2145485149 hasPrimaryLocation W21454851491 @default.
• W2145485149 hasRelatedWork W1975031316 @default.
• W2145485149 hasRelatedWork W2083849004 @default.
• W2145485149 hasRelatedWork W2130595789 @default.
• W2145485149 hasRelatedWork W2143888394 @default.
• W2145485149 hasRelatedWork W2408961867 @default.
• W2145485149 hasRelatedWork W2490583992 @default.
• W2145485149 hasRelatedWork W2513385871 @default.
• W2145485149 hasRelatedWork W2548698776 @default.
• W2145485149 hasRelatedWork W2743591021 @default.
• W2145485149 hasRelatedWork W2765538492 @default.
• W2145485149 hasRelatedWork W2901524150 @default.
• W2145485149 hasRelatedWork W2937757725 @default.
• W2145485149 hasRelatedWork W2988314950 @default.
• W2145485149 hasRelatedWork W2999849057 @default.
• W2145485149 hasRelatedWork W3013886098 @default.
• W2145485149 hasRelatedWork W3032047461 @default.
• W2145485149 hasRelatedWork W3038478885 @default.
• W2145485149 hasRelatedWork W3092495457 @default.
• W2145485149 hasRelatedWork W3092904777 @default.
• W2145485149 hasRelatedWork W583158932 @default.
• W2145485149 isParatext "false" @default.
• W2145485149 isRetracted "false" @default.
• W2145485149 magId "2145485149" @default.
• W2145485149 workType "article" @default.