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- W2145490184 abstract "Summary The immunogenicity of allogeneic cultured human epidermal keratinocytes (cHEKs) has been studied in several models with contradictory results. We studied human T‐cell activation in an in vitro assay by incubating, for 4 and 24 hr, cHEK confluent sheets with human peripheral blood mononuclear cells (PBMC); parallel HEK cultures were incubated with interferon (IFN)‐γ to induce the expression of major histocompatibility complex (MHC) molecules before their interaction with PBMC. T‐cell activation was evaluated by flow cytometry. T cells neither expressed the early and late activation markers CD69 and CD25, respectively, nor proliferated after incubation with the epidermal sheets, despite the IFN‐γ‐induced expression of MHC and adhesion molecules in cHEKs. Interleukin (IL)‐10 was detected in the medium from the co‐cultured PBMC and HEK sheets, but not from HEK alone. The results suggest that HEKs are unable to stimulate T lymphocytes through secretion of cytokines that might contribute to the immunosuppressive effect in this in vitro model." @default.
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- W2145490184 date "2008-10-08" @default.
- W2145490184 modified "2023-10-16" @default.
- W2145490184 title "Epidermal keratinocytes do not activate peripheral T-cells: interleukin-10 as a possible regulator" @default.
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- W2145490184 doi "https://doi.org/10.1111/j.1365-2567.2008.02859.x" @default.
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