FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2145500507> ?p ?o ?g. }

• W2145500507 endingPage "1928" @default.
• W2145500507 startingPage "1923" @default.
• W2145500507 abstract "In Citrobacter freundii and Enterobacter cloacae, synthesis of AmpC beta-lactamase is inducible by the addition of beta-lactams to the growth medium. Spontaneous mutants that constitutively overproduce the enzyme occur at a high frequency. When the C. freundii ampC beta-lactamase gene is cloned into Escherichia coli together with the regulatory gene ampR, beta-lactamase expression from the clone is inducible. Spontaneous cefotaxime-resistant mutants were selected from an E. coli strain carrying the cloned C. freundii ampC and ampR genes on a plasmid. Virtually all isolates had chromosomal mutations leading to semiconstitutive overproduction of beta-lactamase. The mutation ampD2 in one such mutant was caused by an IS1 insertion into the hitherto unknown ampD gene, located between nadC and aroP at minute 2.4 on the E. coli chromosome. The wild-type ampD allele cloned on a plasmid could fully trans-complement beta-lactamase-overproducing mutants of both E. coli and C. freundii, restoring the wild-type phenotype of highly inducible enzyme synthesis. This indicates that these E. coli and C. freundii mutants have their lesions in ampD. We hypothesize that induction of beta-lactamase synthesis is caused by blocking of the AmpD function by the beta-lactam inducer and that this leads directly or indirectly to an AmpR-mediated stimulation of ampC expression." @default.
• W2145500507 created "2016-06-24" @default.
• W2145500507 creator A5012528125 @default.
• W2145500507 creator A5055181418 @default.
• W2145500507 creator A5089043381 @default.
• W2145500507 date "1987-05-01" @default.
• W2145500507 modified "2023-09-26" @default.
• W2145500507 title "Inactivation of the ampD gene causes semiconstitutive overproduction of the inducible Citrobacter freundii beta-lactamase" @default.
• W2145500507 cites W1486946238 @default.
• W2145500507 cites W1495538657 @default.
• W2145500507 cites W1499291462 @default.
• W2145500507 cites W1521568789 @default.
• W2145500507 cites W1523866699 @default.
• W2145500507 cites W1552774497 @default.
• W2145500507 cites W1559157077 @default.
• W2145500507 cites W1560114212 @default.
• W2145500507 cites W1570998909 @default.
• W2145500507 cites W1617750329 @default.
• W2145500507 cites W1775749144 @default.
• W2145500507 cites W1943327251 @default.
• W2145500507 cites W1969456597 @default.
• W2145500507 cites W1975877183 @default.
• W2145500507 cites W1987634568 @default.
• W2145500507 cites W1996066959 @default.
• W2145500507 cites W1996960109 @default.
• W2145500507 cites W2013870760 @default.
• W2145500507 cites W2026986379 @default.
• W2145500507 cites W2031141462 @default.
• W2145500507 cites W2050077441 @default.
• W2145500507 cites W2050599642 @default.
• W2145500507 cites W2063679057 @default.
• W2145500507 cites W2079499351 @default.
• W2145500507 cites W2129043215 @default.
• W2145500507 cites W2129243815 @default.
• W2145500507 cites W2141653906 @default.
• W2145500507 cites W2151533084 @default.
• W2145500507 cites W2163279482 @default.
• W2145500507 cites W2312481240 @default.
• W2145500507 cites W2916217134 @default.
• W2145500507 cites W32699642 @default.
• W2145500507 cites W33062999 @default.
• W2145500507 doi "https://doi.org/10.1128/jb.169.5.1923-1928.1987" @default.
• W2145500507 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/212046" @default.
• W2145500507 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3032901" @default.
• W2145500507 hasPublicationYear "1987" @default.
• W2145500507 type Work @default.
• W2145500507 sameAs 2145500507 @default.
• W2145500507 citedByCount "147" @default.
• W2145500507 countsByYear W21455005072012 @default.
• W2145500507 countsByYear W21455005072013 @default.
• W2145500507 countsByYear W21455005072014 @default.
• W2145500507 countsByYear W21455005072015 @default.
• W2145500507 countsByYear W21455005072016 @default.
• W2145500507 countsByYear W21455005072017 @default.
• W2145500507 countsByYear W21455005072018 @default.
• W2145500507 countsByYear W21455005072019 @default.
• W2145500507 countsByYear W21455005072020 @default.
• W2145500507 countsByYear W21455005072021 @default.
• W2145500507 countsByYear W21455005072022 @default.
• W2145500507 countsByYear W21455005072023 @default.
• W2145500507 crossrefType "journal-article" @default.
• W2145500507 hasAuthorship W2145500507A5012528125 @default.
• W2145500507 hasAuthorship W2145500507A5055181418 @default.
• W2145500507 hasAuthorship W2145500507A5089043381 @default.
• W2145500507 hasBestOaLocation W21455005071 @default.
• W2145500507 hasConcept C104317684 @default.
• W2145500507 hasConcept C124420848 @default.
• W2145500507 hasConcept C143065580 @default.
• W2145500507 hasConcept C153911025 @default.
• W2145500507 hasConcept C165864922 @default.
• W2145500507 hasConcept C22744801 @default.
• W2145500507 hasConcept C2777402170 @default.
• W2145500507 hasConcept C2778709256 @default.
• W2145500507 hasConcept C2778910516 @default.
• W2145500507 hasConcept C33498276 @default.
• W2145500507 hasConcept C54355233 @default.
• W2145500507 hasConcept C547475151 @default.
• W2145500507 hasConcept C5527404 @default.
• W2145500507 hasConcept C86803240 @default.
• W2145500507 hasConcept C89423630 @default.
• W2145500507 hasConceptScore W2145500507C104317684 @default.
• W2145500507 hasConceptScore W2145500507C124420848 @default.
• W2145500507 hasConceptScore W2145500507C143065580 @default.
• W2145500507 hasConceptScore W2145500507C153911025 @default.
• W2145500507 hasConceptScore W2145500507C165864922 @default.
• W2145500507 hasConceptScore W2145500507C22744801 @default.
• W2145500507 hasConceptScore W2145500507C2777402170 @default.
• W2145500507 hasConceptScore W2145500507C2778709256 @default.
• W2145500507 hasConceptScore W2145500507C2778910516 @default.
• W2145500507 hasConceptScore W2145500507C33498276 @default.
• W2145500507 hasConceptScore W2145500507C54355233 @default.
• W2145500507 hasConceptScore W2145500507C547475151 @default.
• W2145500507 hasConceptScore W2145500507C5527404 @default.
• W2145500507 hasConceptScore W2145500507C86803240 @default.
• W2145500507 hasConceptScore W2145500507C89423630 @default.
• W2145500507 hasIssue "5" @default.
• W2145500507 hasLocation W21455005071 @default.
• W2145500507 hasLocation W21455005072 @default.

• next